SLC41A1,2 transport Mg2+ from extracellular region to cytosol

Stable Identifier
R-HSA-442661
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
MagT transporters mediate magnesium uptake into cells
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Magnesium (Mg2+) is an abundant cation that is important for many intracellular biochemical functions, especially as a cofactor for ATP. Intracellular Mg2+ concentrations must be finely regulated and recently, transporters for this cation have been elucidated. The human genes SLC41A1 and SLC41A2 encode magnesium transport proteins 1 and 2 respectively (MagT1 and MagT2). They both mediate the uptake of Mg2+ into cells (Goytain A and Quamme GA, 2005; Sahni J et al, 2007). A third human gene, SLC41A3, is also thought to encode a MagT protein but has not been characterized yet.

Literature References
PubMed ID Title Journal Year
15804357 Identification and characterization of a novel mammalian Mg2+ transporter with channel-like properties

Goytain, A, Quamme, GA

BMC Genomics 2005
16984228 SLC41A2 encodes a plasma-membrane Mg2+ transporter

Sahni, J, Nelson, B, Scharenberg, AM

Biochem J 2007
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
magnesium ion transmembrane transporter activity of SLC41A1,2 [plasma membrane]
Physical Entity
Activity
Orthologous Events
Cross References
Rhea
Authored
Reviewed
Created
Cite Us!