SLC41A1,2 transport Mg2+ from extracellular region to cytosol

Stable Identifier
R-HSA-442661
Type
Reaction [transition]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
MagT transporters mediate magnesium uptake into cells
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
SLC41A1,2 transport Mg2+ from extracellular region to cytosol
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Magnesium (Mg2+) is an abundant cation that is important for many intracellular biochemical functions, especially as a cofactor for ATP. Intracellular Mg2+ concentrations must be finely regulated and recently, transporters for this cation have been elucidated. The human genes SLC41A1 and SLC41A2 encode magnesium transport proteins 1 and 2 respectively (MagT1 and MagT2). They both mediate the uptake of Mg2+ into cells (Goytain A and Quamme GA, 2005; Sahni J et al, 2007). A third human gene, SLC41A3, is also thought to encode a MagT protein but has not been characterized yet.
Literature References
PubMed ID Title Journal Year
16984228 SLC41A2 encodes a plasma-membrane Mg2+ transporter

Sahni, J, Nelson, B, Scharenberg, AM

Biochem J 2007
15804357 Identification and characterization of a novel mammalian Mg2+ transporter with channel-like properties

Goytain, A, Quamme, GA

BMC Genomics 2005
Participants
Input
Output
Participates
as an event of
Catalyst Activity

magnesium ion transmembrane transporter activity of SLC41A1,2 [plasma membrane]

Physical Entity
SLC41A1,2 [plasma membrane] (Homo sapiens)
Activity
magnesium ion transmembrane transporter activity (GO:0015095)
Orthologous Events
SLC41A1,2 transport Mg2+ from extracellular region to cytosol (Bos taurus)
SLC41A1,2 transport Mg2+ from extracellular region to cytosol (Caenorhabditis elegans)
SLC41A1,2 transport Mg2+ from extracellular region to cytosol (Canis familiaris)
SLC41A1,2 transport Mg2+ from extracellular region to cytosol (Danio rerio)
SLC41A1,2 transport Mg2+ from extracellular region to cytosol (Drosophila melanogaster)
SLC41A1,2 transport Mg2+ from extracellular region to cytosol (Gallus gallus)
SLC41A1,2 transport Mg2+ from extracellular region to cytosol (Mus musculus)
SLC41A1,2 transport Mg2+ from extracellular region to cytosol (Rattus norvegicus)
SLC41A1,2 transport Mg2+ from extracellular region to cytosol (Sus scrofa)
SLC41A1,2 transport Mg2+ from extracellular region to cytosol (Xenopus tropicalis)
Cross References
RHEA
Authored
Jassal, B  (2009-09-29)
Reviewed
He, L  (2009-11-12)
Created
Jassal, B  (2009-09-29)
Cite Us!