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Mg2+ [extracellular region]
Stable Identifier
R-ALL-114632
Type
Chemical Compound [SimpleEntity]
Compartment
extracellular region
Synonyms
Magnesium, magnesium(2+), Mg++
Locations in the PathwayBrowser
for Species:
Homo sapiens
Bos taurus
Caenorhabditis elegans
Canis familiaris
Danio rerio
Dictyostelium discoideum
Drosophila melanogaster
Gallus gallus
Mus musculus
Plasmodium falciparum
Rattus norvegicus
Saccharomyces cerevisiae
Schizosaccharomyces pombe
Sus scrofa
Xenopus tropicalis
Expand all
Extracellular matrix organization (Bos taurus)
Integrin cell surface interactions (Bos taurus)
Collagen type I binds integrin alpha11beta1 (Bos taurus)
Mg2+ [extracellular region]
Collagen type I:Mg2+:Integrin alpha 11 beta 1 [plasma membrane] (Bos taurus)
Mg2+ [extracellular region]
Collagen type II binds integrin alpha10beta1 (Bos taurus)
Mg2+ [extracellular region]
Integrin alpha10beta1:Collagen type II fibril:Mg2+ [plasma membrane] (Bos taurus)
Mg2+ [extracellular region]
Hemostasis (Bos taurus)
Platelet activation, signaling and aggregation (Bos taurus)
Platelet Aggregation (Plug Formation) (Bos taurus)
Integrin signaling (Bos taurus)
Autophosphorylation of PTK2 at Y397 (Bos taurus)
Talin:RIAM complex: ECM ligands:Integrin alphaIIb beta3:Active (p-Y419)- SRC:PTK2 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Talin:RIAM complex:ECM ligands: alphaIIb beta3:Active p-Y419-SRC:pY397-PTK2 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Autophosphorylation of SRC (Bos taurus)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:SRC) [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Clustering of Integrin alphaIIb beta3 complexes (Bos taurus)
Focal complex [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Dephosphorylation of inactive SRC by PTPB1 (Bos taurus)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:Inactive (p-Y530)-SRC) [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:SRC) [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
GRB2:SOS provides linkage to MAPK signaling for Integrins (Bos taurus)
Interaction of SOS with GRB2 bound to FADK1 (Bos taurus)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
GRB2:SOS:p-PTK2:Focal adhesion [plasma membrane] (Bos taurus)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Recruitment of GRB2 to p-PTK2 (Bos taurus)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Interaction of integrin alphaIIb beta3 with Fibrinogen (Bos taurus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Focal complex [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Phosphorylation of pPTK2 by SRC (Bos taurus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Talin:RIAM complex:ECM ligands: alphaIIb beta3:Active p-Y419-SRC:pY397-PTK2 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Release of CSK from SRC (Bos taurus)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:Inactive (p-Y530)-SRC) [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
SYK activation by SRC (Bos taurus)
Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Talin:RIAM:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC):p(Y)-SYK [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
SYK binds to integrin alphaIIb beta3 (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Translocation of PTK2 to Focal complexes (Bos taurus)
Talin:RIAM complex: ECM ligands:Integrin alphaIIb beta3:Active (p-Y419)- SRC:PTK2 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
p130Cas linkage to MAPK signaling for integrins (Bos taurus)
Crk binding to p130cas (Bos taurus)
CRK:p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Bos taurus)
p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Phosphorylation of BCAR1 by SRC-PTK2 complex (Bos taurus)
BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Recruitment of BCAR1 to PTK2 complex (Bos taurus)
BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Response to elevated platelet cytosolic Ca2+ (Bos taurus)
Platelet degranulation (Bos taurus)
Exocytosis of platelet dense granule content (Bos taurus)
Platelet dense granule content [extracellular region] (Bos taurus)
Mg2+ [extracellular region]
Platelet homeostasis (Bos taurus)
Platelet calcium homeostasis (Bos taurus)
Elevation of cytosolic Ca2+ levels (Bos taurus)
Cation influx mediated by TRPC3/6/7 (Bos taurus)
Cations [extracellular region]
Mg2+ [extracellular region]
Metabolism (Bos taurus)
Metabolism of nucleotides (Bos taurus)
Nucleotide catabolism (Bos taurus)
Phosphate bond hydrolysis by NTPDase proteins (Bos taurus)
NTPDase1 hydrolyzes nucleoside diphosphates (Bos taurus)
NTPDase1:Ca2+,Mg2+ [plasma membrane] (Bos taurus)
Ca2+,Mg2+ [extracellular region]
Mg2+ [extracellular region]
NTPDase1 hydrolyzes nucleoside triphosphates (Bos taurus)
NTPDase1:Ca2+,Mg2+ [plasma membrane] (Bos taurus)
Ca2+,Mg2+ [extracellular region]
Mg2+ [extracellular region]
NTPDase2 hydrolyzes nucleoside triphosphates (Bos taurus)
NTPDase2:Ca2+,Mg2+ [plasma membrane] (Bos taurus)
Ca2+,Mg2+ [extracellular region]
Mg2+ [extracellular region]
NTPDase3 hydrolyzes nucleoside diphosphates (Bos taurus)
NTPDase3:Ca2+,Mg2+ [plasma membrane] (Bos taurus)
Ca2+,Mg2+ [extracellular region]
Mg2+ [extracellular region]
NTPDase3 hydrolyzes nucleoside triphosphates (Bos taurus)
NTPDase3:Ca2+,Mg2+ [plasma membrane] (Bos taurus)
Ca2+,Mg2+ [extracellular region]
Mg2+ [extracellular region]
NTPDase5 hydrolyzes nucleoside diphosphates (Bos taurus)
NPTDase5:Ca2+,Mg2+ [extracellular region] (Bos taurus)
Ca2+,Mg2+ [extracellular region]
Mg2+ [extracellular region]
NTPDase6 hydrolyzes nucleoside diphosphates (Bos taurus)
NTPDase6:Ca2+,Mg2+ [extracellular region] (Bos taurus)
Ca2+,Mg2+ [extracellular region]
Mg2+ [extracellular region]
NTPDase8 hydrolyzes nucleoside diphosphates (Bos taurus)
NTPDase8:Ca2+,Mg2+ [plasma membrane] (Bos taurus)
Ca2+,Mg2+ [extracellular region]
Mg2+ [extracellular region]
NTPDase8 hydrolyzes nucleoside triphosphates (Bos taurus)
NTPDase8:Ca2+,Mg2+ [plasma membrane] (Bos taurus)
Ca2+,Mg2+ [extracellular region]
Mg2+ [extracellular region]
Signal Transduction (Bos taurus)
Integrin signaling (Bos taurus)
Autophosphorylation of PTK2 at Y397 (Bos taurus)
Talin:RIAM complex: ECM ligands:Integrin alphaIIb beta3:Active (p-Y419)- SRC:PTK2 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Talin:RIAM complex:ECM ligands: alphaIIb beta3:Active p-Y419-SRC:pY397-PTK2 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Autophosphorylation of SRC (Bos taurus)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:SRC) [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Clustering of Integrin alphaIIb beta3 complexes (Bos taurus)
Focal complex [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Dephosphorylation of inactive SRC by PTPB1 (Bos taurus)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:Inactive (p-Y530)-SRC) [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:SRC) [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
GRB2:SOS provides linkage to MAPK signaling for Integrins (Bos taurus)
Interaction of SOS with GRB2 bound to FADK1 (Bos taurus)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
GRB2:SOS:p-PTK2:Focal adhesion [plasma membrane] (Bos taurus)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Recruitment of GRB2 to p-PTK2 (Bos taurus)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Interaction of integrin alphaIIb beta3 with Fibrinogen (Bos taurus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Focal complex [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Phosphorylation of pPTK2 by SRC (Bos taurus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Talin:RIAM complex:ECM ligands: alphaIIb beta3:Active p-Y419-SRC:pY397-PTK2 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Release of CSK from SRC (Bos taurus)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:Inactive (p-Y530)-SRC) [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
SYK activation by SRC (Bos taurus)
Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Talin:RIAM:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC):p(Y)-SYK [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
SYK binds to integrin alphaIIb beta3 (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Translocation of PTK2 to Focal complexes (Bos taurus)
Talin:RIAM complex: ECM ligands:Integrin alphaIIb beta3:Active (p-Y419)- SRC:PTK2 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
p130Cas linkage to MAPK signaling for integrins (Bos taurus)
Crk binding to p130cas (Bos taurus)
CRK:p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Bos taurus)
p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Phosphorylation of BCAR1 by SRC-PTK2 complex (Bos taurus)
BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Recruitment of BCAR1 to PTK2 complex (Bos taurus)
BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
MAPK family signaling cascades (Bos taurus)
MAPK1/MAPK3 signaling (Bos taurus)
RAF/MAP kinase cascade (Bos taurus)
MAP2K and MAPK activation (Bos taurus)
Dissociation of RAS:RAF complex (Bos taurus)
RAF/MAPK scaffolds [cytosol] (Bos taurus)
Focal Adhesion/Focal contacts [plasma membrane] (Bos taurus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Bos taurus)
Focal complex [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Bos taurus)
RAF/MAPK scaffolds [cytosol] (Bos taurus)
Focal Adhesion/Focal contacts [plasma membrane] (Bos taurus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Bos taurus)
Focal complex [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Dual mechanism MAP2K inhibitors bind MAP2Ks (Bos taurus)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Bos taurus)
RAF/MAPK scaffolds [cytosol] (Bos taurus)
Focal Adhesion/Focal contacts [plasma membrane] (Bos taurus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Bos taurus)
Focal complex [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Bos taurus)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Bos taurus)
RAF/MAPK scaffolds [cytosol] (Bos taurus)
Focal Adhesion/Focal contacts [plasma membrane] (Bos taurus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Bos taurus)
Focal complex [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Dual mechanism MAPK inhibitors bind MAPKs (Bos taurus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Bos taurus)
RAF/MAPK scaffolds [cytosol] (Bos taurus)
Focal Adhesion/Focal contacts [plasma membrane] (Bos taurus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Bos taurus)
Focal complex [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors [plasma membrane] (Bos taurus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Bos taurus)
RAF/MAPK scaffolds [cytosol] (Bos taurus)
Focal Adhesion/Focal contacts [plasma membrane] (Bos taurus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Bos taurus)
Focal complex [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
MAP2Ks and MAPKs bind to the activated RAF complex (Bos taurus)
RAF/MAPK scaffolds [cytosol] (Bos taurus)
Focal Adhesion/Focal contacts [plasma membrane] (Bos taurus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Bos taurus)
Focal complex [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Bos taurus)
RAF/MAPK scaffolds [cytosol] (Bos taurus)
Focal Adhesion/Focal contacts [plasma membrane] (Bos taurus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Bos taurus)
Focal complex [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
MAP2Ks phosphorylate MAPKs (Bos taurus)
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Bos taurus)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Bos taurus)
RAF/MAPK scaffolds [cytosol] (Bos taurus)
Focal Adhesion/Focal contacts [plasma membrane] (Bos taurus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Bos taurus)
Focal complex [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Bos taurus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Bos taurus)
RAF/MAPK scaffolds [cytosol] (Bos taurus)
Focal Adhesion/Focal contacts [plasma membrane] (Bos taurus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Bos taurus)
Focal complex [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Bos taurus)
RAF/MAPK scaffolds [cytosol] (Bos taurus)
Focal Adhesion/Focal contacts [plasma membrane] (Bos taurus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Bos taurus)
Focal complex [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors [plasma membrane] (Bos taurus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Bos taurus)
RAF/MAPK scaffolds [cytosol] (Bos taurus)
Focal Adhesion/Focal contacts [plasma membrane] (Bos taurus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Bos taurus)
Focal complex [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Bos taurus)
RAF/MAPK scaffolds [cytosol] (Bos taurus)
Focal Adhesion/Focal contacts [plasma membrane] (Bos taurus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Bos taurus)
Focal complex [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
RAF phosphorylates MAP2K dimer (Bos taurus)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Bos taurus)
RAF/MAPK scaffolds [cytosol] (Bos taurus)
Focal Adhesion/Focal contacts [plasma membrane] (Bos taurus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Bos taurus)
Focal complex [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Bos taurus)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Bos taurus)
RAF/MAPK scaffolds [cytosol] (Bos taurus)
Focal Adhesion/Focal contacts [plasma membrane] (Bos taurus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Bos taurus)
Focal complex [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Bos taurus)
RAF/MAPK scaffolds [cytosol] (Bos taurus)
Focal Adhesion/Focal contacts [plasma membrane] (Bos taurus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Bos taurus)
Focal complex [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks (Bos taurus)
activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Bos taurus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Bos taurus)
RAF/MAPK scaffolds [cytosol] (Bos taurus)
Focal Adhesion/Focal contacts [plasma membrane] (Bos taurus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Bos taurus)
Focal complex [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Bos taurus)
RAF/MAPK scaffolds [cytosol] (Bos taurus)
Focal Adhesion/Focal contacts [plasma membrane] (Bos taurus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Bos taurus)
Focal complex [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Single mechanism MAPK inhibitors bind phosphorylated MAPK (Bos taurus)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Bos taurus)
RAF/MAPK scaffolds [cytosol] (Bos taurus)
Focal Adhesion/Focal contacts [plasma membrane] (Bos taurus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Bos taurus)
Focal complex [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK:single mechanism MAPK inhibitors [plasma membrane] (Bos taurus)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Bos taurus)
RAF/MAPK scaffolds [cytosol] (Bos taurus)
Focal Adhesion/Focal contacts [plasma membrane] (Bos taurus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Bos taurus)
Focal complex [plasma membrane] (Bos taurus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Transport of small molecules (Bos taurus)
Miscellaneous transport and binding events (Bos taurus)
MAGT1 transports Mg2+ from extracellular region to cytosol (Bos taurus)
Mg2+ [extracellular region]
NIPAs transport Mg2+ from extracellular region to cytosol (Bos taurus)
Mg2+ [extracellular region]
TUSC3 transports Mg2+ from extracellular region to cytosol (Bos taurus)
Mg2+ [extracellular region]
SLC-mediated transmembrane transport (Bos taurus)
Transport of bile salts and organic acids, metal ions and amine compounds (Bos taurus)
Metal ion SLC transporters (Bos taurus)
SLC41A1,2 transport Mg2+ from extracellular region to cytosol (Bos taurus)
Mg2+ [extracellular region]
Extracellular matrix organization (Caenorhabditis elegans)
Integrin cell surface interactions (Caenorhabditis elegans)
Collagen type I binds integrin alpha11beta1 (Caenorhabditis elegans)
Mg2+ [extracellular region]
Collagen type I:Mg2+:Integrin alpha 11 beta 1 [plasma membrane] (Caenorhabditis elegans)
Mg2+ [extracellular region]
Collagen type II binds integrin alpha10beta1 (Caenorhabditis elegans)
Mg2+ [extracellular region]
Integrin alpha10beta1:Collagen type II fibril:Mg2+ [plasma membrane] (Caenorhabditis elegans)
Mg2+ [extracellular region]
Hemostasis (Caenorhabditis elegans)
Platelet activation, signaling and aggregation (Caenorhabditis elegans)
Platelet Aggregation (Plug Formation) (Caenorhabditis elegans)
Integrin signaling (Caenorhabditis elegans)
Autophosphorylation of PTK2 at Y397 (Caenorhabditis elegans)
Talin:RIAM complex: ECM ligands:Integrin alphaIIb beta3:Active (p-Y419)- SRC:PTK2 [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Talin:RIAM complex:ECM ligands: alphaIIb beta3:Active p-Y419-SRC:pY397-PTK2 [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Autophosphorylation of SRC (Caenorhabditis elegans)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:SRC) [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Clustering of Integrin alphaIIb beta3 complexes (Caenorhabditis elegans)
Focal complex [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
GRB2:SOS provides linkage to MAPK signaling for Integrins (Caenorhabditis elegans)
Interaction of SOS with GRB2 bound to FADK1 (Caenorhabditis elegans)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
GRB2:SOS:p-PTK2:Focal adhesion [plasma membrane] (Caenorhabditis elegans)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Recruitment of GRB2 to p-PTK2 (Caenorhabditis elegans)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Interaction of integrin alphaIIb beta3 with Fibrinogen (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Focal complex [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Phosphorylation of pPTK2 by SRC (Caenorhabditis elegans)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Talin:RIAM complex:ECM ligands: alphaIIb beta3:Active p-Y419-SRC:pY397-PTK2 [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Release of CSK from SRC (Caenorhabditis elegans)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:Inactive (p-Y530)-SRC) [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
SYK activation by SRC (Caenorhabditis elegans)
Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Talin:RIAM:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC):p(Y)-SYK [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
SYK binds to integrin alphaIIb beta3 (Caenorhabditis elegans)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Translocation of PTK2 to Focal complexes (Caenorhabditis elegans)
Talin:RIAM complex: ECM ligands:Integrin alphaIIb beta3:Active (p-Y419)- SRC:PTK2 [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Response to elevated platelet cytosolic Ca2+ (Caenorhabditis elegans)
Platelet degranulation (Caenorhabditis elegans)
Exocytosis of platelet dense granule content (Caenorhabditis elegans)
Platelet dense granule content [extracellular region] (Caenorhabditis elegans)
Mg2+ [extracellular region]
Platelet homeostasis (Caenorhabditis elegans)
Platelet calcium homeostasis (Caenorhabditis elegans)
Elevation of cytosolic Ca2+ levels (Caenorhabditis elegans)
Cation influx mediated by TRPC3/6/7 (Caenorhabditis elegans)
Cations [extracellular region]
Mg2+ [extracellular region]
Metabolism (Caenorhabditis elegans)
Metabolism of nucleotides (Caenorhabditis elegans)
Nucleotide catabolism (Caenorhabditis elegans)
Phosphate bond hydrolysis by NTPDase proteins (Caenorhabditis elegans)
NTPDase5 hydrolyzes nucleoside diphosphates (Caenorhabditis elegans)
NPTDase5:Ca2+,Mg2+ [extracellular region] (Caenorhabditis elegans)
Ca2+,Mg2+ [extracellular region]
Mg2+ [extracellular region]
NTPDase6 hydrolyzes nucleoside diphosphates (Caenorhabditis elegans)
NTPDase6:Ca2+,Mg2+ [extracellular region] (Caenorhabditis elegans)
Ca2+,Mg2+ [extracellular region]
Mg2+ [extracellular region]
Signal Transduction (Caenorhabditis elegans)
Integrin signaling (Caenorhabditis elegans)
Autophosphorylation of PTK2 at Y397 (Caenorhabditis elegans)
Talin:RIAM complex: ECM ligands:Integrin alphaIIb beta3:Active (p-Y419)- SRC:PTK2 [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Talin:RIAM complex:ECM ligands: alphaIIb beta3:Active p-Y419-SRC:pY397-PTK2 [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Autophosphorylation of SRC (Caenorhabditis elegans)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:SRC) [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Clustering of Integrin alphaIIb beta3 complexes (Caenorhabditis elegans)
Focal complex [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
GRB2:SOS provides linkage to MAPK signaling for Integrins (Caenorhabditis elegans)
Interaction of SOS with GRB2 bound to FADK1 (Caenorhabditis elegans)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
GRB2:SOS:p-PTK2:Focal adhesion [plasma membrane] (Caenorhabditis elegans)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Recruitment of GRB2 to p-PTK2 (Caenorhabditis elegans)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Interaction of integrin alphaIIb beta3 with Fibrinogen (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Focal complex [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Phosphorylation of pPTK2 by SRC (Caenorhabditis elegans)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Talin:RIAM complex:ECM ligands: alphaIIb beta3:Active p-Y419-SRC:pY397-PTK2 [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Release of CSK from SRC (Caenorhabditis elegans)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:Inactive (p-Y530)-SRC) [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
SYK activation by SRC (Caenorhabditis elegans)
Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Talin:RIAM:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC):p(Y)-SYK [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
SYK binds to integrin alphaIIb beta3 (Caenorhabditis elegans)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Translocation of PTK2 to Focal complexes (Caenorhabditis elegans)
Talin:RIAM complex: ECM ligands:Integrin alphaIIb beta3:Active (p-Y419)- SRC:PTK2 [plasma membrane] (Caenorhabditis elegans)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
MAPK family signaling cascades (Caenorhabditis elegans)
MAPK1/MAPK3 signaling (Caenorhabditis elegans)
RAF/MAP kinase cascade (Caenorhabditis elegans)
MAP2K and MAPK activation (Caenorhabditis elegans)
Dissociation of RAS:RAF complex (Caenorhabditis elegans)
RAF/MAPK scaffolds [cytosol] (Caenorhabditis elegans)
Focal Adhesion/Focal contacts [plasma membrane] (Caenorhabditis elegans)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Caenorhabditis elegans)
Focal complex [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Caenorhabditis elegans)
RAF/MAPK scaffolds [cytosol] (Caenorhabditis elegans)
Focal Adhesion/Focal contacts [plasma membrane] (Caenorhabditis elegans)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Caenorhabditis elegans)
Focal complex [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Dual mechanism MAP2K inhibitors bind MAP2Ks (Caenorhabditis elegans)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Caenorhabditis elegans)
RAF/MAPK scaffolds [cytosol] (Caenorhabditis elegans)
Focal Adhesion/Focal contacts [plasma membrane] (Caenorhabditis elegans)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Caenorhabditis elegans)
Focal complex [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Caenorhabditis elegans)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Caenorhabditis elegans)
RAF/MAPK scaffolds [cytosol] (Caenorhabditis elegans)
Focal Adhesion/Focal contacts [plasma membrane] (Caenorhabditis elegans)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Caenorhabditis elegans)
Focal complex [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Dual mechanism MAPK inhibitors bind MAPKs (Caenorhabditis elegans)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Caenorhabditis elegans)
RAF/MAPK scaffolds [cytosol] (Caenorhabditis elegans)
Focal Adhesion/Focal contacts [plasma membrane] (Caenorhabditis elegans)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Caenorhabditis elegans)
Focal complex [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors [plasma membrane] (Caenorhabditis elegans)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Caenorhabditis elegans)
RAF/MAPK scaffolds [cytosol] (Caenorhabditis elegans)
Focal Adhesion/Focal contacts [plasma membrane] (Caenorhabditis elegans)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Caenorhabditis elegans)
Focal complex [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
MAP2Ks and MAPKs bind to the activated RAF complex (Caenorhabditis elegans)
RAF/MAPK scaffolds [cytosol] (Caenorhabditis elegans)
Focal Adhesion/Focal contacts [plasma membrane] (Caenorhabditis elegans)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Caenorhabditis elegans)
Focal complex [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Caenorhabditis elegans)
RAF/MAPK scaffolds [cytosol] (Caenorhabditis elegans)
Focal Adhesion/Focal contacts [plasma membrane] (Caenorhabditis elegans)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Caenorhabditis elegans)
Focal complex [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
MAP2Ks phosphorylate MAPKs (Caenorhabditis elegans)
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Caenorhabditis elegans)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Caenorhabditis elegans)
RAF/MAPK scaffolds [cytosol] (Caenorhabditis elegans)
Focal Adhesion/Focal contacts [plasma membrane] (Caenorhabditis elegans)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Caenorhabditis elegans)
Focal complex [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Caenorhabditis elegans)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Caenorhabditis elegans)
RAF/MAPK scaffolds [cytosol] (Caenorhabditis elegans)
Focal Adhesion/Focal contacts [plasma membrane] (Caenorhabditis elegans)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Caenorhabditis elegans)
Focal complex [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Caenorhabditis elegans)
RAF/MAPK scaffolds [cytosol] (Caenorhabditis elegans)
Focal Adhesion/Focal contacts [plasma membrane] (Caenorhabditis elegans)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Caenorhabditis elegans)
Focal complex [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors [plasma membrane] (Caenorhabditis elegans)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Caenorhabditis elegans)
RAF/MAPK scaffolds [cytosol] (Caenorhabditis elegans)
Focal Adhesion/Focal contacts [plasma membrane] (Caenorhabditis elegans)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Caenorhabditis elegans)
Focal complex [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Caenorhabditis elegans)
RAF/MAPK scaffolds [cytosol] (Caenorhabditis elegans)
Focal Adhesion/Focal contacts [plasma membrane] (Caenorhabditis elegans)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Caenorhabditis elegans)
Focal complex [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
RAF phosphorylates MAP2K dimer (Caenorhabditis elegans)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Caenorhabditis elegans)
RAF/MAPK scaffolds [cytosol] (Caenorhabditis elegans)
Focal Adhesion/Focal contacts [plasma membrane] (Caenorhabditis elegans)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Caenorhabditis elegans)
Focal complex [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Caenorhabditis elegans)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Caenorhabditis elegans)
RAF/MAPK scaffolds [cytosol] (Caenorhabditis elegans)
Focal Adhesion/Focal contacts [plasma membrane] (Caenorhabditis elegans)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Caenorhabditis elegans)
Focal complex [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Caenorhabditis elegans)
RAF/MAPK scaffolds [cytosol] (Caenorhabditis elegans)
Focal Adhesion/Focal contacts [plasma membrane] (Caenorhabditis elegans)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Caenorhabditis elegans)
Focal complex [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks (Caenorhabditis elegans)
activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Caenorhabditis elegans)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Caenorhabditis elegans)
RAF/MAPK scaffolds [cytosol] (Caenorhabditis elegans)
Focal Adhesion/Focal contacts [plasma membrane] (Caenorhabditis elegans)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Caenorhabditis elegans)
Focal complex [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Caenorhabditis elegans)
RAF/MAPK scaffolds [cytosol] (Caenorhabditis elegans)
Focal Adhesion/Focal contacts [plasma membrane] (Caenorhabditis elegans)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Caenorhabditis elegans)
Focal complex [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Single mechanism MAPK inhibitors bind phosphorylated MAPK (Caenorhabditis elegans)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Caenorhabditis elegans)
RAF/MAPK scaffolds [cytosol] (Caenorhabditis elegans)
Focal Adhesion/Focal contacts [plasma membrane] (Caenorhabditis elegans)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Caenorhabditis elegans)
Focal complex [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK:single mechanism MAPK inhibitors [plasma membrane] (Caenorhabditis elegans)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Caenorhabditis elegans)
RAF/MAPK scaffolds [cytosol] (Caenorhabditis elegans)
Focal Adhesion/Focal contacts [plasma membrane] (Caenorhabditis elegans)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Caenorhabditis elegans)
Focal complex [plasma membrane] (Caenorhabditis elegans)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Transport of small molecules (Caenorhabditis elegans)
Miscellaneous transport and binding events (Caenorhabditis elegans)
MAGT1 transports Mg2+ from extracellular region to cytosol (Caenorhabditis elegans)
Mg2+ [extracellular region]
NIPAs transport Mg2+ from extracellular region to cytosol (Caenorhabditis elegans)
Mg2+ [extracellular region]
TUSC3 transports Mg2+ from extracellular region to cytosol (Caenorhabditis elegans)
Mg2+ [extracellular region]
SLC-mediated transmembrane transport (Caenorhabditis elegans)
Transport of bile salts and organic acids, metal ions and amine compounds (Caenorhabditis elegans)
Metal ion SLC transporters (Caenorhabditis elegans)
SLC41A1,2 transport Mg2+ from extracellular region to cytosol (Caenorhabditis elegans)
Mg2+ [extracellular region]
Extracellular matrix organization (Canis familiaris)
Integrin cell surface interactions (Canis familiaris)
Collagen type I binds integrin alpha11beta1 (Canis familiaris)
Mg2+ [extracellular region]
Collagen type I:Mg2+:Integrin alpha 11 beta 1 [plasma membrane] (Canis familiaris)
Mg2+ [extracellular region]
Collagen type II binds integrin alpha10beta1 (Canis familiaris)
Mg2+ [extracellular region]
Integrin alpha10beta1:Collagen type II fibril:Mg2+ [plasma membrane] (Canis familiaris)
Mg2+ [extracellular region]
Hemostasis (Canis familiaris)
Platelet activation, signaling and aggregation (Canis familiaris)
Platelet Aggregation (Plug Formation) (Canis familiaris)
Integrin signaling (Canis familiaris)
Autophosphorylation of PTK2 at Y397 (Canis familiaris)
Talin:RIAM complex: ECM ligands:Integrin alphaIIb beta3:Active (p-Y419)- SRC:PTK2 [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Talin:RIAM complex:ECM ligands: alphaIIb beta3:Active p-Y419-SRC:pY397-PTK2 [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Autophosphorylation of SRC (Canis familiaris)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:SRC) [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Clustering of Integrin alphaIIb beta3 complexes (Canis familiaris)
Focal complex [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Dephosphorylation of inactive SRC by PTPB1 (Canis familiaris)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:Inactive (p-Y530)-SRC) [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:SRC) [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
GRB2:SOS provides linkage to MAPK signaling for Integrins (Canis familiaris)
Interaction of SOS with GRB2 bound to FADK1 (Canis familiaris)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
GRB2:SOS:p-PTK2:Focal adhesion [plasma membrane] (Canis familiaris)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Recruitment of GRB2 to p-PTK2 (Canis familiaris)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Interaction of integrin alphaIIb beta3 with Fibrinogen (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Focal complex [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Phosphorylation of pPTK2 by SRC (Canis familiaris)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Talin:RIAM complex:ECM ligands: alphaIIb beta3:Active p-Y419-SRC:pY397-PTK2 [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Release of CSK from SRC (Canis familiaris)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:Inactive (p-Y530)-SRC) [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
SYK activation by SRC (Canis familiaris)
Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Talin:RIAM:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC):p(Y)-SYK [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
SYK binds to integrin alphaIIb beta3 (Canis familiaris)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Translocation of PTK2 to Focal complexes (Canis familiaris)
Talin:RIAM complex: ECM ligands:Integrin alphaIIb beta3:Active (p-Y419)- SRC:PTK2 [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
p130Cas linkage to MAPK signaling for integrins (Canis familiaris)
Crk binding to p130cas (Canis familiaris)
CRK:p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Canis familiaris)
p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Phosphorylation of BCAR1 by SRC-PTK2 complex (Canis familiaris)
BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Recruitment of BCAR1 to PTK2 complex (Canis familiaris)
BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Response to elevated platelet cytosolic Ca2+ (Canis familiaris)
Platelet degranulation (Canis familiaris)
Exocytosis of platelet dense granule content (Canis familiaris)
Platelet dense granule content [extracellular region] (Canis familiaris)
Mg2+ [extracellular region]
Platelet homeostasis (Canis familiaris)
Platelet calcium homeostasis (Canis familiaris)
Elevation of cytosolic Ca2+ levels (Canis familiaris)
Cation influx mediated by TRPC3/6/7 (Canis familiaris)
Cations [extracellular region]
Mg2+ [extracellular region]
Metabolism (Canis familiaris)
Metabolism of nucleotides (Canis familiaris)
Nucleotide catabolism (Canis familiaris)
Phosphate bond hydrolysis by NTPDase proteins (Canis familiaris)
NTPDase1 hydrolyzes nucleoside diphosphates (Canis familiaris)
NTPDase1:Ca2+,Mg2+ [plasma membrane] (Canis familiaris)
Ca2+,Mg2+ [extracellular region]
Mg2+ [extracellular region]
NTPDase1 hydrolyzes nucleoside triphosphates (Canis familiaris)
NTPDase1:Ca2+,Mg2+ [plasma membrane] (Canis familiaris)
Ca2+,Mg2+ [extracellular region]
Mg2+ [extracellular region]
NTPDase2 hydrolyzes nucleoside triphosphates (Canis familiaris)
NTPDase2:Ca2+,Mg2+ [plasma membrane] (Canis familiaris)
Ca2+,Mg2+ [extracellular region]
Mg2+ [extracellular region]
NTPDase3 hydrolyzes nucleoside diphosphates (Canis familiaris)
NTPDase3:Ca2+,Mg2+ [plasma membrane] (Canis familiaris)
Ca2+,Mg2+ [extracellular region]
Mg2+ [extracellular region]
NTPDase3 hydrolyzes nucleoside triphosphates (Canis familiaris)
NTPDase3:Ca2+,Mg2+ [plasma membrane] (Canis familiaris)
Ca2+,Mg2+ [extracellular region]
Mg2+ [extracellular region]
NTPDase5 hydrolyzes nucleoside diphosphates (Canis familiaris)
NPTDase5:Ca2+,Mg2+ [extracellular region] (Canis familiaris)
Ca2+,Mg2+ [extracellular region]
Mg2+ [extracellular region]
NTPDase6 hydrolyzes nucleoside diphosphates (Canis familiaris)
NTPDase6:Ca2+,Mg2+ [extracellular region] (Canis familiaris)
Ca2+,Mg2+ [extracellular region]
Mg2+ [extracellular region]
NTPDase8 hydrolyzes nucleoside diphosphates (Canis familiaris)
NTPDase8:Ca2+,Mg2+ [plasma membrane] (Canis familiaris)
Ca2+,Mg2+ [extracellular region]
Mg2+ [extracellular region]
NTPDase8 hydrolyzes nucleoside triphosphates (Canis familiaris)
NTPDase8:Ca2+,Mg2+ [plasma membrane] (Canis familiaris)
Ca2+,Mg2+ [extracellular region]
Mg2+ [extracellular region]
Signal Transduction (Canis familiaris)
Integrin signaling (Canis familiaris)
Autophosphorylation of PTK2 at Y397 (Canis familiaris)
Talin:RIAM complex: ECM ligands:Integrin alphaIIb beta3:Active (p-Y419)- SRC:PTK2 [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Talin:RIAM complex:ECM ligands: alphaIIb beta3:Active p-Y419-SRC:pY397-PTK2 [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Autophosphorylation of SRC (Canis familiaris)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:SRC) [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Clustering of Integrin alphaIIb beta3 complexes (Canis familiaris)
Focal complex [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Dephosphorylation of inactive SRC by PTPB1 (Canis familiaris)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:Inactive (p-Y530)-SRC) [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:SRC) [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
GRB2:SOS provides linkage to MAPK signaling for Integrins (Canis familiaris)
Interaction of SOS with GRB2 bound to FADK1 (Canis familiaris)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
GRB2:SOS:p-PTK2:Focal adhesion [plasma membrane] (Canis familiaris)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Recruitment of GRB2 to p-PTK2 (Canis familiaris)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Interaction of integrin alphaIIb beta3 with Fibrinogen (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Focal complex [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Phosphorylation of pPTK2 by SRC (Canis familiaris)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Talin:RIAM complex:ECM ligands: alphaIIb beta3:Active p-Y419-SRC:pY397-PTK2 [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Release of CSK from SRC (Canis familiaris)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:Inactive (p-Y530)-SRC) [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
SYK activation by SRC (Canis familiaris)
Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Talin:RIAM:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC):p(Y)-SYK [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
SYK binds to integrin alphaIIb beta3 (Canis familiaris)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Translocation of PTK2 to Focal complexes (Canis familiaris)
Talin:RIAM complex: ECM ligands:Integrin alphaIIb beta3:Active (p-Y419)- SRC:PTK2 [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
p130Cas linkage to MAPK signaling for integrins (Canis familiaris)
Crk binding to p130cas (Canis familiaris)
CRK:p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Canis familiaris)
p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Phosphorylation of BCAR1 by SRC-PTK2 complex (Canis familiaris)
BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Recruitment of BCAR1 to PTK2 complex (Canis familiaris)
BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Canis familiaris)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
MAPK family signaling cascades (Canis familiaris)
MAPK1/MAPK3 signaling (Canis familiaris)
RAF/MAP kinase cascade (Canis familiaris)
MAP2K and MAPK activation (Canis familiaris)
Dissociation of RAS:RAF complex (Canis familiaris)
RAF/MAPK scaffolds [cytosol] (Canis familiaris)
Focal Adhesion/Focal contacts [plasma membrane] (Canis familiaris)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Canis familiaris)
Focal complex [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Canis familiaris)
RAF/MAPK scaffolds [cytosol] (Canis familiaris)
Focal Adhesion/Focal contacts [plasma membrane] (Canis familiaris)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Canis familiaris)
Focal complex [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Dual mechanism MAP2K inhibitors bind MAP2Ks (Canis familiaris)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Canis familiaris)
RAF/MAPK scaffolds [cytosol] (Canis familiaris)
Focal Adhesion/Focal contacts [plasma membrane] (Canis familiaris)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Canis familiaris)
Focal complex [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Canis familiaris)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Canis familiaris)
RAF/MAPK scaffolds [cytosol] (Canis familiaris)
Focal Adhesion/Focal contacts [plasma membrane] (Canis familiaris)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Canis familiaris)
Focal complex [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Dual mechanism MAPK inhibitors bind MAPKs (Canis familiaris)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Canis familiaris)
RAF/MAPK scaffolds [cytosol] (Canis familiaris)
Focal Adhesion/Focal contacts [plasma membrane] (Canis familiaris)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Canis familiaris)
Focal complex [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors [plasma membrane] (Canis familiaris)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Canis familiaris)
RAF/MAPK scaffolds [cytosol] (Canis familiaris)
Focal Adhesion/Focal contacts [plasma membrane] (Canis familiaris)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Canis familiaris)
Focal complex [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
MAP2Ks and MAPKs bind to the activated RAF complex (Canis familiaris)
RAF/MAPK scaffolds [cytosol] (Canis familiaris)
Focal Adhesion/Focal contacts [plasma membrane] (Canis familiaris)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Canis familiaris)
Focal complex [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Canis familiaris)
RAF/MAPK scaffolds [cytosol] (Canis familiaris)
Focal Adhesion/Focal contacts [plasma membrane] (Canis familiaris)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Canis familiaris)
Focal complex [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
MAP2Ks phosphorylate MAPKs (Canis familiaris)
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Canis familiaris)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Canis familiaris)
RAF/MAPK scaffolds [cytosol] (Canis familiaris)
Focal Adhesion/Focal contacts [plasma membrane] (Canis familiaris)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Canis familiaris)
Focal complex [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Canis familiaris)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Canis familiaris)
RAF/MAPK scaffolds [cytosol] (Canis familiaris)
Focal Adhesion/Focal contacts [plasma membrane] (Canis familiaris)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Canis familiaris)
Focal complex [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Canis familiaris)
RAF/MAPK scaffolds [cytosol] (Canis familiaris)
Focal Adhesion/Focal contacts [plasma membrane] (Canis familiaris)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Canis familiaris)
Focal complex [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors [plasma membrane] (Canis familiaris)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Canis familiaris)
RAF/MAPK scaffolds [cytosol] (Canis familiaris)
Focal Adhesion/Focal contacts [plasma membrane] (Canis familiaris)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Canis familiaris)
Focal complex [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Canis familiaris)
RAF/MAPK scaffolds [cytosol] (Canis familiaris)
Focal Adhesion/Focal contacts [plasma membrane] (Canis familiaris)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Canis familiaris)
Focal complex [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
RAF phosphorylates MAP2K dimer (Canis familiaris)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Canis familiaris)
RAF/MAPK scaffolds [cytosol] (Canis familiaris)
Focal Adhesion/Focal contacts [plasma membrane] (Canis familiaris)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Canis familiaris)
Focal complex [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Canis familiaris)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Canis familiaris)
RAF/MAPK scaffolds [cytosol] (Canis familiaris)
Focal Adhesion/Focal contacts [plasma membrane] (Canis familiaris)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Canis familiaris)
Focal complex [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Canis familiaris)
RAF/MAPK scaffolds [cytosol] (Canis familiaris)
Focal Adhesion/Focal contacts [plasma membrane] (Canis familiaris)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Canis familiaris)
Focal complex [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks (Canis familiaris)
activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Canis familiaris)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Canis familiaris)
RAF/MAPK scaffolds [cytosol] (Canis familiaris)
Focal Adhesion/Focal contacts [plasma membrane] (Canis familiaris)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Canis familiaris)
Focal complex [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Canis familiaris)
RAF/MAPK scaffolds [cytosol] (Canis familiaris)
Focal Adhesion/Focal contacts [plasma membrane] (Canis familiaris)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Canis familiaris)
Focal complex [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Single mechanism MAPK inhibitors bind phosphorylated MAPK (Canis familiaris)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Canis familiaris)
RAF/MAPK scaffolds [cytosol] (Canis familiaris)
Focal Adhesion/Focal contacts [plasma membrane] (Canis familiaris)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Canis familiaris)
Focal complex [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK:single mechanism MAPK inhibitors [plasma membrane] (Canis familiaris)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Canis familiaris)
RAF/MAPK scaffolds [cytosol] (Canis familiaris)
Focal Adhesion/Focal contacts [plasma membrane] (Canis familiaris)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Canis familiaris)
Focal complex [plasma membrane] (Canis familiaris)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Transport of small molecules (Canis familiaris)
Miscellaneous transport and binding events (Canis familiaris)
MAGT1 transports Mg2+ from extracellular region to cytosol (Canis familiaris)
Mg2+ [extracellular region]
NIPAs transport Mg2+ from extracellular region to cytosol (Canis familiaris)
Mg2+ [extracellular region]
TUSC3 transports Mg2+ from extracellular region to cytosol (Canis familiaris)
Mg2+ [extracellular region]
SLC-mediated transmembrane transport (Canis familiaris)
Transport of bile salts and organic acids, metal ions and amine compounds (Canis familiaris)
Metal ion SLC transporters (Canis familiaris)
SLC41A1,2 transport Mg2+ from extracellular region to cytosol (Canis familiaris)
Mg2+ [extracellular region]
Hemostasis (Danio rerio)
Platelet activation, signaling and aggregation (Danio rerio)
Platelet Aggregation (Plug Formation) (Danio rerio)
Integrin signaling (Danio rerio)
Autophosphorylation of SRC (Danio rerio)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:SRC) [plasma membrane] (Danio rerio)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Danio rerio)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Clustering of Integrin alphaIIb beta3 complexes (Danio rerio)
Focal complex [plasma membrane] (Danio rerio)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Danio rerio)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Interaction of integrin alphaIIb beta3 with Fibrinogen (Danio rerio)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Focal complex [plasma membrane] (Danio rerio)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Release of CSK from SRC (Danio rerio)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:Inactive (p-Y530)-SRC) [plasma membrane] (Danio rerio)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Danio rerio)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Response to elevated platelet cytosolic Ca2+ (Danio rerio)
Platelet degranulation (Danio rerio)
Exocytosis of platelet dense granule content (Danio rerio)
Platelet dense granule content [extracellular region] (Danio rerio)
Mg2+ [extracellular region]
Platelet homeostasis (Danio rerio)
Platelet calcium homeostasis (Danio rerio)
Elevation of cytosolic Ca2+ levels (Danio rerio)
Cation influx mediated by TRPC3/6/7 (Danio rerio)
Cations [extracellular region]
Mg2+ [extracellular region]
Metabolism (Danio rerio)
Metabolism of nucleotides (Danio rerio)
Nucleotide catabolism (Danio rerio)
Phosphate bond hydrolysis by NTPDase proteins (Danio rerio)
NTPDase2 hydrolyzes nucleoside triphosphates (Danio rerio)
NTPDase2:Ca2+,Mg2+ [plasma membrane] (Danio rerio)
Ca2+,Mg2+ [extracellular region]
Mg2+ [extracellular region]
NTPDase6 hydrolyzes nucleoside diphosphates (Danio rerio)
NTPDase6:Ca2+,Mg2+ [extracellular region] (Danio rerio)
Ca2+,Mg2+ [extracellular region]
Mg2+ [extracellular region]
NTPDase8 hydrolyzes nucleoside diphosphates (Danio rerio)
NTPDase8:Ca2+,Mg2+ [plasma membrane] (Danio rerio)
Ca2+,Mg2+ [extracellular region]
Mg2+ [extracellular region]
NTPDase8 hydrolyzes nucleoside triphosphates (Danio rerio)
NTPDase8:Ca2+,Mg2+ [plasma membrane] (Danio rerio)
Ca2+,Mg2+ [extracellular region]
Mg2+ [extracellular region]
Signal Transduction (Danio rerio)
Integrin signaling (Danio rerio)
Autophosphorylation of SRC (Danio rerio)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:SRC) [plasma membrane] (Danio rerio)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Danio rerio)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Clustering of Integrin alphaIIb beta3 complexes (Danio rerio)
Focal complex [plasma membrane] (Danio rerio)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Danio rerio)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Interaction of integrin alphaIIb beta3 with Fibrinogen (Danio rerio)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Focal complex [plasma membrane] (Danio rerio)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Release of CSK from SRC (Danio rerio)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:Inactive (p-Y530)-SRC) [plasma membrane] (Danio rerio)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Danio rerio)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Transport of small molecules (Danio rerio)
Miscellaneous transport and binding events (Danio rerio)
MAGT1 transports Mg2+ from extracellular region to cytosol (Danio rerio)
Mg2+ [extracellular region]
NIPAs transport Mg2+ from extracellular region to cytosol (Danio rerio)
Mg2+ [extracellular region]
SLC-mediated transmembrane transport (Danio rerio)
Transport of bile salts and organic acids, metal ions and amine compounds (Danio rerio)
Metal ion SLC transporters (Danio rerio)
SLC41A1,2 transport Mg2+ from extracellular region to cytosol (Danio rerio)
Mg2+ [extracellular region]
Hemostasis (Dictyostelium discoideum)
Platelet activation, signaling and aggregation (Dictyostelium discoideum)
Response to elevated platelet cytosolic Ca2+ (Dictyostelium discoideum)
Platelet degranulation (Dictyostelium discoideum)
Exocytosis of platelet dense granule content (Dictyostelium discoideum)
Platelet dense granule content [extracellular region] (Dictyostelium discoideum)
Mg2+ [extracellular region]
Transport of small molecules (Dictyostelium discoideum)
Miscellaneous transport and binding events (Dictyostelium discoideum)
MAGT1 transports Mg2+ from extracellular region to cytosol (Dictyostelium discoideum)
Mg2+ [extracellular region]
TUSC3 transports Mg2+ from extracellular region to cytosol (Dictyostelium discoideum)
Mg2+ [extracellular region]
Hemostasis (Drosophila melanogaster)
Platelet activation, signaling and aggregation (Drosophila melanogaster)
Platelet Aggregation (Plug Formation) (Drosophila melanogaster)
Integrin signaling (Drosophila melanogaster)
Autophosphorylation of SRC (Drosophila melanogaster)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:SRC) [plasma membrane] (Drosophila melanogaster)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Drosophila melanogaster)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Clustering of Integrin alphaIIb beta3 complexes (Drosophila melanogaster)
Focal complex [plasma membrane] (Drosophila melanogaster)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Drosophila melanogaster)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Dephosphorylation of inactive SRC by PTPB1 (Drosophila melanogaster)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:Inactive (p-Y530)-SRC) [plasma membrane] (Drosophila melanogaster)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:SRC) [plasma membrane] (Drosophila melanogaster)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Interaction of integrin alphaIIb beta3 with Fibrinogen (Drosophila melanogaster)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Focal complex [plasma membrane] (Drosophila melanogaster)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Release of CSK from SRC (Drosophila melanogaster)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:Inactive (p-Y530)-SRC) [plasma membrane] (Drosophila melanogaster)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Drosophila melanogaster)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
SYK activation by SRC (Drosophila melanogaster)
Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane] (Drosophila melanogaster)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Drosophila melanogaster)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Talin:RIAM:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC):p(Y)-SYK [plasma membrane] (Drosophila melanogaster)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Drosophila melanogaster)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
SYK binds to integrin alphaIIb beta3 (Drosophila melanogaster)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Drosophila melanogaster)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane] (Drosophila melanogaster)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Drosophila melanogaster)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Response to elevated platelet cytosolic Ca2+ (Drosophila melanogaster)
Platelet degranulation (Drosophila melanogaster)
Exocytosis of platelet dense granule content (Drosophila melanogaster)
Platelet dense granule content [extracellular region] (Drosophila melanogaster)
Mg2+ [extracellular region]
Metabolism (Drosophila melanogaster)
Metabolism of nucleotides (Drosophila melanogaster)
Nucleotide catabolism (Drosophila melanogaster)
Phosphate bond hydrolysis by NTPDase proteins (Drosophila melanogaster)
NTPDase5 hydrolyzes nucleoside diphosphates (Drosophila melanogaster)
NPTDase5:Ca2+,Mg2+ [extracellular region] (Drosophila melanogaster)
Ca2+,Mg2+ [extracellular region]
Mg2+ [extracellular region]
NTPDase6 hydrolyzes nucleoside diphosphates (Drosophila melanogaster)
NTPDase6:Ca2+,Mg2+ [extracellular region] (Drosophila melanogaster)
Ca2+,Mg2+ [extracellular region]
Mg2+ [extracellular region]
Signal Transduction (Drosophila melanogaster)
Integrin signaling (Drosophila melanogaster)
Autophosphorylation of SRC (Drosophila melanogaster)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:SRC) [plasma membrane] (Drosophila melanogaster)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Drosophila melanogaster)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Clustering of Integrin alphaIIb beta3 complexes (Drosophila melanogaster)
Focal complex [plasma membrane] (Drosophila melanogaster)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Drosophila melanogaster)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Dephosphorylation of inactive SRC by PTPB1 (Drosophila melanogaster)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:Inactive (p-Y530)-SRC) [plasma membrane] (Drosophila melanogaster)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:SRC) [plasma membrane] (Drosophila melanogaster)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Interaction of integrin alphaIIb beta3 with Fibrinogen (Drosophila melanogaster)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Focal complex [plasma membrane] (Drosophila melanogaster)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Release of CSK from SRC (Drosophila melanogaster)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:Inactive (p-Y530)-SRC) [plasma membrane] (Drosophila melanogaster)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Drosophila melanogaster)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
SYK activation by SRC (Drosophila melanogaster)
Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane] (Drosophila melanogaster)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Drosophila melanogaster)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Talin:RIAM:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC):p(Y)-SYK [plasma membrane] (Drosophila melanogaster)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Drosophila melanogaster)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
SYK binds to integrin alphaIIb beta3 (Drosophila melanogaster)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Drosophila melanogaster)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane] (Drosophila melanogaster)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Drosophila melanogaster)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
MAPK family signaling cascades (Drosophila melanogaster)
MAPK1/MAPK3 signaling (Drosophila melanogaster)
RAF/MAP kinase cascade (Drosophila melanogaster)
MAP2K and MAPK activation (Drosophila melanogaster)
Dissociation of RAS:RAF complex (Drosophila melanogaster)
RAF/MAPK scaffolds [cytosol] (Drosophila melanogaster)
Focal Adhesion/Focal contacts [plasma membrane] (Drosophila melanogaster)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Drosophila melanogaster)
Focal complex [plasma membrane] (Drosophila melanogaster)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Drosophila melanogaster)
RAF/MAPK scaffolds [cytosol] (Drosophila melanogaster)
Focal Adhesion/Focal contacts [plasma membrane] (Drosophila melanogaster)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Drosophila melanogaster)
Focal complex [plasma membrane] (Drosophila melanogaster)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Dual mechanism MAP2K inhibitors bind MAP2Ks (Drosophila melanogaster)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Drosophila melanogaster)
RAF/MAPK scaffolds [cytosol] (Drosophila melanogaster)
Focal Adhesion/Focal contacts [plasma membrane] (Drosophila melanogaster)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Drosophila melanogaster)
Focal complex [plasma membrane] (Drosophila melanogaster)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Drosophila melanogaster)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Drosophila melanogaster)
RAF/MAPK scaffolds [cytosol] (Drosophila melanogaster)
Focal Adhesion/Focal contacts [plasma membrane] (Drosophila melanogaster)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Drosophila melanogaster)
Focal complex [plasma membrane] (Drosophila melanogaster)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Dual mechanism MAPK inhibitors bind MAPKs (Drosophila melanogaster)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Drosophila melanogaster)
RAF/MAPK scaffolds [cytosol] (Drosophila melanogaster)
Focal Adhesion/Focal contacts [plasma membrane] (Drosophila melanogaster)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Drosophila melanogaster)
Focal complex [plasma membrane] (Drosophila melanogaster)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors [plasma membrane] (Drosophila melanogaster)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Drosophila melanogaster)
RAF/MAPK scaffolds [cytosol] (Drosophila melanogaster)
Focal Adhesion/Focal contacts [plasma membrane] (Drosophila melanogaster)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Drosophila melanogaster)
Focal complex [plasma membrane] (Drosophila melanogaster)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
MAP2Ks and MAPKs bind to the activated RAF complex (Drosophila melanogaster)
RAF/MAPK scaffolds [cytosol] (Drosophila melanogaster)
Focal Adhesion/Focal contacts [plasma membrane] (Drosophila melanogaster)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Drosophila melanogaster)
Focal complex [plasma membrane] (Drosophila melanogaster)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Drosophila melanogaster)
RAF/MAPK scaffolds [cytosol] (Drosophila melanogaster)
Focal Adhesion/Focal contacts [plasma membrane] (Drosophila melanogaster)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Drosophila melanogaster)
Focal complex [plasma membrane] (Drosophila melanogaster)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
MAP2Ks phosphorylate MAPKs (Drosophila melanogaster)
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Drosophila melanogaster)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Drosophila melanogaster)
RAF/MAPK scaffolds [cytosol] (Drosophila melanogaster)
Focal Adhesion/Focal contacts [plasma membrane] (Drosophila melanogaster)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Drosophila melanogaster)
Focal complex [plasma membrane] (Drosophila melanogaster)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Drosophila melanogaster)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Drosophila melanogaster)
RAF/MAPK scaffolds [cytosol] (Drosophila melanogaster)
Focal Adhesion/Focal contacts [plasma membrane] (Drosophila melanogaster)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Drosophila melanogaster)
Focal complex [plasma membrane] (Drosophila melanogaster)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Drosophila melanogaster)
RAF/MAPK scaffolds [cytosol] (Drosophila melanogaster)
Focal Adhesion/Focal contacts [plasma membrane] (Drosophila melanogaster)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Drosophila melanogaster)
Focal complex [plasma membrane] (Drosophila melanogaster)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors [plasma membrane] (Drosophila melanogaster)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Drosophila melanogaster)
RAF/MAPK scaffolds [cytosol] (Drosophila melanogaster)
Focal Adhesion/Focal contacts [plasma membrane] (Drosophila melanogaster)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Drosophila melanogaster)
Focal complex [plasma membrane] (Drosophila melanogaster)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Drosophila melanogaster)
RAF/MAPK scaffolds [cytosol] (Drosophila melanogaster)
Focal Adhesion/Focal contacts [plasma membrane] (Drosophila melanogaster)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Drosophila melanogaster)
Focal complex [plasma membrane] (Drosophila melanogaster)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
RAF phosphorylates MAP2K dimer (Drosophila melanogaster)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Drosophila melanogaster)
RAF/MAPK scaffolds [cytosol] (Drosophila melanogaster)
Focal Adhesion/Focal contacts [plasma membrane] (Drosophila melanogaster)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Drosophila melanogaster)
Focal complex [plasma membrane] (Drosophila melanogaster)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Drosophila melanogaster)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Drosophila melanogaster)
RAF/MAPK scaffolds [cytosol] (Drosophila melanogaster)
Focal Adhesion/Focal contacts [plasma membrane] (Drosophila melanogaster)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Drosophila melanogaster)
Focal complex [plasma membrane] (Drosophila melanogaster)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Drosophila melanogaster)
RAF/MAPK scaffolds [cytosol] (Drosophila melanogaster)
Focal Adhesion/Focal contacts [plasma membrane] (Drosophila melanogaster)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Drosophila melanogaster)
Focal complex [plasma membrane] (Drosophila melanogaster)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks (Drosophila melanogaster)
activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Drosophila melanogaster)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Drosophila melanogaster)
RAF/MAPK scaffolds [cytosol] (Drosophila melanogaster)
Focal Adhesion/Focal contacts [plasma membrane] (Drosophila melanogaster)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Drosophila melanogaster)
Focal complex [plasma membrane] (Drosophila melanogaster)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Drosophila melanogaster)
RAF/MAPK scaffolds [cytosol] (Drosophila melanogaster)
Focal Adhesion/Focal contacts [plasma membrane] (Drosophila melanogaster)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Drosophila melanogaster)
Focal complex [plasma membrane] (Drosophila melanogaster)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Single mechanism MAPK inhibitors bind phosphorylated MAPK (Drosophila melanogaster)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Drosophila melanogaster)
RAF/MAPK scaffolds [cytosol] (Drosophila melanogaster)
Focal Adhesion/Focal contacts [plasma membrane] (Drosophila melanogaster)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Drosophila melanogaster)
Focal complex [plasma membrane] (Drosophila melanogaster)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK:single mechanism MAPK inhibitors [plasma membrane] (Drosophila melanogaster)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Drosophila melanogaster)
RAF/MAPK scaffolds [cytosol] (Drosophila melanogaster)
Focal Adhesion/Focal contacts [plasma membrane] (Drosophila melanogaster)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Drosophila melanogaster)
Focal complex [plasma membrane] (Drosophila melanogaster)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Transport of small molecules (Drosophila melanogaster)
Miscellaneous transport and binding events (Drosophila melanogaster)
MAGT1 transports Mg2+ from extracellular region to cytosol (Drosophila melanogaster)
Mg2+ [extracellular region]
NIPAs transport Mg2+ from extracellular region to cytosol (Drosophila melanogaster)
Mg2+ [extracellular region]
TUSC3 transports Mg2+ from extracellular region to cytosol (Drosophila melanogaster)
Mg2+ [extracellular region]
SLC-mediated transmembrane transport (Drosophila melanogaster)
Transport of bile salts and organic acids, metal ions and amine compounds (Drosophila melanogaster)
Metal ion SLC transporters (Drosophila melanogaster)
SLC41A1,2 transport Mg2+ from extracellular region to cytosol (Drosophila melanogaster)
Mg2+ [extracellular region]
Extracellular matrix organization (Gallus gallus)
Integrin cell surface interactions (Gallus gallus)
Collagen type I binds integrin alpha11beta1 (Gallus gallus)
Mg2+ [extracellular region]
Collagen type I:Mg2+:Integrin alpha 11 beta 1 [plasma membrane] (Gallus gallus)
Mg2+ [extracellular region]
Interaction of integrin alphaDbeta2 with fibrin (Gallus gallus)
Mg2+ [extracellular region]
Integrin alphaDbeta2:fibrin multimer:Mg++ [plasma membrane] (Gallus gallus)
Mg2+ [extracellular region]
Hemostasis (Gallus gallus)
Platelet activation, signaling and aggregation (Gallus gallus)
Platelet Aggregation (Plug Formation) (Gallus gallus)
Integrin signaling (Gallus gallus)
Autophosphorylation of PTK2 at Y397 (Gallus gallus)
Talin:RIAM complex: ECM ligands:Integrin alphaIIb beta3:Active (p-Y419)- SRC:PTK2 [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Talin:RIAM complex:ECM ligands: alphaIIb beta3:Active p-Y419-SRC:pY397-PTK2 [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Autophosphorylation of SRC (Gallus gallus)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:SRC) [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Clustering of Integrin alphaIIb beta3 complexes (Gallus gallus)
Focal complex [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Dephosphorylation of inactive SRC by PTPB1 (Gallus gallus)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:Inactive (p-Y530)-SRC) [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:SRC) [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
GRB2:SOS provides linkage to MAPK signaling for Integrins (Gallus gallus)
Interaction of SOS with GRB2 bound to FADK1 (Gallus gallus)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
GRB2:SOS:p-PTK2:Focal adhesion [plasma membrane] (Gallus gallus)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Recruitment of GRB2 to p-PTK2 (Gallus gallus)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Interaction of integrin alphaIIb beta3 with Fibrinogen (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Focal complex [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Phosphorylation of pPTK2 by SRC (Gallus gallus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Talin:RIAM complex:ECM ligands: alphaIIb beta3:Active p-Y419-SRC:pY397-PTK2 [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Release of CSK from SRC (Gallus gallus)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:Inactive (p-Y530)-SRC) [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
SYK activation by SRC (Gallus gallus)
Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Talin:RIAM:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC):p(Y)-SYK [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
SYK binds to integrin alphaIIb beta3 (Gallus gallus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Translocation of PTK2 to Focal complexes (Gallus gallus)
Talin:RIAM complex: ECM ligands:Integrin alphaIIb beta3:Active (p-Y419)- SRC:PTK2 [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
p130Cas linkage to MAPK signaling for integrins (Gallus gallus)
Crk binding to p130cas (Gallus gallus)
CRK:p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Gallus gallus)
p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Phosphorylation of BCAR1 by SRC-PTK2 complex (Gallus gallus)
BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Recruitment of BCAR1 to PTK2 complex (Gallus gallus)
BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Response to elevated platelet cytosolic Ca2+ (Gallus gallus)
Platelet degranulation (Gallus gallus)
Exocytosis of platelet dense granule content (Gallus gallus)
Platelet dense granule content [extracellular region] (Gallus gallus)
Mg2+ [extracellular region]
Platelet homeostasis (Gallus gallus)
Platelet calcium homeostasis (Gallus gallus)
Elevation of cytosolic Ca2+ levels (Gallus gallus)
Cation influx mediated by TRPC3/6/7 (Gallus gallus)
Cations [extracellular region]
Mg2+ [extracellular region]
Innate Immune System (Gallus gallus)
Complement Cascade (Gallus gallus)
Creation of alternative pathway C3 convertase (Gallus gallus)
Formation of membrane-bound convertase C3 (Gallus gallus)
Complement factor B binds to surface-bound C3b fragment (Gallus gallus)
Mg2+ [extracellular region]
Creation of classical C3 convertase (Gallus gallus)
Formation of C4b:factor B complex (Gallus gallus)
Mg2+ [extracellular region]
Metabolism (Gallus gallus)
Metabolism of nucleotides (Gallus gallus)
Nucleotide catabolism (Gallus gallus)
Phosphate bond hydrolysis by NTPDase proteins (Gallus gallus)
NTPDase1 hydrolyzes nucleoside diphosphates (Gallus gallus)
NTPDase1:Ca2+,Mg2+ [plasma membrane] (Gallus gallus)
Ca2+,Mg2+ [extracellular region]
Mg2+ [extracellular region]
NTPDase1 hydrolyzes nucleoside triphosphates (Gallus gallus)
NTPDase1:Ca2+,Mg2+ [plasma membrane] (Gallus gallus)
Ca2+,Mg2+ [extracellular region]
Mg2+ [extracellular region]
NTPDase2 hydrolyzes nucleoside triphosphates (Gallus gallus)
NTPDase2:Ca2+,Mg2+ [plasma membrane] (Gallus gallus)
Ca2+,Mg2+ [extracellular region]
Mg2+ [extracellular region]
NTPDase3 hydrolyzes nucleoside diphosphates (Gallus gallus)
NTPDase3:Ca2+,Mg2+ [plasma membrane] (Gallus gallus)
Ca2+,Mg2+ [extracellular region]
Mg2+ [extracellular region]
NTPDase3 hydrolyzes nucleoside triphosphates (Gallus gallus)
NTPDase3:Ca2+,Mg2+ [plasma membrane] (Gallus gallus)
Ca2+,Mg2+ [extracellular region]
Mg2+ [extracellular region]
NTPDase5 hydrolyzes nucleoside diphosphates (Gallus gallus)
NPTDase5:Ca2+,Mg2+ [extracellular region] (Gallus gallus)
Ca2+,Mg2+ [extracellular region]
Mg2+ [extracellular region]
NTPDase6 hydrolyzes nucleoside diphosphates (Gallus gallus)
NTPDase6:Ca2+,Mg2+ [extracellular region] (Gallus gallus)
Ca2+,Mg2+ [extracellular region]
Mg2+ [extracellular region]
NTPDase8 hydrolyzes nucleoside diphosphates (Gallus gallus)
NTPDase8:Ca2+,Mg2+ [plasma membrane] (Gallus gallus)
Ca2+,Mg2+ [extracellular region]
Mg2+ [extracellular region]
NTPDase8 hydrolyzes nucleoside triphosphates (Gallus gallus)
NTPDase8:Ca2+,Mg2+ [plasma membrane] (Gallus gallus)
Ca2+,Mg2+ [extracellular region]
Mg2+ [extracellular region]
Signal Transduction (Gallus gallus)
Integrin signaling (Gallus gallus)
Autophosphorylation of PTK2 at Y397 (Gallus gallus)
Talin:RIAM complex: ECM ligands:Integrin alphaIIb beta3:Active (p-Y419)- SRC:PTK2 [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Talin:RIAM complex:ECM ligands: alphaIIb beta3:Active p-Y419-SRC:pY397-PTK2 [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Autophosphorylation of SRC (Gallus gallus)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:SRC) [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Clustering of Integrin alphaIIb beta3 complexes (Gallus gallus)
Focal complex [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Dephosphorylation of inactive SRC by PTPB1 (Gallus gallus)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:Inactive (p-Y530)-SRC) [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:SRC) [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
GRB2:SOS provides linkage to MAPK signaling for Integrins (Gallus gallus)
Interaction of SOS with GRB2 bound to FADK1 (Gallus gallus)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
GRB2:SOS:p-PTK2:Focal adhesion [plasma membrane] (Gallus gallus)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Recruitment of GRB2 to p-PTK2 (Gallus gallus)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Interaction of integrin alphaIIb beta3 with Fibrinogen (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Focal complex [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Phosphorylation of pPTK2 by SRC (Gallus gallus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Talin:RIAM complex:ECM ligands: alphaIIb beta3:Active p-Y419-SRC:pY397-PTK2 [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Release of CSK from SRC (Gallus gallus)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:Inactive (p-Y530)-SRC) [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
SYK activation by SRC (Gallus gallus)
Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Talin:RIAM:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC):p(Y)-SYK [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
SYK binds to integrin alphaIIb beta3 (Gallus gallus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Translocation of PTK2 to Focal complexes (Gallus gallus)
Talin:RIAM complex: ECM ligands:Integrin alphaIIb beta3:Active (p-Y419)- SRC:PTK2 [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
p130Cas linkage to MAPK signaling for integrins (Gallus gallus)
Crk binding to p130cas (Gallus gallus)
CRK:p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Gallus gallus)
p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Phosphorylation of BCAR1 by SRC-PTK2 complex (Gallus gallus)
BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Recruitment of BCAR1 to PTK2 complex (Gallus gallus)
BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
MAPK family signaling cascades (Gallus gallus)
MAPK1/MAPK3 signaling (Gallus gallus)
RAF/MAP kinase cascade (Gallus gallus)
MAP2K and MAPK activation (Gallus gallus)
Dissociation of RAS:RAF complex (Gallus gallus)
RAF/MAPK scaffolds [cytosol] (Gallus gallus)
Focal Adhesion/Focal contacts [plasma membrane] (Gallus gallus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Gallus gallus)
Focal complex [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Gallus gallus)
RAF/MAPK scaffolds [cytosol] (Gallus gallus)
Focal Adhesion/Focal contacts [plasma membrane] (Gallus gallus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Gallus gallus)
Focal complex [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Dual mechanism MAP2K inhibitors bind MAP2Ks (Gallus gallus)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Gallus gallus)
RAF/MAPK scaffolds [cytosol] (Gallus gallus)
Focal Adhesion/Focal contacts [plasma membrane] (Gallus gallus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Gallus gallus)
Focal complex [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Gallus gallus)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Gallus gallus)
RAF/MAPK scaffolds [cytosol] (Gallus gallus)
Focal Adhesion/Focal contacts [plasma membrane] (Gallus gallus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Gallus gallus)
Focal complex [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Dual mechanism MAPK inhibitors bind MAPKs (Gallus gallus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Gallus gallus)
RAF/MAPK scaffolds [cytosol] (Gallus gallus)
Focal Adhesion/Focal contacts [plasma membrane] (Gallus gallus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Gallus gallus)
Focal complex [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors [plasma membrane] (Gallus gallus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Gallus gallus)
RAF/MAPK scaffolds [cytosol] (Gallus gallus)
Focal Adhesion/Focal contacts [plasma membrane] (Gallus gallus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Gallus gallus)
Focal complex [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
MAP2Ks and MAPKs bind to the activated RAF complex (Gallus gallus)
RAF/MAPK scaffolds [cytosol] (Gallus gallus)
Focal Adhesion/Focal contacts [plasma membrane] (Gallus gallus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Gallus gallus)
Focal complex [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Gallus gallus)
RAF/MAPK scaffolds [cytosol] (Gallus gallus)
Focal Adhesion/Focal contacts [plasma membrane] (Gallus gallus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Gallus gallus)
Focal complex [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
MAP2Ks phosphorylate MAPKs (Gallus gallus)
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Gallus gallus)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Gallus gallus)
RAF/MAPK scaffolds [cytosol] (Gallus gallus)
Focal Adhesion/Focal contacts [plasma membrane] (Gallus gallus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Gallus gallus)
Focal complex [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Gallus gallus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Gallus gallus)
RAF/MAPK scaffolds [cytosol] (Gallus gallus)
Focal Adhesion/Focal contacts [plasma membrane] (Gallus gallus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Gallus gallus)
Focal complex [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Gallus gallus)
RAF/MAPK scaffolds [cytosol] (Gallus gallus)
Focal Adhesion/Focal contacts [plasma membrane] (Gallus gallus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Gallus gallus)
Focal complex [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors [plasma membrane] (Gallus gallus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Gallus gallus)
RAF/MAPK scaffolds [cytosol] (Gallus gallus)
Focal Adhesion/Focal contacts [plasma membrane] (Gallus gallus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Gallus gallus)
Focal complex [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Gallus gallus)
RAF/MAPK scaffolds [cytosol] (Gallus gallus)
Focal Adhesion/Focal contacts [plasma membrane] (Gallus gallus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Gallus gallus)
Focal complex [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
RAF phosphorylates MAP2K dimer (Gallus gallus)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Gallus gallus)
RAF/MAPK scaffolds [cytosol] (Gallus gallus)
Focal Adhesion/Focal contacts [plasma membrane] (Gallus gallus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Gallus gallus)
Focal complex [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Gallus gallus)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Gallus gallus)
RAF/MAPK scaffolds [cytosol] (Gallus gallus)
Focal Adhesion/Focal contacts [plasma membrane] (Gallus gallus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Gallus gallus)
Focal complex [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Gallus gallus)
RAF/MAPK scaffolds [cytosol] (Gallus gallus)
Focal Adhesion/Focal contacts [plasma membrane] (Gallus gallus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Gallus gallus)
Focal complex [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks (Gallus gallus)
activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Gallus gallus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Gallus gallus)
RAF/MAPK scaffolds [cytosol] (Gallus gallus)
Focal Adhesion/Focal contacts [plasma membrane] (Gallus gallus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Gallus gallus)
Focal complex [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Gallus gallus)
RAF/MAPK scaffolds [cytosol] (Gallus gallus)
Focal Adhesion/Focal contacts [plasma membrane] (Gallus gallus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Gallus gallus)
Focal complex [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Single mechanism MAPK inhibitors bind phosphorylated MAPK (Gallus gallus)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Gallus gallus)
RAF/MAPK scaffolds [cytosol] (Gallus gallus)
Focal Adhesion/Focal contacts [plasma membrane] (Gallus gallus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Gallus gallus)
Focal complex [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK:single mechanism MAPK inhibitors [plasma membrane] (Gallus gallus)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Gallus gallus)
RAF/MAPK scaffolds [cytosol] (Gallus gallus)
Focal Adhesion/Focal contacts [plasma membrane] (Gallus gallus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Gallus gallus)
Focal complex [plasma membrane] (Gallus gallus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Transport of small molecules (Gallus gallus)
Miscellaneous transport and binding events (Gallus gallus)
MAGT1 transports Mg2+ from extracellular region to cytosol (Gallus gallus)
Mg2+ [extracellular region]
NIPAs transport Mg2+ from extracellular region to cytosol (Gallus gallus)
Mg2+ [extracellular region]
TUSC3 transports Mg2+ from extracellular region to cytosol (Gallus gallus)
Mg2+ [extracellular region]
SLC-mediated transmembrane transport (Gallus gallus)
Transport of bile salts and organic acids, metal ions and amine compounds (Gallus gallus)
Metal ion SLC transporters (Gallus gallus)
SLC41A1,2 transport Mg2+ from extracellular region to cytosol (Gallus gallus)
Mg2+ [extracellular region]
Disease (Homo sapiens)
Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
Oncogenic MAPK signaling (Homo sapiens)
Paradoxical activation of RAF signaling by kinase inactive BRAF (Homo sapiens)
Activated MAP2Ks phosphorylate MAPKs downstream of inactive BRAF mutants (Homo sapiens)
RAS:GTP: inactive p-RAF:p-2S MAP2Ks:MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
RAS:GTP:inactive p-RAF:p-2S MAP2Ks:p-T,Y MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Dissociation of paradoxically activated RAS:BRAF complexes (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
RAS:GTP:inactive p-RAF:p-2S MAP2Ks:p-T,Y MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
RAS:GTP:inactive p-RAF complexes phosphorylate MAP2Ks (Homo sapiens)
RAS:GTP: inactive p-RAF:p-2S MAP2Ks:MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
RAS:GTP:inactive p-RAF:MAP2Ks:MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
RAS:GTP:p-RAF complexes paradoxically bind MAP2Ks and MAPKs (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
RAS:GTP:inactive p-RAF:MAP2Ks:MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Signaling by BRAF and RAF1 fusions (Homo sapiens)
Dissociation of BRAF/RAF fusion complex (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
p-BRAF/RAF fusion dimers:p-2S MAP2Ks:p-T,Y MAPKs:scaffold proteins [cytosol] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
MAPKs are phosphorylated downstream of BRAF and RAF fusion dimers (Homo sapiens)
p-BRAF/RAF fusion dimers:p-2S MAP2Ks:MAPKs:scaffold proteins [cytosol] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
p-BRAF/RAF fusion dimers:p-2S MAP2Ks:p-T,Y MAPKs:scaffold proteins [cytosol] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
p-BRAF and RAF fusion dimers bind MAP2Ks and MAPKs (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
p-BRAF/RAF fusion dimers:MAP2Ks:MAPKs:scaffold proteins [cytosol] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
p-BRAF and RAF fusion dimers phosphorylate MAP2Ks (Homo sapiens)
p-BRAF/RAF fusion dimers:MAP2Ks:MAPKs:scaffold proteins [cytosol] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
p-BRAF/RAF fusion dimers:p-2S MAP2Ks:MAPKs:scaffold proteins [cytosol] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Signaling by RAF1 mutants (Homo sapiens)
Dissociation of RAS:RAF1 mutant complex (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
activated RAF1 mutant:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
MAP2Ks and MAPKs bind to the activated mutant RAF1 complex (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
activated RAF1 mutant:scaffold:MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
MAP2Ks phosphorylate MAPKs downstream of RAF1 mutants (Homo sapiens)
activated RAF1 mutant:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
activated RAF1 mutant:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
RAF1 mutant complexes phosphorylate MAP2K dimer (Homo sapiens)
activated RAF1 mutant:scaffold:MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
activated RAF1 mutant:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Signaling by RAS mutants (Homo sapiens)
Signaling downstream of RAS mutants (Homo sapiens)
Activated MAP2Ks phosphorylate MAPKs downstream of oncogenic RAS (Homo sapiens)
mutant RAS:GTP:p-RAF:p-2S MAP2Ks:MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
mutant RAS:GTP:p-RAF:p-2S MAP2Ks:p-T,Y MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Dissociation of oncogenic RAS:RAF complex (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
mutant RAS:GTP:p-RAF:p-2S MAP2Ks:p-T,Y MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Mutant RAS:p-RAF complexes bind MAP2Ks and MAPKs (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
mutant RAS:GTP:p-RAF:MAP2Ks:MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Mutant RAS:p-RAF complexes phosphorylate MAP2Ks (Homo sapiens)
mutant RAS:GTP:p-RAF:MAP2Ks:MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
mutant RAS:GTP:p-RAF:p-2S MAP2Ks:MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Signaling by high-kinase activity BRAF mutants (Homo sapiens)
Activated MAP2Ks phosphorylate MAPKs downstream of high kinase activity BRAF mutants (Homo sapiens)
high kinase activity BRAF mutants:scaffold:p-2S MAP2K:MAPK complex [cytosol] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
high kinase activity BRAF mutants:scaffold:p-2S MAP2K:p-T,Y MAPK complex [cytosol] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Dissociation of high activity BRAF complexes (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
high kinase activity BRAF mutants:scaffold:p-2S MAP2K:p-T,Y MAPK complex [cytosol] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
High kinase activity BRAF complexes phosphorylate MAP2Ks (Homo sapiens)
high kinase activity BRAF mutants:scaffold:MAP2K:MAPK complex [cytosol] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
high kinase activity BRAF mutants:scaffold:p-2S MAP2K:MAPK complex [cytosol] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
High kinase activity BRAF mutants bind MAP2Ks and MAPKs (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
high kinase activity BRAF mutants:scaffold:MAP2K:MAPK complex [cytosol] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Signaling by moderate kinase activity BRAF mutants (Homo sapiens)
Activated MAP2Ks phosphorylate MAPKs downstream of moderate kinase activity BRAF mutants (Homo sapiens)
RAS:GTP:moderate kinase activity p-RAF:p-2S MAP2Ks:MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
RAS:GTP:moderate kinase activity p-RAF:p-2S MAP2Ks:p-T,Y MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Dissociation of moderate activity BRAF complexes (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
RAS:GTP:moderate kinase activity p-RAF:p-2S MAP2Ks:p-T,Y MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
RAS:GTP:moderate kinase activity p-RAF complexes bind MAP2Ks and MAPKs (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
RAS:GTP:moderate kinase activity p-RAF:MAP2Ks:MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
RAS:GTP:moderate kinase activity p-RAF complexes phosphorylate MAP2Ks (Homo sapiens)
RAS:GTP:moderate kinase activity p-RAF:MAP2Ks:MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
RAS:GTP:moderate kinase activity p-RAF:p-2S MAP2Ks:MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Infectious disease (Homo sapiens)
Parasitic Infection Pathways (Homo sapiens)
Leishmania infection (Homo sapiens)
Cell recruitment (pro-inflammatory response) (Homo sapiens)
Purinergic signaling in leishmaniasis infection (Homo sapiens)
NTPDase1 hydrolyzes nucleoside triphosphates (Homo sapiens)
NTPDase1:Ca2+,Mg2+ [plasma membrane] (Homo sapiens)
Ca2+,Mg2+ [extracellular region]
Mg2+ [extracellular region]
NTPDase5 hydrolyzes nucleoside diphosphates (Homo sapiens)
NPTDase5:Ca2+,Mg2+ [extracellular region] (Homo sapiens)
Ca2+,Mg2+ [extracellular region]
Mg2+ [extracellular region]
Extracellular matrix organization (Homo sapiens)
Integrin cell surface interactions (Homo sapiens)
Collagen type I binds integrin alpha11beta1 (Homo sapiens)
Mg2+ [extracellular region]
Collagen type I:Mg2+:Integrin alpha 11 beta 1 [plasma membrane] (Homo sapiens)
Mg2+ [extracellular region]
Collagen type I binds integrin alpha1beta1, alpha2beta1, alpha10beta1 (Homo sapiens)
Mg2+ [extracellular region]
Collagen type II binds integrin alpha10beta1 (Homo sapiens)
Mg2+ [extracellular region]
Integrin alpha10beta1:Collagen type II fibril:Mg2+ [plasma membrane] (Homo sapiens)
Mg2+ [extracellular region]
Collagen type IV networks bind integrins alpha1beta1, alpha2beta1 (Homo sapiens)
Mg2+ [extracellular region]
Integrins alpha1beta1, alpha2beta1:Collagen type IV networks:Mg2+ [plasma membrane] (Homo sapiens)
Mg2+ [extracellular region]
Interaction of integrin alphaDbeta2 with fibrin (Homo sapiens)
Mg2+ [extracellular region]
Integrin alphaDbeta2:fibrin multimer:Mg++ [plasma membrane] (Homo sapiens)
Mg2+ [extracellular region]
Hemostasis (Homo sapiens)
Platelet Adhesion to exposed collagen (Homo sapiens)
Collagen type I binds integrin alpha1beta1, alpha2beta1, alpha10beta1 (Homo sapiens)
Mg2+ [extracellular region]
Platelet activation, signaling and aggregation (Homo sapiens)
Platelet Aggregation (Plug Formation) (Homo sapiens)
Integrin signaling (Homo sapiens)
Autophosphorylation of PTK2 at Y397 (Homo sapiens)
Talin:RIAM complex: ECM ligands:Integrin alphaIIb beta3:Active (p-Y419)- SRC:PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Talin:RIAM complex:ECM ligands: alphaIIb beta3:Active p-Y419-SRC:pY397-PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Autophosphorylation of SRC (Homo sapiens)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:SRC) [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Clustering of Integrin alphaIIb beta3 complexes (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Dephosphorylation of inactive SRC by PTPB1 (Homo sapiens)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:Inactive (p-Y530)-SRC) [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:SRC) [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
GRB2:SOS provides linkage to MAPK signaling for Integrins (Homo sapiens)
Interaction of SOS with GRB2 bound to FADK1 (Homo sapiens)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
GRB2:SOS:p-PTK2:Focal adhesion [plasma membrane] (Homo sapiens)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Recruitment of GRB2 to p-PTK2 (Homo sapiens)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Interaction of integrin alphaIIb beta3 with Fibrinogen (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Focal complex [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Phosphorylation of pPTK2 by SRC (Homo sapiens)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Talin:RIAM complex:ECM ligands: alphaIIb beta3:Active p-Y419-SRC:pY397-PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Release of CSK from SRC (Homo sapiens)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:Inactive (p-Y530)-SRC) [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
SYK activation by SRC (Homo sapiens)
Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Talin:RIAM:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC):p(Y)-SYK [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
SYK binds to integrin alphaIIb beta3 (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Translocation of PTK2 to Focal complexes (Homo sapiens)
Talin:RIAM complex: ECM ligands:Integrin alphaIIb beta3:Active (p-Y419)- SRC:PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
p130Cas linkage to MAPK signaling for integrins (Homo sapiens)
Crk binding to p130cas (Homo sapiens)
CRK:p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Phosphorylation of BCAR1 by SRC-PTK2 complex (Homo sapiens)
BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Recruitment of BCAR1 to PTK2 complex (Homo sapiens)
BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Response to elevated platelet cytosolic Ca2+ (Homo sapiens)
Platelet degranulation (Homo sapiens)
Exocytosis of platelet dense granule content (Homo sapiens)
Platelet dense granule content [extracellular region] (Homo sapiens)
Mg2+ [extracellular region]
Platelet homeostasis (Homo sapiens)
Platelet calcium homeostasis (Homo sapiens)
Elevation of cytosolic Ca2+ levels (Homo sapiens)
Cation influx mediated by TRPC3/6/7 (Homo sapiens)
Cations [extracellular region]
Mg2+ [extracellular region]
Metabolism (Homo sapiens)
Metabolism of nucleotides (Homo sapiens)
Nucleotide catabolism (Homo sapiens)
Phosphate bond hydrolysis by NTPDase proteins (Homo sapiens)
NTPDase1 hydrolyzes nucleoside diphosphates (Homo sapiens)
NTPDase1:Ca2+,Mg2+ [plasma membrane] (Homo sapiens)
Ca2+,Mg2+ [extracellular region]
Mg2+ [extracellular region]
NTPDase1 hydrolyzes nucleoside triphosphates (Homo sapiens)
NTPDase1:Ca2+,Mg2+ [plasma membrane] (Homo sapiens)
Ca2+,Mg2+ [extracellular region]
Mg2+ [extracellular region]
NTPDase2 hydrolyzes nucleoside triphosphates (Homo sapiens)
NTPDase2:Ca2+,Mg2+ [plasma membrane] (Homo sapiens)
Ca2+,Mg2+ [extracellular region]
Mg2+ [extracellular region]
NTPDase3 hydrolyzes nucleoside diphosphates (Homo sapiens)
NTPDase3:Ca2+,Mg2+ [plasma membrane] (Homo sapiens)
Ca2+,Mg2+ [extracellular region]
Mg2+ [extracellular region]
NTPDase3 hydrolyzes nucleoside triphosphates (Homo sapiens)
NTPDase3:Ca2+,Mg2+ [plasma membrane] (Homo sapiens)
Ca2+,Mg2+ [extracellular region]
Mg2+ [extracellular region]
NTPDase5 hydrolyzes nucleoside diphosphates (Homo sapiens)
NPTDase5:Ca2+,Mg2+ [extracellular region] (Homo sapiens)
Ca2+,Mg2+ [extracellular region]
Mg2+ [extracellular region]
NTPDase6 hydrolyzes nucleoside diphosphates (Homo sapiens)
NTPDase6:Ca2+,Mg2+ [extracellular region] (Homo sapiens)
Ca2+,Mg2+ [extracellular region]
Mg2+ [extracellular region]
NTPDase8 hydrolyzes nucleoside diphosphates (Homo sapiens)
NTPDase8:Ca2+,Mg2+ [plasma membrane] (Homo sapiens)
Ca2+,Mg2+ [extracellular region]
Mg2+ [extracellular region]
NTPDase8 hydrolyzes nucleoside triphosphates (Homo sapiens)
NTPDase8:Ca2+,Mg2+ [plasma membrane] (Homo sapiens)
Ca2+,Mg2+ [extracellular region]
Mg2+ [extracellular region]
Neuronal System (Homo sapiens)
Transmission across Chemical Synapses (Homo sapiens)
Neurotransmitter receptors and postsynaptic signal transmission (Homo sapiens)
Activation of NMDA receptors and postsynaptic events (Homo sapiens)
Unblocking of NMDA receptors, glutamate binding and activation (Homo sapiens)
Glycine and glutamate ligands bind GRIN1:GRIN2 NMDA receptor (Homo sapiens)
GRIN1:GRIN2 NMDA receptors:PSD proteins:Mg2+ [plasma membrane] (Homo sapiens)
Mg2+ [extracellular region]
Gly,D-Ser:L-Glu:GRIN1:GRIN2 NMDA receptors:PSD proteins:Mg2+ [plasma membrane] (Homo sapiens)
GRIN1:GRIN2 NMDA receptors:PSD proteins:Mg2+ [plasma membrane] (Homo sapiens)
Mg2+ [extracellular region]
Mg2+ binds GRIN1:GRIN2 NMDA receptors (Homo sapiens)
Mg2+ [extracellular region]
GRIN1:GRIN2 NMDA receptors:PSD proteins:Mg2+ [plasma membrane] (Homo sapiens)
Mg2+ [extracellular region]
Unblocking of GRIN1:GRIN2 NMDA receptors (Homo sapiens)
Mg2+ [extracellular region]
Gly,D-Ser:L-Glu:GRIN1:GRIN2 NMDA receptors:PSD proteins:Mg2+ [plasma membrane] (Homo sapiens)
GRIN1:GRIN2 NMDA receptors:PSD proteins:Mg2+ [plasma membrane] (Homo sapiens)
Mg2+ [extracellular region]
Signal Transduction (Homo sapiens)
Integrin signaling (Homo sapiens)
Autophosphorylation of PTK2 at Y397 (Homo sapiens)
Talin:RIAM complex: ECM ligands:Integrin alphaIIb beta3:Active (p-Y419)- SRC:PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Talin:RIAM complex:ECM ligands: alphaIIb beta3:Active p-Y419-SRC:pY397-PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Autophosphorylation of SRC (Homo sapiens)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:SRC) [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Clustering of Integrin alphaIIb beta3 complexes (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Dephosphorylation of inactive SRC by PTPB1 (Homo sapiens)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:Inactive (p-Y530)-SRC) [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:SRC) [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
GRB2:SOS provides linkage to MAPK signaling for Integrins (Homo sapiens)
Interaction of SOS with GRB2 bound to FADK1 (Homo sapiens)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
GRB2:SOS:p-PTK2:Focal adhesion [plasma membrane] (Homo sapiens)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Recruitment of GRB2 to p-PTK2 (Homo sapiens)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Interaction of integrin alphaIIb beta3 with Fibrinogen (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Focal complex [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Phosphorylation of pPTK2 by SRC (Homo sapiens)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Talin:RIAM complex:ECM ligands: alphaIIb beta3:Active p-Y419-SRC:pY397-PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Release of CSK from SRC (Homo sapiens)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:Inactive (p-Y530)-SRC) [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
SYK activation by SRC (Homo sapiens)
Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Talin:RIAM:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC):p(Y)-SYK [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
SYK binds to integrin alphaIIb beta3 (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Translocation of PTK2 to Focal complexes (Homo sapiens)
Talin:RIAM complex: ECM ligands:Integrin alphaIIb beta3:Active (p-Y419)- SRC:PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
p130Cas linkage to MAPK signaling for integrins (Homo sapiens)
Crk binding to p130cas (Homo sapiens)
CRK:p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Phosphorylation of BCAR1 by SRC-PTK2 complex (Homo sapiens)
BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Recruitment of BCAR1 to PTK2 complex (Homo sapiens)
BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
MAPK family signaling cascades (Homo sapiens)
MAPK1/MAPK3 signaling (Homo sapiens)
RAF/MAP kinase cascade (Homo sapiens)
MAP2K and MAPK activation (Homo sapiens)
Dissociation of RAS:RAF complex (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Dual mechanism MAP2K inhibitors bind MAP2Ks (Homo sapiens)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Homo sapiens)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Dual mechanism MAPK inhibitors bind MAPKs (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors [plasma membrane] (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
MAP2Ks and MAPKs bind to the activated RAF complex (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
MAP2Ks phosphorylate MAPKs (Homo sapiens)
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Homo sapiens)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors [plasma membrane] (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
RAF phosphorylates MAP2K dimer (Homo sapiens)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Homo sapiens)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Single mechanism MAPK inhibitors bind phosphorylated MAPK (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK:single mechanism MAPK inhibitors [plasma membrane] (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Transport of small molecules (Homo sapiens)
Miscellaneous transport and binding events (Homo sapiens)
MAGT1 transports Mg2+ from extracellular region to cytosol (Homo sapiens)
Mg2+ [extracellular region]
NIPAs transport Mg2+ from extracellular region to cytosol (Homo sapiens)
Mg2+ [extracellular region]
TUSC3 transports Mg2+ from extracellular region to cytosol (Homo sapiens)
Mg2+ [extracellular region]
SLC-mediated transmembrane transport (Homo sapiens)
Transport of bile salts and organic acids, metal ions and amine compounds (Homo sapiens)
Metal ion SLC transporters (Homo sapiens)
SLC41A1,2 transport Mg2+ from extracellular region to cytosol (Homo sapiens)
Mg2+ [extracellular region]
Extracellular matrix organization (Mus musculus)
Integrin cell surface interactions (Mus musculus)
Collagen type I binds integrin alpha11beta1 (Mus musculus)
Mg2+ [extracellular region]
Collagen type I:Mg2+:Integrin alpha 11 beta 1 [plasma membrane] (Mus musculus)
Mg2+ [extracellular region]
Collagen type II binds integrin alpha10beta1 (Mus musculus)
Mg2+ [extracellular region]
Integrin alpha10beta1:Collagen type II fibril:Mg2+ [plasma membrane] (Mus musculus)
Mg2+ [extracellular region]
Interaction of integrin alphaDbeta2 with fibrin (Mus musculus)
Mg2+ [extracellular region]
Integrin alphaDbeta2:fibrin multimer:Mg++ [plasma membrane] (Mus musculus)
Mg2+ [extracellular region]
Hemostasis (Mus musculus)
Platelet activation, signaling and aggregation (Mus musculus)
Platelet Aggregation (Plug Formation) (Mus musculus)
Integrin signaling (Mus musculus)
Autophosphorylation of PTK2 at Y397 (Mus musculus)
Talin:RIAM complex: ECM ligands:Integrin alphaIIb beta3:Active (p-Y419)- SRC:PTK2 [plasma membrane] (Mus musculus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Talin:RIAM complex:ECM ligands: alphaIIb beta3:Active p-Y419-SRC:pY397-PTK2 [plasma membrane] (Mus musculus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Autophosphorylation of SRC (Mus musculus)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:SRC) [plasma membrane] (Mus musculus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Clustering of Integrin alphaIIb beta3 complexes (Mus musculus)
Focal complex [plasma membrane] (Mus musculus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Mus musculus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Dephosphorylation of inactive SRC by PTPB1 (Mus musculus)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:Inactive (p-Y530)-SRC) [plasma membrane] (Mus musculus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:SRC) [plasma membrane] (Mus musculus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
GRB2:SOS provides linkage to MAPK signaling for Integrins (Mus musculus)
Interaction of SOS with GRB2 bound to FADK1 (Mus musculus)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Mus musculus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
GRB2:SOS:p-PTK2:Focal adhesion [plasma membrane] (Mus musculus)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Mus musculus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Recruitment of GRB2 to p-PTK2 (Mus musculus)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Mus musculus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Interaction of integrin alphaIIb beta3 with Fibrinogen (Mus musculus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Focal complex [plasma membrane] (Mus musculus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Phosphorylation of pPTK2 by SRC (Mus musculus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Talin:RIAM complex:ECM ligands: alphaIIb beta3:Active p-Y419-SRC:pY397-PTK2 [plasma membrane] (Mus musculus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Release of CSK from SRC (Mus musculus)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:Inactive (p-Y530)-SRC) [plasma membrane] (Mus musculus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Mus musculus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
SYK activation by SRC (Mus musculus)
Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane] (Mus musculus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Talin:RIAM:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC):p(Y)-SYK [plasma membrane] (Mus musculus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
SYK binds to integrin alphaIIb beta3 (Mus musculus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane] (Mus musculus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Translocation of PTK2 to Focal complexes (Mus musculus)
Talin:RIAM complex: ECM ligands:Integrin alphaIIb beta3:Active (p-Y419)- SRC:PTK2 [plasma membrane] (Mus musculus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
p130Cas linkage to MAPK signaling for integrins (Mus musculus)
Crk binding to p130cas (Mus musculus)
CRK:p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Phosphorylation of BCAR1 by SRC-PTK2 complex (Mus musculus)
BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Recruitment of BCAR1 to PTK2 complex (Mus musculus)
BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Response to elevated platelet cytosolic Ca2+ (Mus musculus)
Platelet degranulation (Mus musculus)
Exocytosis of platelet dense granule content (Mus musculus)
Platelet dense granule content [extracellular region] (Mus musculus)
Mg2+ [extracellular region]
Platelet homeostasis (Mus musculus)
Platelet calcium homeostasis (Mus musculus)
Elevation of cytosolic Ca2+ levels (Mus musculus)
Cation influx mediated by TRPC3/6/7 (Mus musculus)
Cations [extracellular region]
Mg2+ [extracellular region]
Metabolism (Mus musculus)
Metabolism of nucleotides (Mus musculus)
Nucleotide catabolism (Mus musculus)
Phosphate bond hydrolysis by NTPDase proteins (Mus musculus)
NTPDase1 hydrolyzes nucleoside diphosphates (Mus musculus)
NTPDase1:Ca2+,Mg2+ [plasma membrane] (Mus musculus)
Ca2+,Mg2+ [extracellular region]
Mg2+ [extracellular region]
NTPDase1 hydrolyzes nucleoside triphosphates (Mus musculus)
NTPDase1:Ca2+,Mg2+ [plasma membrane] (Mus musculus)
Ca2+,Mg2+ [extracellular region]
Mg2+ [extracellular region]
NTPDase2 hydrolyzes nucleoside triphosphates (Mus musculus)
NTPDase2:Ca2+,Mg2+ [plasma membrane] (Mus musculus)
Ca2+,Mg2+ [extracellular region]
Mg2+ [extracellular region]
NTPDase3 hydrolyzes nucleoside diphosphates (Mus musculus)
NTPDase3:Ca2+,Mg2+ [plasma membrane] (Mus musculus)
Ca2+,Mg2+ [extracellular region]
Mg2+ [extracellular region]
NTPDase3 hydrolyzes nucleoside triphosphates (Mus musculus)
NTPDase3:Ca2+,Mg2+ [plasma membrane] (Mus musculus)
Ca2+,Mg2+ [extracellular region]
Mg2+ [extracellular region]
NTPDase5 hydrolyzes nucleoside diphosphates (Mus musculus)
NPTDase5:Ca2+,Mg2+ [extracellular region] (Mus musculus)
Ca2+,Mg2+ [extracellular region]
Mg2+ [extracellular region]
NTPDase6 hydrolyzes nucleoside diphosphates (Mus musculus)
NTPDase6:Ca2+,Mg2+ [extracellular region] (Mus musculus)
Ca2+,Mg2+ [extracellular region]
Mg2+ [extracellular region]
NTPDase8 hydrolyzes nucleoside diphosphates (Mus musculus)
NTPDase8:Ca2+,Mg2+ [plasma membrane] (Mus musculus)
Ca2+,Mg2+ [extracellular region]
Mg2+ [extracellular region]
NTPDase8 hydrolyzes nucleoside triphosphates (Mus musculus)
NTPDase8:Ca2+,Mg2+ [plasma membrane] (Mus musculus)
Ca2+,Mg2+ [extracellular region]
Mg2+ [extracellular region]
Signal Transduction (Mus musculus)
Integrin signaling (Mus musculus)
Autophosphorylation of PTK2 at Y397 (Mus musculus)
Talin:RIAM complex: ECM ligands:Integrin alphaIIb beta3:Active (p-Y419)- SRC:PTK2 [plasma membrane] (Mus musculus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Talin:RIAM complex:ECM ligands: alphaIIb beta3:Active p-Y419-SRC:pY397-PTK2 [plasma membrane] (Mus musculus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Autophosphorylation of SRC (Mus musculus)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:SRC) [plasma membrane] (Mus musculus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Clustering of Integrin alphaIIb beta3 complexes (Mus musculus)
Focal complex [plasma membrane] (Mus musculus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Mus musculus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Dephosphorylation of inactive SRC by PTPB1 (Mus musculus)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:Inactive (p-Y530)-SRC) [plasma membrane] (Mus musculus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:SRC) [plasma membrane] (Mus musculus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
GRB2:SOS provides linkage to MAPK signaling for Integrins (Mus musculus)
Interaction of SOS with GRB2 bound to FADK1 (Mus musculus)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Mus musculus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
GRB2:SOS:p-PTK2:Focal adhesion [plasma membrane] (Mus musculus)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Mus musculus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Recruitment of GRB2 to p-PTK2 (Mus musculus)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Mus musculus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Interaction of integrin alphaIIb beta3 with Fibrinogen (Mus musculus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Focal complex [plasma membrane] (Mus musculus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Phosphorylation of pPTK2 by SRC (Mus musculus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Talin:RIAM complex:ECM ligands: alphaIIb beta3:Active p-Y419-SRC:pY397-PTK2 [plasma membrane] (Mus musculus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Release of CSK from SRC (Mus musculus)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:Inactive (p-Y530)-SRC) [plasma membrane] (Mus musculus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Mus musculus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
SYK activation by SRC (Mus musculus)
Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane] (Mus musculus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Talin:RIAM:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC):p(Y)-SYK [plasma membrane] (Mus musculus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
SYK binds to integrin alphaIIb beta3 (Mus musculus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane] (Mus musculus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Translocation of PTK2 to Focal complexes (Mus musculus)
Talin:RIAM complex: ECM ligands:Integrin alphaIIb beta3:Active (p-Y419)- SRC:PTK2 [plasma membrane] (Mus musculus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
p130Cas linkage to MAPK signaling for integrins (Mus musculus)
Crk binding to p130cas (Mus musculus)
CRK:p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Phosphorylation of BCAR1 by SRC-PTK2 complex (Mus musculus)
BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Recruitment of BCAR1 to PTK2 complex (Mus musculus)
BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
MAPK family signaling cascades (Mus musculus)
MAPK1/MAPK3 signaling (Mus musculus)
RAF/MAP kinase cascade (Mus musculus)
MAP2K and MAPK activation (Mus musculus)
Dissociation of RAS:RAF complex (Mus musculus)
RAF/MAPK scaffolds [cytosol] (Mus musculus)
Focal Adhesion/Focal contacts [plasma membrane] (Mus musculus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Mus musculus)
Focal complex [plasma membrane] (Mus musculus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Mus musculus)
RAF/MAPK scaffolds [cytosol] (Mus musculus)
Focal Adhesion/Focal contacts [plasma membrane] (Mus musculus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Mus musculus)
Focal complex [plasma membrane] (Mus musculus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Dual mechanism MAP2K inhibitors bind MAP2Ks (Mus musculus)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Mus musculus)
RAF/MAPK scaffolds [cytosol] (Mus musculus)
Focal Adhesion/Focal contacts [plasma membrane] (Mus musculus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Mus musculus)
Focal complex [plasma membrane] (Mus musculus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Mus musculus)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Mus musculus)
RAF/MAPK scaffolds [cytosol] (Mus musculus)
Focal Adhesion/Focal contacts [plasma membrane] (Mus musculus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Mus musculus)
Focal complex [plasma membrane] (Mus musculus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Dual mechanism MAPK inhibitors bind MAPKs (Mus musculus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Mus musculus)
RAF/MAPK scaffolds [cytosol] (Mus musculus)
Focal Adhesion/Focal contacts [plasma membrane] (Mus musculus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Mus musculus)
Focal complex [plasma membrane] (Mus musculus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors [plasma membrane] (Mus musculus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Mus musculus)
RAF/MAPK scaffolds [cytosol] (Mus musculus)
Focal Adhesion/Focal contacts [plasma membrane] (Mus musculus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Mus musculus)
Focal complex [plasma membrane] (Mus musculus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
MAP2Ks and MAPKs bind to the activated RAF complex (Mus musculus)
RAF/MAPK scaffolds [cytosol] (Mus musculus)
Focal Adhesion/Focal contacts [plasma membrane] (Mus musculus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Mus musculus)
Focal complex [plasma membrane] (Mus musculus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Mus musculus)
RAF/MAPK scaffolds [cytosol] (Mus musculus)
Focal Adhesion/Focal contacts [plasma membrane] (Mus musculus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Mus musculus)
Focal complex [plasma membrane] (Mus musculus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
MAP2Ks phosphorylate MAPKs (Mus musculus)
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Mus musculus)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Mus musculus)
RAF/MAPK scaffolds [cytosol] (Mus musculus)
Focal Adhesion/Focal contacts [plasma membrane] (Mus musculus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Mus musculus)
Focal complex [plasma membrane] (Mus musculus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Mus musculus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Mus musculus)
RAF/MAPK scaffolds [cytosol] (Mus musculus)
Focal Adhesion/Focal contacts [plasma membrane] (Mus musculus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Mus musculus)
Focal complex [plasma membrane] (Mus musculus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Mus musculus)
RAF/MAPK scaffolds [cytosol] (Mus musculus)
Focal Adhesion/Focal contacts [plasma membrane] (Mus musculus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Mus musculus)
Focal complex [plasma membrane] (Mus musculus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors [plasma membrane] (Mus musculus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Mus musculus)
RAF/MAPK scaffolds [cytosol] (Mus musculus)
Focal Adhesion/Focal contacts [plasma membrane] (Mus musculus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Mus musculus)
Focal complex [plasma membrane] (Mus musculus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Mus musculus)
RAF/MAPK scaffolds [cytosol] (Mus musculus)
Focal Adhesion/Focal contacts [plasma membrane] (Mus musculus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Mus musculus)
Focal complex [plasma membrane] (Mus musculus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
RAF phosphorylates MAP2K dimer (Mus musculus)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Mus musculus)
RAF/MAPK scaffolds [cytosol] (Mus musculus)
Focal Adhesion/Focal contacts [plasma membrane] (Mus musculus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Mus musculus)
Focal complex [plasma membrane] (Mus musculus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Mus musculus)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Mus musculus)
RAF/MAPK scaffolds [cytosol] (Mus musculus)
Focal Adhesion/Focal contacts [plasma membrane] (Mus musculus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Mus musculus)
Focal complex [plasma membrane] (Mus musculus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Mus musculus)
RAF/MAPK scaffolds [cytosol] (Mus musculus)
Focal Adhesion/Focal contacts [plasma membrane] (Mus musculus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Mus musculus)
Focal complex [plasma membrane] (Mus musculus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks (Mus musculus)
activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Mus musculus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Mus musculus)
RAF/MAPK scaffolds [cytosol] (Mus musculus)
Focal Adhesion/Focal contacts [plasma membrane] (Mus musculus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Mus musculus)
Focal complex [plasma membrane] (Mus musculus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Mus musculus)
RAF/MAPK scaffolds [cytosol] (Mus musculus)
Focal Adhesion/Focal contacts [plasma membrane] (Mus musculus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Mus musculus)
Focal complex [plasma membrane] (Mus musculus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Single mechanism MAPK inhibitors bind phosphorylated MAPK (Mus musculus)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Mus musculus)
RAF/MAPK scaffolds [cytosol] (Mus musculus)
Focal Adhesion/Focal contacts [plasma membrane] (Mus musculus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Mus musculus)
Focal complex [plasma membrane] (Mus musculus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK:single mechanism MAPK inhibitors [plasma membrane] (Mus musculus)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Mus musculus)
RAF/MAPK scaffolds [cytosol] (Mus musculus)
Focal Adhesion/Focal contacts [plasma membrane] (Mus musculus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Mus musculus)
Focal complex [plasma membrane] (Mus musculus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Transport of small molecules (Mus musculus)
Miscellaneous transport and binding events (Mus musculus)
MAGT1 transports Mg2+ from extracellular region to cytosol (Mus musculus)
Mg2+ [extracellular region]
NIPAs transport Mg2+ from extracellular region to cytosol (Mus musculus)
Mg2+ [extracellular region]
TUSC3 transports Mg2+ from extracellular region to cytosol (Mus musculus)
Mg2+ [extracellular region]
SLC-mediated transmembrane transport (Mus musculus)
Transport of bile salts and organic acids, metal ions and amine compounds (Mus musculus)
Metal ion SLC transporters (Mus musculus)
SLC41A1,2 transport Mg2+ from extracellular region to cytosol (Mus musculus)
Mg2+ [extracellular region]
Hemostasis (Plasmodium falciparum)
Platelet activation, signaling and aggregation (Plasmodium falciparum)
Response to elevated platelet cytosolic Ca2+ (Plasmodium falciparum)
Platelet degranulation (Plasmodium falciparum)
Exocytosis of platelet dense granule content (Plasmodium falciparum)
Platelet dense granule content [extracellular region] (Plasmodium falciparum)
Mg2+ [extracellular region]
Metabolism (Plasmodium falciparum)
Metabolism of nucleotides (Plasmodium falciparum)
Nucleotide catabolism (Plasmodium falciparum)
Phosphate bond hydrolysis by NTPDase proteins (Plasmodium falciparum)
NTPDase1 hydrolyzes nucleoside diphosphates (Plasmodium falciparum)
NTPDase1:Ca2+,Mg2+ [plasma membrane] (Plasmodium falciparum)
Ca2+,Mg2+ [extracellular region]
Mg2+ [extracellular region]
NTPDase1 hydrolyzes nucleoside triphosphates (Plasmodium falciparum)
NTPDase1:Ca2+,Mg2+ [plasma membrane] (Plasmodium falciparum)
Ca2+,Mg2+ [extracellular region]
Mg2+ [extracellular region]
NTPDase2 hydrolyzes nucleoside triphosphates (Plasmodium falciparum)
NTPDase2:Ca2+,Mg2+ [plasma membrane] (Plasmodium falciparum)
Ca2+,Mg2+ [extracellular region]
Mg2+ [extracellular region]
NTPDase3 hydrolyzes nucleoside diphosphates (Plasmodium falciparum)
NTPDase3:Ca2+,Mg2+ [plasma membrane] (Plasmodium falciparum)
Ca2+,Mg2+ [extracellular region]
Mg2+ [extracellular region]
NTPDase3 hydrolyzes nucleoside triphosphates (Plasmodium falciparum)
NTPDase3:Ca2+,Mg2+ [plasma membrane] (Plasmodium falciparum)
Ca2+,Mg2+ [extracellular region]
Mg2+ [extracellular region]
NTPDase5 hydrolyzes nucleoside diphosphates (Plasmodium falciparum)
NPTDase5:Ca2+,Mg2+ [extracellular region] (Plasmodium falciparum)
Ca2+,Mg2+ [extracellular region]
Mg2+ [extracellular region]
NTPDase6 hydrolyzes nucleoside diphosphates (Plasmodium falciparum)
NTPDase6:Ca2+,Mg2+ [extracellular region] (Plasmodium falciparum)
Ca2+,Mg2+ [extracellular region]
Mg2+ [extracellular region]
NTPDase8 hydrolyzes nucleoside diphosphates (Plasmodium falciparum)
NTPDase2:Ca2+,Mg2+ [plasma membrane] (Plasmodium falciparum)
Ca2+,Mg2+ [extracellular region]
Mg2+ [extracellular region]
NTPDase8 hydrolyzes nucleoside triphosphates (Plasmodium falciparum)
NTPDase2:Ca2+,Mg2+ [plasma membrane] (Plasmodium falciparum)
Ca2+,Mg2+ [extracellular region]
Mg2+ [extracellular region]
Transport of small molecules (Plasmodium falciparum)
Miscellaneous transport and binding events (Plasmodium falciparum)
MAGT1 transports Mg2+ from extracellular region to cytosol (Plasmodium falciparum)
Mg2+ [extracellular region]
TUSC3 transports Mg2+ from extracellular region to cytosol (Plasmodium falciparum)
Mg2+ [extracellular region]
Extracellular matrix organization (Rattus norvegicus)
Integrin cell surface interactions (Rattus norvegicus)
Collagen type I binds integrin alpha11beta1 (Rattus norvegicus)
Mg2+ [extracellular region]
Collagen type I:Mg2+:Integrin alpha 11 beta 1 [plasma membrane] (Rattus norvegicus)
Mg2+ [extracellular region]
Collagen type II binds integrin alpha10beta1 (Rattus norvegicus)
Mg2+ [extracellular region]
Integrin alpha10beta1:Collagen type II fibril:Mg2+ [plasma membrane] (Rattus norvegicus)
Mg2+ [extracellular region]
Interaction of integrin alphaDbeta2 with fibrin (Rattus norvegicus)
Mg2+ [extracellular region]
Integrin alphaDbeta2:fibrin multimer:Mg++ [plasma membrane] (Rattus norvegicus)
Mg2+ [extracellular region]
Hemostasis (Rattus norvegicus)
Platelet activation, signaling and aggregation (Rattus norvegicus)
Platelet Aggregation (Plug Formation) (Rattus norvegicus)
Integrin signaling (Rattus norvegicus)
Autophosphorylation of PTK2 at Y397 (Rattus norvegicus)
Talin:RIAM complex: ECM ligands:Integrin alphaIIb beta3:Active (p-Y419)- SRC:PTK2 [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Rattus norvegicus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Talin:RIAM complex:ECM ligands: alphaIIb beta3:Active p-Y419-SRC:pY397-PTK2 [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Rattus norvegicus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Autophosphorylation of SRC (Rattus norvegicus)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:SRC) [plasma membrane] (Rattus norvegicus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Rattus norvegicus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Clustering of Integrin alphaIIb beta3 complexes (Rattus norvegicus)
Focal complex [plasma membrane] (Rattus norvegicus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Rattus norvegicus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Dephosphorylation of inactive SRC by PTPB1 (Rattus norvegicus)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:Inactive (p-Y530)-SRC) [plasma membrane] (Rattus norvegicus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:SRC) [plasma membrane] (Rattus norvegicus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
GRB2:SOS provides linkage to MAPK signaling for Integrins (Rattus norvegicus)
Interaction of SOS with GRB2 bound to FADK1 (Rattus norvegicus)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Rattus norvegicus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
GRB2:SOS:p-PTK2:Focal adhesion [plasma membrane] (Rattus norvegicus)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Rattus norvegicus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Recruitment of GRB2 to p-PTK2 (Rattus norvegicus)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Rattus norvegicus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Rattus norvegicus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Interaction of integrin alphaIIb beta3 with Fibrinogen (Rattus norvegicus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Focal complex [plasma membrane] (Rattus norvegicus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Phosphorylation of pPTK2 by SRC (Rattus norvegicus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Rattus norvegicus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Talin:RIAM complex:ECM ligands: alphaIIb beta3:Active p-Y419-SRC:pY397-PTK2 [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Rattus norvegicus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Release of CSK from SRC (Rattus norvegicus)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:Inactive (p-Y530)-SRC) [plasma membrane] (Rattus norvegicus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Rattus norvegicus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
SYK activation by SRC (Rattus norvegicus)
Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Rattus norvegicus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Talin:RIAM:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC):p(Y)-SYK [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Rattus norvegicus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
SYK binds to integrin alphaIIb beta3 (Rattus norvegicus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Rattus norvegicus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Rattus norvegicus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Translocation of PTK2 to Focal complexes (Rattus norvegicus)
Talin:RIAM complex: ECM ligands:Integrin alphaIIb beta3:Active (p-Y419)- SRC:PTK2 [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Rattus norvegicus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Rattus norvegicus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
p130Cas linkage to MAPK signaling for integrins (Rattus norvegicus)
Crk binding to p130cas (Rattus norvegicus)
CRK:p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Rattus norvegicus)
p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Rattus norvegicus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Rattus norvegicus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Phosphorylation of BCAR1 by SRC-PTK2 complex (Rattus norvegicus)
BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Rattus norvegicus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Rattus norvegicus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Recruitment of BCAR1 to PTK2 complex (Rattus norvegicus)
BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Rattus norvegicus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Rattus norvegicus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Response to elevated platelet cytosolic Ca2+ (Rattus norvegicus)
Platelet degranulation (Rattus norvegicus)
Exocytosis of platelet dense granule content (Rattus norvegicus)
Platelet dense granule content [extracellular region] (Rattus norvegicus)
Mg2+ [extracellular region]
Platelet homeostasis (Rattus norvegicus)
Platelet calcium homeostasis (Rattus norvegicus)
Elevation of cytosolic Ca2+ levels (Rattus norvegicus)
Cation influx mediated by TRPC3/6/7 (Rattus norvegicus)
Cations [extracellular region]
Mg2+ [extracellular region]
Metabolism (Rattus norvegicus)
Metabolism of nucleotides (Rattus norvegicus)
Nucleotide catabolism (Rattus norvegicus)
Phosphate bond hydrolysis by NTPDase proteins (Rattus norvegicus)
NTPDase1 hydrolyzes nucleoside diphosphates (Rattus norvegicus)
NTPDase1:Ca2+,Mg2+ [plasma membrane] (Rattus norvegicus)
Ca2+,Mg2+ [extracellular region]
Mg2+ [extracellular region]
NTPDase1 hydrolyzes nucleoside triphosphates (Rattus norvegicus)
NTPDase1:Ca2+,Mg2+ [plasma membrane] (Rattus norvegicus)
Ca2+,Mg2+ [extracellular region]
Mg2+ [extracellular region]
NTPDase2 hydrolyzes nucleoside triphosphates (Rattus norvegicus)
NTPDase2:Ca2+,Mg2+ [plasma membrane] (Rattus norvegicus)
Ca2+,Mg2+ [extracellular region]
Mg2+ [extracellular region]
NTPDase3 hydrolyzes nucleoside diphosphates (Rattus norvegicus)
NTPDase3:Ca2+,Mg2+ [plasma membrane] (Rattus norvegicus)
Ca2+,Mg2+ [extracellular region]
Mg2+ [extracellular region]
NTPDase3 hydrolyzes nucleoside triphosphates (Rattus norvegicus)
NTPDase3:Ca2+,Mg2+ [plasma membrane] (Rattus norvegicus)
Ca2+,Mg2+ [extracellular region]
Mg2+ [extracellular region]
NTPDase5 hydrolyzes nucleoside diphosphates (Rattus norvegicus)
NPTDase5:Ca2+,Mg2+ [extracellular region] (Rattus norvegicus)
Ca2+,Mg2+ [extracellular region]
Mg2+ [extracellular region]
NTPDase6 hydrolyzes nucleoside diphosphates (Rattus norvegicus)
NTPDase6:Ca2+,Mg2+ [extracellular region] (Rattus norvegicus)
Ca2+,Mg2+ [extracellular region]
Mg2+ [extracellular region]
NTPDase8 hydrolyzes nucleoside diphosphates (Rattus norvegicus)
NTPDase8:Ca2+,Mg2+ [plasma membrane] (Rattus norvegicus)
Ca2+,Mg2+ [extracellular region]
Mg2+ [extracellular region]
NTPDase8 hydrolyzes nucleoside triphosphates (Rattus norvegicus)
NTPDase8:Ca2+,Mg2+ [plasma membrane] (Rattus norvegicus)
Ca2+,Mg2+ [extracellular region]
Mg2+ [extracellular region]
Signal Transduction (Rattus norvegicus)
Integrin signaling (Rattus norvegicus)
Autophosphorylation of PTK2 at Y397 (Rattus norvegicus)
Talin:RIAM complex: ECM ligands:Integrin alphaIIb beta3:Active (p-Y419)- SRC:PTK2 [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Rattus norvegicus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Talin:RIAM complex:ECM ligands: alphaIIb beta3:Active p-Y419-SRC:pY397-PTK2 [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Rattus norvegicus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Autophosphorylation of SRC (Rattus norvegicus)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:SRC) [plasma membrane] (Rattus norvegicus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Rattus norvegicus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Clustering of Integrin alphaIIb beta3 complexes (Rattus norvegicus)
Focal complex [plasma membrane] (Rattus norvegicus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Rattus norvegicus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Dephosphorylation of inactive SRC by PTPB1 (Rattus norvegicus)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:Inactive (p-Y530)-SRC) [plasma membrane] (Rattus norvegicus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:SRC) [plasma membrane] (Rattus norvegicus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
GRB2:SOS provides linkage to MAPK signaling for Integrins (Rattus norvegicus)
Interaction of SOS with GRB2 bound to FADK1 (Rattus norvegicus)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Rattus norvegicus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
GRB2:SOS:p-PTK2:Focal adhesion [plasma membrane] (Rattus norvegicus)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Rattus norvegicus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Recruitment of GRB2 to p-PTK2 (Rattus norvegicus)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Rattus norvegicus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Rattus norvegicus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Interaction of integrin alphaIIb beta3 with Fibrinogen (Rattus norvegicus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Focal complex [plasma membrane] (Rattus norvegicus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Phosphorylation of pPTK2 by SRC (Rattus norvegicus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Rattus norvegicus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Talin:RIAM complex:ECM ligands: alphaIIb beta3:Active p-Y419-SRC:pY397-PTK2 [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Rattus norvegicus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Release of CSK from SRC (Rattus norvegicus)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:Inactive (p-Y530)-SRC) [plasma membrane] (Rattus norvegicus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Rattus norvegicus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
SYK activation by SRC (Rattus norvegicus)
Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Rattus norvegicus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Talin:RIAM:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC):p(Y)-SYK [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Rattus norvegicus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
SYK binds to integrin alphaIIb beta3 (Rattus norvegicus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Rattus norvegicus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Rattus norvegicus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Translocation of PTK2 to Focal complexes (Rattus norvegicus)
Talin:RIAM complex: ECM ligands:Integrin alphaIIb beta3:Active (p-Y419)- SRC:PTK2 [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Rattus norvegicus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Rattus norvegicus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
p130Cas linkage to MAPK signaling for integrins (Rattus norvegicus)
Crk binding to p130cas (Rattus norvegicus)
CRK:p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Rattus norvegicus)
p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Rattus norvegicus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Rattus norvegicus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Phosphorylation of BCAR1 by SRC-PTK2 complex (Rattus norvegicus)
BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Rattus norvegicus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Rattus norvegicus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Recruitment of BCAR1 to PTK2 complex (Rattus norvegicus)
BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Rattus norvegicus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Rattus norvegicus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
MAPK family signaling cascades (Rattus norvegicus)
MAPK1/MAPK3 signaling (Rattus norvegicus)
RAF/MAP kinase cascade (Rattus norvegicus)
MAP2K and MAPK activation (Rattus norvegicus)
Dissociation of RAS:RAF complex (Rattus norvegicus)
RAF/MAPK scaffolds [cytosol] (Rattus norvegicus)
Focal Adhesion/Focal contacts [plasma membrane] (Rattus norvegicus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Rattus norvegicus)
Focal complex [plasma membrane] (Rattus norvegicus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Rattus norvegicus)
RAF/MAPK scaffolds [cytosol] (Rattus norvegicus)
Focal Adhesion/Focal contacts [plasma membrane] (Rattus norvegicus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Rattus norvegicus)
Focal complex [plasma membrane] (Rattus norvegicus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Dual mechanism MAP2K inhibitors bind MAP2Ks (Rattus norvegicus)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Rattus norvegicus)
RAF/MAPK scaffolds [cytosol] (Rattus norvegicus)
Focal Adhesion/Focal contacts [plasma membrane] (Rattus norvegicus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Rattus norvegicus)
Focal complex [plasma membrane] (Rattus norvegicus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Rattus norvegicus)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Rattus norvegicus)
RAF/MAPK scaffolds [cytosol] (Rattus norvegicus)
Focal Adhesion/Focal contacts [plasma membrane] (Rattus norvegicus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Rattus norvegicus)
Focal complex [plasma membrane] (Rattus norvegicus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Dual mechanism MAPK inhibitors bind MAPKs (Rattus norvegicus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Rattus norvegicus)
RAF/MAPK scaffolds [cytosol] (Rattus norvegicus)
Focal Adhesion/Focal contacts [plasma membrane] (Rattus norvegicus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Rattus norvegicus)
Focal complex [plasma membrane] (Rattus norvegicus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors [plasma membrane] (Rattus norvegicus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Rattus norvegicus)
RAF/MAPK scaffolds [cytosol] (Rattus norvegicus)
Focal Adhesion/Focal contacts [plasma membrane] (Rattus norvegicus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Rattus norvegicus)
Focal complex [plasma membrane] (Rattus norvegicus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
MAP2Ks and MAPKs bind to the activated RAF complex (Rattus norvegicus)
RAF/MAPK scaffolds [cytosol] (Rattus norvegicus)
Focal Adhesion/Focal contacts [plasma membrane] (Rattus norvegicus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Rattus norvegicus)
Focal complex [plasma membrane] (Rattus norvegicus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Rattus norvegicus)
RAF/MAPK scaffolds [cytosol] (Rattus norvegicus)
Focal Adhesion/Focal contacts [plasma membrane] (Rattus norvegicus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Rattus norvegicus)
Focal complex [plasma membrane] (Rattus norvegicus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
MAP2Ks phosphorylate MAPKs (Rattus norvegicus)
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Rattus norvegicus)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Rattus norvegicus)
RAF/MAPK scaffolds [cytosol] (Rattus norvegicus)
Focal Adhesion/Focal contacts [plasma membrane] (Rattus norvegicus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Rattus norvegicus)
Focal complex [plasma membrane] (Rattus norvegicus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Rattus norvegicus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Rattus norvegicus)
RAF/MAPK scaffolds [cytosol] (Rattus norvegicus)
Focal Adhesion/Focal contacts [plasma membrane] (Rattus norvegicus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Rattus norvegicus)
Focal complex [plasma membrane] (Rattus norvegicus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Rattus norvegicus)
RAF/MAPK scaffolds [cytosol] (Rattus norvegicus)
Focal Adhesion/Focal contacts [plasma membrane] (Rattus norvegicus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Rattus norvegicus)
Focal complex [plasma membrane] (Rattus norvegicus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors [plasma membrane] (Rattus norvegicus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Rattus norvegicus)
RAF/MAPK scaffolds [cytosol] (Rattus norvegicus)
Focal Adhesion/Focal contacts [plasma membrane] (Rattus norvegicus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Rattus norvegicus)
Focal complex [plasma membrane] (Rattus norvegicus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Rattus norvegicus)
RAF/MAPK scaffolds [cytosol] (Rattus norvegicus)
Focal Adhesion/Focal contacts [plasma membrane] (Rattus norvegicus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Rattus norvegicus)
Focal complex [plasma membrane] (Rattus norvegicus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
RAF phosphorylates MAP2K dimer (Rattus norvegicus)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Rattus norvegicus)
RAF/MAPK scaffolds [cytosol] (Rattus norvegicus)
Focal Adhesion/Focal contacts [plasma membrane] (Rattus norvegicus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Rattus norvegicus)
Focal complex [plasma membrane] (Rattus norvegicus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Rattus norvegicus)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Rattus norvegicus)
RAF/MAPK scaffolds [cytosol] (Rattus norvegicus)
Focal Adhesion/Focal contacts [plasma membrane] (Rattus norvegicus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Rattus norvegicus)
Focal complex [plasma membrane] (Rattus norvegicus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Rattus norvegicus)
RAF/MAPK scaffolds [cytosol] (Rattus norvegicus)
Focal Adhesion/Focal contacts [plasma membrane] (Rattus norvegicus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Rattus norvegicus)
Focal complex [plasma membrane] (Rattus norvegicus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks (Rattus norvegicus)
activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Rattus norvegicus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Rattus norvegicus)
RAF/MAPK scaffolds [cytosol] (Rattus norvegicus)
Focal Adhesion/Focal contacts [plasma membrane] (Rattus norvegicus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Rattus norvegicus)
Focal complex [plasma membrane] (Rattus norvegicus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Rattus norvegicus)
RAF/MAPK scaffolds [cytosol] (Rattus norvegicus)
Focal Adhesion/Focal contacts [plasma membrane] (Rattus norvegicus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Rattus norvegicus)
Focal complex [plasma membrane] (Rattus norvegicus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Single mechanism MAPK inhibitors bind phosphorylated MAPK (Rattus norvegicus)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Rattus norvegicus)
RAF/MAPK scaffolds [cytosol] (Rattus norvegicus)
Focal Adhesion/Focal contacts [plasma membrane] (Rattus norvegicus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Rattus norvegicus)
Focal complex [plasma membrane] (Rattus norvegicus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK:single mechanism MAPK inhibitors [plasma membrane] (Rattus norvegicus)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Rattus norvegicus)
RAF/MAPK scaffolds [cytosol] (Rattus norvegicus)
Focal Adhesion/Focal contacts [plasma membrane] (Rattus norvegicus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Rattus norvegicus)
Focal complex [plasma membrane] (Rattus norvegicus)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Transport of small molecules (Rattus norvegicus)
Miscellaneous transport and binding events (Rattus norvegicus)
MAGT1 transports Mg2+ from extracellular region to cytosol (Rattus norvegicus)
Mg2+ [extracellular region]
NIPAs transport Mg2+ from extracellular region to cytosol (Rattus norvegicus)
Mg2+ [extracellular region]
TUSC3 transports Mg2+ from extracellular region to cytosol (Rattus norvegicus)
Mg2+ [extracellular region]
SLC-mediated transmembrane transport (Rattus norvegicus)
Transport of bile salts and organic acids, metal ions and amine compounds (Rattus norvegicus)
Metal ion SLC transporters (Rattus norvegicus)
SLC41A1,2 transport Mg2+ from extracellular region to cytosol (Rattus norvegicus)
Mg2+ [extracellular region]
Hemostasis (Saccharomyces cerevisiae)
Platelet activation, signaling and aggregation (Saccharomyces cerevisiae)
Response to elevated platelet cytosolic Ca2+ (Saccharomyces cerevisiae)
Platelet degranulation (Saccharomyces cerevisiae)
Exocytosis of platelet dense granule content (Saccharomyces cerevisiae)
Platelet dense granule content [extracellular region] (Saccharomyces cerevisiae)
Mg2+ [extracellular region]
Metabolism (Saccharomyces cerevisiae)
Metabolism of nucleotides (Saccharomyces cerevisiae)
Nucleotide catabolism (Saccharomyces cerevisiae)
Phosphate bond hydrolysis by NTPDase proteins (Saccharomyces cerevisiae)
NTPDase5 hydrolyzes nucleoside diphosphates (Saccharomyces cerevisiae)
NPTDase5:Ca2+,Mg2+ [extracellular region] (Saccharomyces cerevisiae)
Ca2+,Mg2+ [extracellular region]
Mg2+ [extracellular region]
NTPDase6 hydrolyzes nucleoside diphosphates (Saccharomyces cerevisiae)
NTPDase6:Ca2+,Mg2+ [extracellular region] (Saccharomyces cerevisiae)
Ca2+,Mg2+ [extracellular region]
Mg2+ [extracellular region]
Transport of small molecules (Saccharomyces cerevisiae)
Miscellaneous transport and binding events (Saccharomyces cerevisiae)
MAGT1 transports Mg2+ from extracellular region to cytosol (Saccharomyces cerevisiae)
Mg2+ [extracellular region]
TUSC3 transports Mg2+ from extracellular region to cytosol (Saccharomyces cerevisiae)
Mg2+ [extracellular region]
Hemostasis (Schizosaccharomyces pombe)
Platelet activation, signaling and aggregation (Schizosaccharomyces pombe)
Response to elevated platelet cytosolic Ca2+ (Schizosaccharomyces pombe)
Platelet degranulation (Schizosaccharomyces pombe)
Exocytosis of platelet dense granule content (Schizosaccharomyces pombe)
Platelet dense granule content [extracellular region] (Schizosaccharomyces pombe)
Mg2+ [extracellular region]
Metabolism (Schizosaccharomyces pombe)
Metabolism of nucleotides (Schizosaccharomyces pombe)
Nucleotide catabolism (Schizosaccharomyces pombe)
Phosphate bond hydrolysis by NTPDase proteins (Schizosaccharomyces pombe)
NTPDase5 hydrolyzes nucleoside diphosphates (Schizosaccharomyces pombe)
NPTDase5:Ca2+,Mg2+ [extracellular region] (Schizosaccharomyces pombe)
Ca2+,Mg2+ [extracellular region]
Mg2+ [extracellular region]
NTPDase6 hydrolyzes nucleoside diphosphates (Schizosaccharomyces pombe)
NTPDase6:Ca2+,Mg2+ [extracellular region] (Schizosaccharomyces pombe)
Ca2+,Mg2+ [extracellular region]
Mg2+ [extracellular region]
Transport of small molecules (Schizosaccharomyces pombe)
Miscellaneous transport and binding events (Schizosaccharomyces pombe)
MAGT1 transports Mg2+ from extracellular region to cytosol (Schizosaccharomyces pombe)
Mg2+ [extracellular region]
TUSC3 transports Mg2+ from extracellular region to cytosol (Schizosaccharomyces pombe)
Mg2+ [extracellular region]
Extracellular matrix organization (Sus scrofa)
Integrin cell surface interactions (Sus scrofa)
Collagen type I binds integrin alpha11beta1 (Sus scrofa)
Mg2+ [extracellular region]
Collagen type I:Mg2+:Integrin alpha 11 beta 1 [plasma membrane] (Sus scrofa)
Mg2+ [extracellular region]
Collagen type II binds integrin alpha10beta1 (Sus scrofa)
Mg2+ [extracellular region]
Integrin alpha10beta1:Collagen type II fibril:Mg2+ [plasma membrane] (Sus scrofa)
Mg2+ [extracellular region]
Interaction of integrin alphaDbeta2 with fibrin (Sus scrofa)
Mg2+ [extracellular region]
Integrin alphaDbeta2:fibrin multimer:Mg++ [plasma membrane] (Sus scrofa)
Mg2+ [extracellular region]
Hemostasis (Sus scrofa)
Platelet activation, signaling and aggregation (Sus scrofa)
Platelet Aggregation (Plug Formation) (Sus scrofa)
Integrin signaling (Sus scrofa)
Autophosphorylation of PTK2 at Y397 (Sus scrofa)
Talin:RIAM complex: ECM ligands:Integrin alphaIIb beta3:Active (p-Y419)- SRC:PTK2 [plasma membrane] (Sus scrofa)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Sus scrofa)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Talin:RIAM complex:ECM ligands: alphaIIb beta3:Active p-Y419-SRC:pY397-PTK2 [plasma membrane] (Sus scrofa)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Sus scrofa)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Autophosphorylation of SRC (Sus scrofa)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:SRC) [plasma membrane] (Sus scrofa)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Sus scrofa)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Clustering of Integrin alphaIIb beta3 complexes (Sus scrofa)
Focal complex [plasma membrane] (Sus scrofa)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Sus scrofa)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Dephosphorylation of inactive SRC by PTPB1 (Sus scrofa)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:Inactive (p-Y530)-SRC) [plasma membrane] (Sus scrofa)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:SRC) [plasma membrane] (Sus scrofa)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
GRB2:SOS provides linkage to MAPK signaling for Integrins (Sus scrofa)
Interaction of SOS with GRB2 bound to FADK1 (Sus scrofa)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Sus scrofa)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Sus scrofa)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Sus scrofa)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
GRB2:SOS:p-PTK2:Focal adhesion [plasma membrane] (Sus scrofa)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Sus scrofa)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Sus scrofa)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Sus scrofa)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Recruitment of GRB2 to p-PTK2 (Sus scrofa)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Sus scrofa)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Sus scrofa)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Sus scrofa)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Sus scrofa)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Sus scrofa)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Interaction of integrin alphaIIb beta3 with Fibrinogen (Sus scrofa)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Focal complex [plasma membrane] (Sus scrofa)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Phosphorylation of pPTK2 by SRC (Sus scrofa)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Sus scrofa)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Sus scrofa)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Talin:RIAM complex:ECM ligands: alphaIIb beta3:Active p-Y419-SRC:pY397-PTK2 [plasma membrane] (Sus scrofa)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Sus scrofa)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Release of CSK from SRC (Sus scrofa)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:Inactive (p-Y530)-SRC) [plasma membrane] (Sus scrofa)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Sus scrofa)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
SYK activation by SRC (Sus scrofa)
Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane] (Sus scrofa)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Sus scrofa)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Talin:RIAM:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC):p(Y)-SYK [plasma membrane] (Sus scrofa)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Sus scrofa)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
SYK binds to integrin alphaIIb beta3 (Sus scrofa)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Sus scrofa)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane] (Sus scrofa)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Sus scrofa)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
p130Cas linkage to MAPK signaling for integrins (Sus scrofa)
Crk binding to p130cas (Sus scrofa)
CRK:p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Sus scrofa)
p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Sus scrofa)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Sus scrofa)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Sus scrofa)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Sus scrofa)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Sus scrofa)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Sus scrofa)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Phosphorylation of BCAR1 by SRC-PTK2 complex (Sus scrofa)
BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Sus scrofa)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Sus scrofa)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Sus scrofa)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Sus scrofa)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Sus scrofa)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Sus scrofa)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Recruitment of BCAR1 to PTK2 complex (Sus scrofa)
BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Sus scrofa)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Sus scrofa)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Sus scrofa)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Sus scrofa)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Sus scrofa)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Response to elevated platelet cytosolic Ca2+ (Sus scrofa)
Platelet degranulation (Sus scrofa)
Exocytosis of platelet dense granule content (Sus scrofa)
Platelet dense granule content [extracellular region] (Sus scrofa)
Mg2+ [extracellular region]
Platelet homeostasis (Sus scrofa)
Platelet calcium homeostasis (Sus scrofa)
Elevation of cytosolic Ca2+ levels (Sus scrofa)
Cation influx mediated by TRPC3/6/7 (Sus scrofa)
Cations [extracellular region]
Mg2+ [extracellular region]
Metabolism (Sus scrofa)
Metabolism of nucleotides (Sus scrofa)
Nucleotide catabolism (Sus scrofa)
Phosphate bond hydrolysis by NTPDase proteins (Sus scrofa)
NTPDase1 hydrolyzes nucleoside diphosphates (Sus scrofa)
NTPDase1:Ca2+,Mg2+ [plasma membrane] (Sus scrofa)
Ca2+,Mg2+ [extracellular region]
Mg2+ [extracellular region]
NTPDase1 hydrolyzes nucleoside triphosphates (Sus scrofa)
NTPDase1:Ca2+,Mg2+ [plasma membrane] (Sus scrofa)
Ca2+,Mg2+ [extracellular region]
Mg2+ [extracellular region]
NTPDase2 hydrolyzes nucleoside triphosphates (Sus scrofa)
NTPDase2:Ca2+,Mg2+ [plasma membrane] (Sus scrofa)
Ca2+,Mg2+ [extracellular region]
Mg2+ [extracellular region]
NTPDase3 hydrolyzes nucleoside diphosphates (Sus scrofa)
NTPDase3:Ca2+,Mg2+ [plasma membrane] (Sus scrofa)
Ca2+,Mg2+ [extracellular region]
Mg2+ [extracellular region]
NTPDase3 hydrolyzes nucleoside triphosphates (Sus scrofa)
NTPDase3:Ca2+,Mg2+ [plasma membrane] (Sus scrofa)
Ca2+,Mg2+ [extracellular region]
Mg2+ [extracellular region]
NTPDase5 hydrolyzes nucleoside diphosphates (Sus scrofa)
NPTDase5:Ca2+,Mg2+ [extracellular region] (Sus scrofa)
Ca2+,Mg2+ [extracellular region]
Mg2+ [extracellular region]
NTPDase6 hydrolyzes nucleoside diphosphates (Sus scrofa)
NTPDase6:Ca2+,Mg2+ [extracellular region] (Sus scrofa)
Ca2+,Mg2+ [extracellular region]
Mg2+ [extracellular region]
NTPDase8 hydrolyzes nucleoside diphosphates (Sus scrofa)
NTPDase8:Ca2+,Mg2+ [plasma membrane] (Sus scrofa)
Ca2+,Mg2+ [extracellular region]
Mg2+ [extracellular region]
NTPDase8 hydrolyzes nucleoside triphosphates (Sus scrofa)
NTPDase8:Ca2+,Mg2+ [plasma membrane] (Sus scrofa)
Ca2+,Mg2+ [extracellular region]
Mg2+ [extracellular region]
Signal Transduction (Sus scrofa)
Integrin signaling (Sus scrofa)
Autophosphorylation of PTK2 at Y397 (Sus scrofa)
Talin:RIAM complex: ECM ligands:Integrin alphaIIb beta3:Active (p-Y419)- SRC:PTK2 [plasma membrane] (Sus scrofa)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Sus scrofa)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Talin:RIAM complex:ECM ligands: alphaIIb beta3:Active p-Y419-SRC:pY397-PTK2 [plasma membrane] (Sus scrofa)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Sus scrofa)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Autophosphorylation of SRC (Sus scrofa)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:SRC) [plasma membrane] (Sus scrofa)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Sus scrofa)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Clustering of Integrin alphaIIb beta3 complexes (Sus scrofa)
Focal complex [plasma membrane] (Sus scrofa)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Sus scrofa)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Dephosphorylation of inactive SRC by PTPB1 (Sus scrofa)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:Inactive (p-Y530)-SRC) [plasma membrane] (Sus scrofa)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:SRC) [plasma membrane] (Sus scrofa)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
GRB2:SOS provides linkage to MAPK signaling for Integrins (Sus scrofa)
Interaction of SOS with GRB2 bound to FADK1 (Sus scrofa)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Sus scrofa)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Sus scrofa)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Sus scrofa)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
GRB2:SOS:p-PTK2:Focal adhesion [plasma membrane] (Sus scrofa)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Sus scrofa)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Sus scrofa)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Sus scrofa)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Recruitment of GRB2 to p-PTK2 (Sus scrofa)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Sus scrofa)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Sus scrofa)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Sus scrofa)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Sus scrofa)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Sus scrofa)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Interaction of integrin alphaIIb beta3 with Fibrinogen (Sus scrofa)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Focal complex [plasma membrane] (Sus scrofa)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Phosphorylation of pPTK2 by SRC (Sus scrofa)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Sus scrofa)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Sus scrofa)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Talin:RIAM complex:ECM ligands: alphaIIb beta3:Active p-Y419-SRC:pY397-PTK2 [plasma membrane] (Sus scrofa)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Sus scrofa)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Release of CSK from SRC (Sus scrofa)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:Inactive (p-Y530)-SRC) [plasma membrane] (Sus scrofa)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Sus scrofa)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
SYK activation by SRC (Sus scrofa)
Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane] (Sus scrofa)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Sus scrofa)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Talin:RIAM:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC):p(Y)-SYK [plasma membrane] (Sus scrofa)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Sus scrofa)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
SYK binds to integrin alphaIIb beta3 (Sus scrofa)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Sus scrofa)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane] (Sus scrofa)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Sus scrofa)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
p130Cas linkage to MAPK signaling for integrins (Sus scrofa)
Crk binding to p130cas (Sus scrofa)
CRK:p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Sus scrofa)
p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Sus scrofa)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Sus scrofa)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Sus scrofa)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Sus scrofa)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Sus scrofa)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Sus scrofa)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Phosphorylation of BCAR1 by SRC-PTK2 complex (Sus scrofa)
BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Sus scrofa)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Sus scrofa)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Sus scrofa)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Sus scrofa)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Sus scrofa)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Sus scrofa)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Recruitment of BCAR1 to PTK2 complex (Sus scrofa)
BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Sus scrofa)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Sus scrofa)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Sus scrofa)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Sus scrofa)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Sus scrofa)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
MAPK family signaling cascades (Sus scrofa)
MAPK1/MAPK3 signaling (Sus scrofa)
RAF/MAP kinase cascade (Sus scrofa)
MAP2K and MAPK activation (Sus scrofa)
Dissociation of RAS:RAF complex (Sus scrofa)
RAF/MAPK scaffolds [cytosol] (Sus scrofa)
Focal Adhesion/Focal contacts [plasma membrane] (Sus scrofa)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Sus scrofa)
Focal complex [plasma membrane] (Sus scrofa)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Sus scrofa)
RAF/MAPK scaffolds [cytosol] (Sus scrofa)
Focal Adhesion/Focal contacts [plasma membrane] (Sus scrofa)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Sus scrofa)
Focal complex [plasma membrane] (Sus scrofa)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Dual mechanism MAP2K inhibitors bind MAP2Ks (Sus scrofa)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Sus scrofa)
RAF/MAPK scaffolds [cytosol] (Sus scrofa)
Focal Adhesion/Focal contacts [plasma membrane] (Sus scrofa)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Sus scrofa)
Focal complex [plasma membrane] (Sus scrofa)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Sus scrofa)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Sus scrofa)
RAF/MAPK scaffolds [cytosol] (Sus scrofa)
Focal Adhesion/Focal contacts [plasma membrane] (Sus scrofa)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Sus scrofa)
Focal complex [plasma membrane] (Sus scrofa)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Dual mechanism MAPK inhibitors bind MAPKs (Sus scrofa)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Sus scrofa)
RAF/MAPK scaffolds [cytosol] (Sus scrofa)
Focal Adhesion/Focal contacts [plasma membrane] (Sus scrofa)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Sus scrofa)
Focal complex [plasma membrane] (Sus scrofa)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors [plasma membrane] (Sus scrofa)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Sus scrofa)
RAF/MAPK scaffolds [cytosol] (Sus scrofa)
Focal Adhesion/Focal contacts [plasma membrane] (Sus scrofa)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Sus scrofa)
Focal complex [plasma membrane] (Sus scrofa)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
MAP2Ks and MAPKs bind to the activated RAF complex (Sus scrofa)
RAF/MAPK scaffolds [cytosol] (Sus scrofa)
Focal Adhesion/Focal contacts [plasma membrane] (Sus scrofa)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Sus scrofa)
Focal complex [plasma membrane] (Sus scrofa)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Sus scrofa)
RAF/MAPK scaffolds [cytosol] (Sus scrofa)
Focal Adhesion/Focal contacts [plasma membrane] (Sus scrofa)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Sus scrofa)
Focal complex [plasma membrane] (Sus scrofa)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
MAP2Ks phosphorylate MAPKs (Sus scrofa)
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Sus scrofa)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Sus scrofa)
RAF/MAPK scaffolds [cytosol] (Sus scrofa)
Focal Adhesion/Focal contacts [plasma membrane] (Sus scrofa)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Sus scrofa)
Focal complex [plasma membrane] (Sus scrofa)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Sus scrofa)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Sus scrofa)
RAF/MAPK scaffolds [cytosol] (Sus scrofa)
Focal Adhesion/Focal contacts [plasma membrane] (Sus scrofa)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Sus scrofa)
Focal complex [plasma membrane] (Sus scrofa)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Sus scrofa)
RAF/MAPK scaffolds [cytosol] (Sus scrofa)
Focal Adhesion/Focal contacts [plasma membrane] (Sus scrofa)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Sus scrofa)
Focal complex [plasma membrane] (Sus scrofa)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors [plasma membrane] (Sus scrofa)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Sus scrofa)
RAF/MAPK scaffolds [cytosol] (Sus scrofa)
Focal Adhesion/Focal contacts [plasma membrane] (Sus scrofa)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Sus scrofa)
Focal complex [plasma membrane] (Sus scrofa)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Sus scrofa)
RAF/MAPK scaffolds [cytosol] (Sus scrofa)
Focal Adhesion/Focal contacts [plasma membrane] (Sus scrofa)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Sus scrofa)
Focal complex [plasma membrane] (Sus scrofa)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
RAF phosphorylates MAP2K dimer (Sus scrofa)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Sus scrofa)
RAF/MAPK scaffolds [cytosol] (Sus scrofa)
Focal Adhesion/Focal contacts [plasma membrane] (Sus scrofa)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Sus scrofa)
Focal complex [plasma membrane] (Sus scrofa)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Sus scrofa)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Sus scrofa)
RAF/MAPK scaffolds [cytosol] (Sus scrofa)
Focal Adhesion/Focal contacts [plasma membrane] (Sus scrofa)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Sus scrofa)
Focal complex [plasma membrane] (Sus scrofa)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Sus scrofa)
RAF/MAPK scaffolds [cytosol] (Sus scrofa)
Focal Adhesion/Focal contacts [plasma membrane] (Sus scrofa)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Sus scrofa)
Focal complex [plasma membrane] (Sus scrofa)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks (Sus scrofa)
activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Sus scrofa)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Sus scrofa)
RAF/MAPK scaffolds [cytosol] (Sus scrofa)
Focal Adhesion/Focal contacts [plasma membrane] (Sus scrofa)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Sus scrofa)
Focal complex [plasma membrane] (Sus scrofa)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Sus scrofa)
RAF/MAPK scaffolds [cytosol] (Sus scrofa)
Focal Adhesion/Focal contacts [plasma membrane] (Sus scrofa)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Sus scrofa)
Focal complex [plasma membrane] (Sus scrofa)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Single mechanism MAPK inhibitors bind phosphorylated MAPK (Sus scrofa)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Sus scrofa)
RAF/MAPK scaffolds [cytosol] (Sus scrofa)
Focal Adhesion/Focal contacts [plasma membrane] (Sus scrofa)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Sus scrofa)
Focal complex [plasma membrane] (Sus scrofa)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK:single mechanism MAPK inhibitors [plasma membrane] (Sus scrofa)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Sus scrofa)
RAF/MAPK scaffolds [cytosol] (Sus scrofa)
Focal Adhesion/Focal contacts [plasma membrane] (Sus scrofa)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Sus scrofa)
Focal complex [plasma membrane] (Sus scrofa)
Integrin binding divalent cations [extracellular region]
Mg2+ [extracellular region]
Transport of small molecules (Sus scrofa)
Miscellaneous transport and binding events (Sus scrofa)
MAGT1 transports Mg2+ from extracellular region to cytosol (Sus scrofa)
Mg2+ [extracellular region]
NIPAs transport Mg2+ from extracellular region to cytosol (Sus scrofa)
Mg2+ [extracellular region]
TUSC3 transports Mg2+ from extracellular region to cytosol (Sus scrofa)
Mg2+ [extracellular region]
SLC-mediated transmembrane transport (Sus scrofa)
Transport of bile salts and organic acids, metal ions and amine compounds (Sus scrofa)
Metal ion SLC transporters (Sus scrofa)
SLC41A1,2 transport Mg2+ from extracellular region to cytosol (Sus scrofa)
Mg2+ [extracellular region]
Extracellular matrix organization (Xenopus tropicalis)
Integrin cell surface interactions (Xenopus tropicalis)
Collagen type I binds integrin alpha11beta1 (Xenopus tropicalis)
Mg2+ [extracellular region]
Collagen type I:Mg2+:Integrin alpha 11 beta 1 [plasma membrane] (Xenopus tropicalis)
Mg2+ [extracellular region]
Collagen type II binds integrin alpha10beta1 (Xenopus tropicalis)
Mg2+ [extracellular region]
Integrin alpha10beta1:Collagen type II fibril:Mg2+ [plasma membrane] (Xenopus tropicalis)
Mg2+ [extracellular region]
Hemostasis (Xenopus tropicalis)
Platelet activation, signaling and aggregation (Xenopus tropicalis)
Response to elevated platelet cytosolic Ca2+ (Xenopus tropicalis)
Platelet degranulation (Xenopus tropicalis)
Exocytosis of platelet dense granule content (Xenopus tropicalis)
Platelet dense granule content [extracellular region] (Xenopus tropicalis)
Mg2+ [extracellular region]
Platelet homeostasis (Xenopus tropicalis)
Platelet calcium homeostasis (Xenopus tropicalis)
Elevation of cytosolic Ca2+ levels (Xenopus tropicalis)
Cation influx mediated by TRPC3/6/7 (Xenopus tropicalis)
Cations [extracellular region]
Mg2+ [extracellular region]
Metabolism (Xenopus tropicalis)
Metabolism of nucleotides (Xenopus tropicalis)
Nucleotide catabolism (Xenopus tropicalis)
Phosphate bond hydrolysis by NTPDase proteins (Xenopus tropicalis)
NTPDase1 hydrolyzes nucleoside diphosphates (Xenopus tropicalis)
NTPDase1:Ca2+,Mg2+ [plasma membrane] (Xenopus tropicalis)
Ca2+,Mg2+ [extracellular region]
Mg2+ [extracellular region]
NTPDase1 hydrolyzes nucleoside triphosphates (Xenopus tropicalis)
NTPDase1:Ca2+,Mg2+ [plasma membrane] (Xenopus tropicalis)
Ca2+,Mg2+ [extracellular region]
Mg2+ [extracellular region]
NTPDase2 hydrolyzes nucleoside triphosphates (Xenopus tropicalis)
NTPDase2:Ca2+,Mg2+ [plasma membrane] (Xenopus tropicalis)
Ca2+,Mg2+ [extracellular region]
Mg2+ [extracellular region]
NTPDase3 hydrolyzes nucleoside diphosphates (Xenopus tropicalis)
NTPDase3:Ca2+,Mg2+ [plasma membrane] (Xenopus tropicalis)
Ca2+,Mg2+ [extracellular region]
Mg2+ [extracellular region]
NTPDase3 hydrolyzes nucleoside triphosphates (Xenopus tropicalis)
NTPDase3:Ca2+,Mg2+ [plasma membrane] (Xenopus tropicalis)
Ca2+,Mg2+ [extracellular region]
Mg2+ [extracellular region]
NTPDase6 hydrolyzes nucleoside diphosphates (Xenopus tropicalis)
NTPDase6:Ca2+,Mg2+ [extracellular region] (Xenopus tropicalis)
Ca2+,Mg2+ [extracellular region]
Mg2+ [extracellular region]
NTPDase8 hydrolyzes nucleoside diphosphates (Xenopus tropicalis)
NTPDase8:Ca2+,Mg2+ [plasma membrane] (Xenopus tropicalis)
Ca2+,Mg2+ [extracellular region]
Mg2+ [extracellular region]
NTPDase8 hydrolyzes nucleoside triphosphates (Xenopus tropicalis)
NTPDase8:Ca2+,Mg2+ [plasma membrane] (Xenopus tropicalis)
Ca2+,Mg2+ [extracellular region]
Mg2+ [extracellular region]
Transport of small molecules (Xenopus tropicalis)
Miscellaneous transport and binding events (Xenopus tropicalis)
NIPAs transport Mg2+ from extracellular region to cytosol (Xenopus tropicalis)
Mg2+ [extracellular region]
SLC-mediated transmembrane transport (Xenopus tropicalis)
Transport of bile salts and organic acids, metal ions and amine compounds (Xenopus tropicalis)
Metal ion SLC transporters (Xenopus tropicalis)
SLC41A1,2 transport Mg2+ from extracellular region to cytosol (Xenopus tropicalis)
Mg2+ [extracellular region]
External Reference Information
External Reference
magnesium(2+) [ChEBI:18420]
Participates
as a component of
Grin1:Grin2 di-heterotetramers:Mg2+ [plasma membrane] (Rattus norvegicus)
GRIN1:GRIN2 NMDA receptors:PSD proteins:Mg2+ [plasma membrane] (Homo sapiens)
Integrin alphaDbeta2:fibrin multimer:Mg++ [plasma membrane] (Homo sapiens)
Integrin alphaDbeta2:fibrin multimer:Mg++ [plasma membrane] (Gallus gallus)
Integrin alphaDbeta2:fibrin multimer:Mg++ [plasma membrane] (Mus musculus)
Integrin alphaDbeta2:fibrin multimer:Mg++ [plasma membrane] (Rattus norvegicus)
Integrin alphaDbeta2:fibrin multimer:Mg++ [plasma membrane] (Sus scrofa)
Integrin alpha10beta1:Collagen type II fibril:Mg2+ [plasma membrane] (Homo sapiens)
Integrin alpha10beta1:Collagen type II fibril:Mg2+ [plasma membrane] (Sus scrofa)
Integrin alpha10beta1:Collagen type II fibril:Mg2+ [plasma membrane] (Canis familiaris)
Integrin alpha10beta1:Collagen type II fibril:Mg2+ [plasma membrane] (Xenopus tropicalis)
Integrin alpha10beta1:Collagen type II fibril:Mg2+ [plasma membrane] (Caenorhabditis elegans)
Integrin alpha10beta1:Collagen type II fibril:Mg2+ [plasma membrane] (Rattus norvegicus)
Integrin alpha10beta1:Collagen type II fibril:Mg2+ [plasma membrane] (Bos taurus)
Integrin alpha10beta1:Collagen type II fibril:Mg2+ [plasma membrane] (Mus musculus)
Integrins alpha1beta1, alpha2beta1:Collagen type IV networks:Mg2+ [plasma membrane] (Homo sapiens)
Collagen type I:Mg2+:Integrin alpha 11 beta 1 [plasma membrane] (Homo sapiens)
Collagen type I:Mg2+:Integrin alpha 11 beta 1 [plasma membrane] (Gallus gallus)
Collagen type I:Mg2+:Integrin alpha 11 beta 1 [plasma membrane] (Rattus norvegicus)
Collagen type I:Mg2+:Integrin alpha 11 beta 1 [plasma membrane] (Mus musculus)
Collagen type I:Mg2+:Integrin alpha 11 beta 1 [plasma membrane] (Canis familiaris)
Collagen type I:Mg2+:Integrin alpha 11 beta 1 [plasma membrane] (Sus scrofa)
Collagen type I:Mg2+:Integrin alpha 11 beta 1 [plasma membrane] (Bos taurus)
Collagen type I:Mg2+:Integrin alpha 11 beta 1 [plasma membrane] (Xenopus tropicalis)
Collagen type I:Mg2+:Integrin alpha 11 beta 1 [plasma membrane] (Caenorhabditis elegans)
as an input of
TUSC3 transports Mg2+ from extracellular region to cytosol (Plasmodium falciparum)
TUSC3 transports Mg2+ from extracellular region to cytosol (Saccharomyces cerevisiae)
TUSC3 transports Mg2+ from extracellular region to cytosol (Schizosaccharomyces pombe)
TUSC3 transports Mg2+ from extracellular region to cytosol (Dictyostelium discoideum)
TUSC3 transports Mg2+ from extracellular region to cytosol (Caenorhabditis elegans)
TUSC3 transports Mg2+ from extracellular region to cytosol (Drosophila melanogaster)
TUSC3 transports Mg2+ from extracellular region to cytosol (Gallus gallus)
TUSC3 transports Mg2+ from extracellular region to cytosol (Sus scrofa)
TUSC3 transports Mg2+ from extracellular region to cytosol (Bos taurus)
TUSC3 transports Mg2+ from extracellular region to cytosol (Canis familiaris)
TUSC3 transports Mg2+ from extracellular region to cytosol (Rattus norvegicus)
TUSC3 transports Mg2+ from extracellular region to cytosol (Mus musculus)
TUSC3 transports Mg2+ from extracellular region to cytosol (Homo sapiens)
NIPAs transport Mg2+ from extracellular region to cytosol (Caenorhabditis elegans)
NIPAs transport Mg2+ from extracellular region to cytosol (Drosophila melanogaster)
NIPAs transport Mg2+ from extracellular region to cytosol (Gallus gallus)
NIPAs transport Mg2+ from extracellular region to cytosol (Xenopus tropicalis)
NIPAs transport Mg2+ from extracellular region to cytosol (Danio rerio)
NIPAs transport Mg2+ from extracellular region to cytosol (Sus scrofa)
NIPAs transport Mg2+ from extracellular region to cytosol (Bos taurus)
NIPAs transport Mg2+ from extracellular region to cytosol (Canis familiaris)
NIPAs transport Mg2+ from extracellular region to cytosol (Rattus norvegicus)
NIPAs transport Mg2+ from extracellular region to cytosol (Mus musculus)
NIPAs transport Mg2+ from extracellular region to cytosol (Homo sapiens)
MAGT1 transports Mg2+ from extracellular region to cytosol (Plasmodium falciparum)
MAGT1 transports Mg2+ from extracellular region to cytosol (Saccharomyces cerevisiae)
MAGT1 transports Mg2+ from extracellular region to cytosol (Schizosaccharomyces pombe)
MAGT1 transports Mg2+ from extracellular region to cytosol (Dictyostelium discoideum)
MAGT1 transports Mg2+ from extracellular region to cytosol (Caenorhabditis elegans)
MAGT1 transports Mg2+ from extracellular region to cytosol (Drosophila melanogaster)
MAGT1 transports Mg2+ from extracellular region to cytosol (Gallus gallus)
MAGT1 transports Mg2+ from extracellular region to cytosol (Danio rerio)
MAGT1 transports Mg2+ from extracellular region to cytosol (Sus scrofa)
MAGT1 transports Mg2+ from extracellular region to cytosol (Bos taurus)
MAGT1 transports Mg2+ from extracellular region to cytosol (Canis familiaris)
MAGT1 transports Mg2+ from extracellular region to cytosol (Rattus norvegicus)
MAGT1 transports Mg2+ from extracellular region to cytosol (Mus musculus)
MAGT1 transports Mg2+ from extracellular region to cytosol (Homo sapiens)
SLC41A1,2 transport Mg2+ from extracellular region to cytosol (Caenorhabditis elegans)
SLC41A1,2 transport Mg2+ from extracellular region to cytosol (Drosophila melanogaster)
SLC41A1,2 transport Mg2+ from extracellular region to cytosol (Gallus gallus)
SLC41A1,2 transport Mg2+ from extracellular region to cytosol (Xenopus tropicalis)
SLC41A1,2 transport Mg2+ from extracellular region to cytosol (Danio rerio)
SLC41A1,2 transport Mg2+ from extracellular region to cytosol (Sus scrofa)
SLC41A1,2 transport Mg2+ from extracellular region to cytosol (Bos taurus)
SLC41A1,2 transport Mg2+ from extracellular region to cytosol (Canis familiaris)
SLC41A1,2 transport Mg2+ from extracellular region to cytosol (Rattus norvegicus)
SLC41A1,2 transport Mg2+ from extracellular region to cytosol (Mus musculus)
SLC41A1,2 transport Mg2+ from extracellular region to cytosol (Homo sapiens)
Mg2+ binds Grin1:Grin2 NMDA receptors (Rattus norvegicus)
Mg2+ binds GRIN1:GRIN2 NMDA receptors (Homo sapiens)
Collagen type I binds integrin alpha11beta1 (Caenorhabditis elegans)
Collagen type I binds integrin alpha11beta1 (Gallus gallus)
Collagen type I binds integrin alpha11beta1 (Xenopus tropicalis)
Collagen type I binds integrin alpha1beta1, alpha2beta1, alpha10beta1 (Homo sapiens)
Interaction of integrin alphaDbeta2 with fibrin (Homo sapiens)
Interaction of integrin alphaDbeta2 with fibrin (Mus musculus)
Interaction of integrin alphaDbeta2 with fibrin (Rattus norvegicus)
Interaction of integrin alphaDbeta2 with fibrin (Sus scrofa)
Interaction of integrin alphaDbeta2 with fibrin (Gallus gallus)
Collagen type II binds integrin alpha10beta1 (Homo sapiens)
Collagen type II binds integrin alpha10beta1 (Mus musculus)
Collagen type II binds integrin alpha10beta1 (Rattus norvegicus)
Collagen type II binds integrin alpha10beta1 (Canis familiaris)
Collagen type II binds integrin alpha10beta1 (Bos taurus)
Collagen type II binds integrin alpha10beta1 (Sus scrofa)
Collagen type II binds integrin alpha10beta1 (Xenopus tropicalis)
Collagen type II binds integrin alpha10beta1 (Caenorhabditis elegans)
Collagen type IV networks bind integrins alpha1beta1, alpha2beta1 (Homo sapiens)
Collagen type I binds integrin alpha11beta1 (Homo sapiens)
Collagen type I binds integrin alpha11beta1 (Mus musculus)
Collagen type I binds integrin alpha11beta1 (Rattus norvegicus)
Collagen type I binds integrin alpha11beta1 (Canis familiaris)
Collagen type I binds integrin alpha11beta1 (Bos taurus)
Collagen type I binds integrin alpha11beta1 (Sus scrofa)
as an output of
Unblocking of Grin1:Grin2 NMDA receptors (Rattus norvegicus)
Unblocking of GRIN1:GRIN2 NMDA receptors (Homo sapiens)
as a member of
Cations [extracellular region]
Platelet dense granule content [extracellular region] (Drosophila melanogaster)
Platelet dense granule content [extracellular region] (Gallus gallus)
Platelet dense granule content [extracellular region] (Saccharomyces cerevisiae)
Platelet dense granule content [extracellular region] (Plasmodium falciparum)
Platelet dense granule content [extracellular region] (Mus musculus)
Platelet dense granule content [extracellular region] (Xenopus tropicalis)
Platelet dense granule content [extracellular region] (Dictyostelium discoideum)
Platelet dense granule content [extracellular region] (Sus scrofa)
Platelet dense granule content [extracellular region] (Rattus norvegicus)
Platelet dense granule content [extracellular region] (Canis familiaris)
Platelet dense granule content [extracellular region] (Caenorhabditis elegans)
Platelet dense granule content [extracellular region] (Danio rerio)
Platelet dense granule content [extracellular region] (Bos taurus)
Platelet dense granule content [extracellular region] (Schizosaccharomyces pombe)
Platelet dense granule content [extracellular region] (Homo sapiens)
Ca2+,Mg2+ [extracellular region]
as a candidate of
Integrin binding divalent cations [extracellular region]
This entity regulates
Positively
Formation of C4b:factor B complex
(Gallus gallus)
Complement factor B binds to surface-bound C3b fragment
(Gallus gallus)
Other forms of this molecule
Mg2+ [mitochondrial outer membrane]
Mg2+ [platelet dense granule lumen]
Mg2+ [Golgi lumen]
Mg2+ [nucleoplasm]
Mg2+ [peroxisomal matrix]
Mg2+ [plasma membrane]
Mg2+ [mitochondrial matrix]
Mg2+ [Golgi membrane]
Mg2+ [endoplasmic reticulum membrane]
Mg2+ [cytosol]
Cross References
COMPOUND
C00305
PubChem Substance
11533268
HMDB Metabolite
HMDB0000547
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