Reactome | p-6Y-VEGFR2 binds SHB

p-6Y-VEGFR2 binds SHB

Stable Identifier

R-HSA-4420099

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane, cytosol

ReviewStatus

5/5

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The adaptor protein SHB (Src homology 2 domain-containing adapter protein B) binds to phosphorylated tyrosine Y1175 in VEGFR2 and regulates the PTK2/FAK activity and endothelial cell migration. The SH2 domain located in the C-terminus of SHB interacts with the phosphotyrosine residue in VEGFR2 (Holmqvist et al. 2004). SHB is not required for vascular development, but SHB-deficient mice shows diffects in vessel functionality (Christoffersson et al. 2012) and impaired tumor growth (Funa et al. 2009).

Literature References

PubMed ID	Title	Journal	Year
15026417	The adaptor protein shb binds to tyrosine 1175 in vascular endothelial growth factor (VEGF) receptor-2 and regulates VEGF-dependent cellular migration Rolny, C, Welsh, M, Rahimi, N, Cross, MJ, Holmqvist, K, Matsumoto, T, Claesson-Welsh, L, Hägerkvist, R	J. Biol. Chem.	2004