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SHB [cytosol]
Stable Identifier
R-HSA-4420213
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
SH2 domain-containing adapter protein B, SHB_HUMAN
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by VEGF (Homo sapiens)
VEGFA-VEGFR2 Pathway (Homo sapiens)
SRC-1 phosphorylates SHB (Homo sapiens)
VEGFA dimer:p-6Y-VEGFR2 dimer:SHB [plasma membrane] (Homo sapiens)
SHB [cytosol] (Homo sapiens)
p-6Y-VEGFR2 binds SHB (Homo sapiens)
SHB [cytosol] (Homo sapiens)
VEGFA dimer:p-6Y-VEGFR2 dimer:SHB [plasma membrane] (Homo sapiens)
SHB [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q15464 SHB
Gene Names
SHB
Chain
chain:1-509
Reference Genes
BioGPS Gene:6461 SHB
COSMIC (genes):SHB SHB
CTD Gene:6461 SHB
dbSNP Gene:6461 SHB
ENSEMBL:ENSG00000107338.10 SHB
HGNC:10838 SHB
KEGG Gene (Homo sapiens):6461 SHB
Monarch:6461 SHB
NCBI Gene:6461 SHB
OMIM:600314 SHB
UCSC:Q15464 SHB
Reference Transcript
RefSeq:NM_003028.2 SHB
Other Identifiers
11732256_at
11732257_at
1557458_PM_s_at
1557458_s_at
17094064
204656_PM_at
204656_at
204657_3p_s_at
204657_PM_s_at
204657_s_at
243595_PM_at
243595_at
3205661
3205662
3205663
3205664
3205665
3205666
3205667
3205668
3205669
3205683
3205684
3205694
3205722
3205736
3205737
3205738
3205739
3205740
40614_at
60524_at
6461
73118_at
8161255
81629_r_at
A_23_P257743
A_24_P146575
GE61717
GE795573
GO:0000278
GO:0001525
GO:0001568
GO:0001784
GO:0002376
GO:0005515
GO:0005634
GO:0005654
GO:0005737
GO:0005829
GO:0005886
GO:0006469
GO:0006915
GO:0007155
GO:0007165
GO:0012501
GO:0016020
GO:0022414
GO:0023052
GO:0030097
GO:0030154
GO:0030159
GO:0036211
GO:0036464
GO:0042100
GO:0043226
GO:0045624
GO:0045931
GO:0048514
GO:0048856
GO:0050852
GO:0060090
GO:0071425
GO:1900194
HMNXSV003005297
Hs.244542.0.A2_3p_at
Hs.255531.0.A1_3p_at
ILMN_1732612
PH_hs_0013460
PH_hs_0018424
TC09002491.hg
TC09002893.hg
X75342_at
g4506934_3p_a_at
g4506934_3p_s_at
Participates
as an input of
p-6Y-VEGFR2 binds SHB (Homo sapiens)
as a component of
VEGFA dimer:p-6Y-VEGFR2 dimer:SHB [plasma membrane] (Homo sapiens)
Other forms of this molecule
pS-SHB [cytosol]
Inferred To
SHB [cytosol]
(Bos taurus)
SHB [cytosol]
(Canis familiaris)
SHB [cytosol]
(Gallus gallus)
SHB [cytosol]
(Sus scrofa)
hwt [cytosol]
(Drosophila melanogaster)
Shb [cytosol]
(Mus musculus)
Shb [cytosol]
(Rattus norvegicus)
shf [cytosol]
(Xenopus tropicalis)
Cross References
RefSeq
NP_003019.2
OpenTargets
ENSG00000107338
HPA
ENSG00000107338-SHB
GeneCards
Q15464
Ensembl
ENSG00000107338
,
ENST00000377707
,
ENSP00000366936
PRO
Q15464
Pharos - Targets
Q15464
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P00519 ABL1
5
p-Y226,Y393-ABL1 [nucleoplasm]
(R-HSA-8985251)
ABL1 [cytosol]
(R-HSA-375987)
p-Y226,Y393-ABL1 [cytosol]
(R-HSA-8942610)
ABL1 [nucleoplasm]
(R-HSA-5686579)
p-S456-ABL1 [nucleoplasm]
(R-HSA-5686576)
0.524
5
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