p-Y348-SYK binds VAV family

Stable Identifier
R-HSA-437932
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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p-Y348-SYK binds VAV family
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
The SH2 region of Vav1 binds to Syk at a site including phosphorylated tyrosine Y348. Mutation of this residue to F abolishes binding and subsequent Vav1 phosphorylation. Vav2 has also been shown to bind Syk.
Participants
Input
Output
Participates
as an event of
Inferred From
Pig Syk binds human Vav1 (Sus scrofa)
Syk binds Vav2 (Mus musculus)
Authored
Akkerman, JW  (2009-09-04)
Reviewed
Kunapuli, SP  (2010-06-07)
Created
Jupe, S  (2009-09-18)
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