SLC30A8 transports Zn2+ from cytosol to secretory granule

Stable Identifier
R-HSA-437136
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Golgi membrane
Synonyms
ZnT8 transports zinc into the secretory vesicles of pancreatic beta cells specifically
ReviewStatus
5/5
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SLC30A8 transports Zn2+ from cytosol to secretory granule
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The human SLC30A8 gene encodes the zinc transporter ZnT8 which is specifically expressed in pancreatic beta cells (Chimienti et al. 2005). SLC30A8 utilizes the antiport of two protons to achieve electroneutral transport (Xue et al., 2020). Zinc is required for zinc-insulin crystallization within secretory vesicles of these cells. After glucose stimulation, large amounts of zinc are secreted locally in the extracellular matrix together with insulin. It has been suggested that this co-secreted zinc plays a role in islet cell paracrine and/or autocrine communication (Chimienti F et al, 2006). Loss of function mutations in SLC30A8 are strongly protective against type 2 diabetes, suggesting SLC20A8 inhibition as a therapeutic target in T2D prevention. (Flannick et al. 2014).
Literature References
PubMed ID Title Journal Year
32723473 Cryo-EM structures of human ZnT8 in both outward- and inward-facing conformations

Xue, J, Xie, T, Zeng, W, Jiang, Y, Bai, XC

Elife 2020
16158222 ZnT-8, a pancreatic beta-cell-specific zinc transporter

Chimienti, F, Favier, A, Seve, M

Biometals 2005
16984975 In vivo expression and functional characterization of the zinc transporter ZnT8 in glucose-induced insulin secretion

Chimienti, F, Devergnas, S, Pattou, F, Schuit, F, Garcia-Cuenca, R, Vandewalle, B, Kerr-Conte, J, Van Lommel, L, Grunwald, D, Favier, A, Seve, M

J Cell Sci 2006
Participants
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Output
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as an event of
Catalyst Activity

zinc ion transmembrane transporter activity of SLC30A8 [secretory granule membrane]

Physical Entity
SLC30A8 [secretory granule membrane] (Homo sapiens)
Activity
zinc ion transmembrane transporter activity (GO:0005385)
Orthologous Events
SLC30A8 transports Zn2+ from cytosol to secretory granule (Bos taurus)
SLC30A8 transports Zn2+ from cytosol to secretory granule (Caenorhabditis elegans)
SLC30A8 transports Zn2+ from cytosol to secretory granule (Canis familiaris)
SLC30A8 transports Zn2+ from cytosol to secretory granule (Dictyostelium discoideum)
SLC30A8 transports Zn2+ from cytosol to secretory granule (Drosophila melanogaster)
SLC30A8 transports Zn2+ from cytosol to secretory granule (Gallus gallus)
SLC30A8 transports Zn2+ from cytosol to secretory granule (Mus musculus)
SLC30A8 transports Zn2+ from cytosol to secretory granule (Plasmodium falciparum)
SLC30A8 transports Zn2+ from cytosol to secretory granule (Rattus norvegicus)
SLC30A8 transports Zn2+ from cytosol to secretory granule (Sus scrofa)
SLC30A8 transports Zn2+ from cytosol to secretory granule (Xenopus tropicalis)
Cross References
RHEA
Authored
Jassal, B  (2009-09-11)
Reviewed
He, L  (2009-11-12)
D'Eustachio, P  (2025-08-12)
Created
Jassal, B  (2009-09-11)
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