SLC30A8 transports Zn2+ from cytosol to secretory granule

Stable Identifier
R-HSA-437136
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
ZnT8 transports zinc into the secretory vesicles of pancreatic beta cells specifically
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The human SLC30A8 gene encodes the zinc transporter ZnT8 which is specifically expressed in pancreatic beta cells (Chimienti et al. 2005). Zinc is required for zinc-insulin crystallization within secretory vesicles of these cells. After glucose stimulation, large amounts of zinc are secreted locally in the extracellular matrix together with insulin. It has been suggested that this co-secreted zinc plays a role in islet cell paracrine and/or autocrine communication (Chimienti F et al, 2006). Loss of function mutations in SLC30A8 are strongly protective against type 2 diabetes, suggesting SLC20A8 inhibition as a therapeutic target in T2D prevention. (Flannick et al. 2014).

Literature References
PubMed ID Title Journal Year
16984975 In vivo expression and functional characterization of the zinc transporter ZnT8 in glucose-induced insulin secretion

Chimienti, F, Devergnas, S, Pattou, F, Schuit, F, Garcia-Cuenca, R, Vandewalle, B, Kerr-Conte, J, Van Lommel, L, Grunwald, D, Favier, A, Seve, M

J Cell Sci 2006
16158222 ZnT-8, a pancreatic beta-cell-specific zinc transporter

Chimienti, F, Favier, A, Seve, M

Biometals 2005
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
zinc ion transmembrane transporter activity of SLC30A8 [secretory granule membrane]
Physical Entity
Activity
Orthologous Events
Cross References
Rhea
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