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Zinc efflux and compartmentalization by the SLC30 family
Stable Identifier
R-HSA-435368
DOI
10.3180/R-HSA-435368.3
Type
Pathway
Species
Homo sapiens
ReviewStatus
5/5
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Transport of small molecules (Homo sapiens)
SLC-mediated transmembrane transport (Homo sapiens)
Transport of bile salts and organic acids, metal ions and amine compounds (Homo sapiens)
Metal ion SLC transporters (Homo sapiens)
Zinc transporters (Homo sapiens)
Zinc efflux and compartmentalization by the SLC30 family (Homo sapiens)
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The human SLC30 gene family of solute carriers is thought to participate in the homeostasis of zinc ions and facilitate zinc transport into specialized compartments of the cell such as endosomes, golgi network and synaptic vesicles. There are 10 members of this family, named ZnT1-10. ZnT4, ZnT9 and ZnT10 have no function determined as of yet (Palmiter RD and Huang L, 2004).
Literature References
PubMed ID
Title
Journal
Year
12748859
Efflux and compartmentalization of zinc by members of the SLC30 family of solute carriers
Palmiter, RD
,
Huang, L
Pflugers Arch
2004
Participants
Events
ZnT1 mediates the efflux of zinc from the cell
(Homo sapiens)
ZnT2 facilitates zinc vesicular sequestration
(Homo sapiens)
ZnT3 transports zinc into synaptic vesicles
(Homo sapiens)
ZnT5 transports zinc into secretory granules in pancreatic beta cells
(Homo sapiens)
ZnT8 transports zinc into the Golgi apparatus
(Homo sapiens)
ZnT5 transports zinc into the golgi apparatus
(Homo sapiens)
SLC30A8 transports Zn2+ from cytosol to secretory granule
(Homo sapiens)
Participates
as an event of
Zinc transporters (Homo sapiens)
Event Information
Go Biological Process
zinc ion transmembrane transport (0071577)
Orthologous Events
Zinc efflux and compartmentalization by the SLC30 family (Bos taurus)
Zinc efflux and compartmentalization by the SLC30 family (Caenorhabditis elegans)
Zinc efflux and compartmentalization by the SLC30 family (Canis familiaris)
Zinc efflux and compartmentalization by the SLC30 family (Danio rerio)
Zinc efflux and compartmentalization by the SLC30 family (Dictyostelium discoideum)
Zinc efflux and compartmentalization by the SLC30 family (Drosophila melanogaster)
Zinc efflux and compartmentalization by the SLC30 family (Gallus gallus)
Zinc efflux and compartmentalization by the SLC30 family (Mus musculus)
Zinc efflux and compartmentalization by the SLC30 family (Plasmodium falciparum)
Zinc efflux and compartmentalization by the SLC30 family (Rattus norvegicus)
Zinc efflux and compartmentalization by the SLC30 family (Saccharomyces cerevisiae)
Zinc efflux and compartmentalization by the SLC30 family (Schizosaccharomyces pombe)
Zinc efflux and compartmentalization by the SLC30 family (Sus scrofa)
Zinc efflux and compartmentalization by the SLC30 family (Xenopus tropicalis)
Authored
Jassal, B (2009-09-09)
Reviewed
He, L (2009-11-12)
Created
Jassal, B (2009-09-09)
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