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PI3K beta [cytosol]
Stable Identifier
R-HSA-437110
Type
Complex
Species
Homo sapiens
Compartment
cytosol
Locations in the PathwayBrowser
Expand all
Developmental Biology (Homo sapiens)
Nervous system development (Homo sapiens)
Axon guidance (Homo sapiens)
RET signaling (Homo sapiens)
p-5Y-GAB in the RET-GRB2-GAB complexes binds p85-PI3K (Homo sapiens)
2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1:p-5Y-GAB1,p-5Y-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Homo sapiens)
p85-containing Class 1A PI3Ks [cytosol] (Homo sapiens)
PI3K beta [cytosol] (Homo sapiens)
p85-containing Class 1A PI3Ks [cytosol] (Homo sapiens)
PI3K beta [cytosol] (Homo sapiens)
Disease (Homo sapiens)
Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
PI3K/AKT Signaling in Cancer (Homo sapiens)
Constitutive Signaling by Aberrant PI3K in Cancer (Homo sapiens)
PI3K inhibitors block PI3K catalytic activity (Homo sapiens)
PI3K Inhibitors:PI3K [cytosol] (Homo sapiens)
PI3K mutants,Activator:PI3K [plasma membrane] (Homo sapiens)
Activator:PI3K [plasma membrane] (Homo sapiens)
CD28:PI3K [plasma membrane] (Homo sapiens)
Class 1A PI3Ks [cytosol] (Homo sapiens)
PI3K beta [cytosol] (Homo sapiens)
ICOS:PI3K [plasma membrane] (Homo sapiens)
Class 1A PI3Ks [cytosol] (Homo sapiens)
PI3K beta [cytosol] (Homo sapiens)
PI3K mutants,Activator:PI3K [plasma membrane] (Homo sapiens)
Activator:PI3K [plasma membrane] (Homo sapiens)
CD28:PI3K [plasma membrane] (Homo sapiens)
Class 1A PI3Ks [cytosol] (Homo sapiens)
PI3K beta [cytosol] (Homo sapiens)
ICOS:PI3K [plasma membrane] (Homo sapiens)
Class 1A PI3Ks [cytosol] (Homo sapiens)
PI3K beta [cytosol] (Homo sapiens)
Hemostasis (Homo sapiens)
Platelet activation, signaling and aggregation (Homo sapiens)
GPVI-mediated activation cascade (Homo sapiens)
GPVI stimulates PI3K beta, gamma (Homo sapiens)
PI3K beta [cytosol] (Homo sapiens)
PI3K alpha, beta, gamma convert PIP2 to PIP3 (Homo sapiens)
PI3K alpha, beta, gamma [cytosol] (Homo sapiens)
PI3K beta [cytosol] (Homo sapiens)
Immune System (Homo sapiens)
Adaptive Immune System (Homo sapiens)
Regulation of T cell activation by CD28 family (Homo sapiens)
Co-stimulation by CD28 (Homo sapiens)
CD28 dependent PI3K/Akt signaling (Homo sapiens)
CD28 bound PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
CD28:PI3K [plasma membrane] (Homo sapiens)
Class 1A PI3Ks [cytosol] (Homo sapiens)
PI3K beta [cytosol] (Homo sapiens)
PI3K binds CD28 (Homo sapiens)
CD28:PI3K [plasma membrane] (Homo sapiens)
Class 1A PI3Ks [cytosol] (Homo sapiens)
PI3K beta [cytosol] (Homo sapiens)
Class 1A PI3Ks [cytosol] (Homo sapiens)
PI3K beta [cytosol] (Homo sapiens)
Co-stimulation by ICOS (Homo sapiens)
PI3K binds ICOS (Homo sapiens)
Class 1A PI3Ks [cytosol] (Homo sapiens)
PI3K beta [cytosol] (Homo sapiens)
ICOS:PI3K [plasma membrane] (Homo sapiens)
Class 1A PI3Ks [cytosol] (Homo sapiens)
PI3K beta [cytosol] (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Signaling by Interleukins (Homo sapiens)
Interleukin-2 family signaling (Homo sapiens)
Interleukin receptor SHC signaling (Homo sapiens)
Gab2 binds the p85 subunit of Class 1A PI3 kinases (Homo sapiens)
Interleukin receptor complexes with activated Shc:GRB2:p-GAB2:p85-containing Class 1 PI3Ks [plasma membrane] (Homo sapiens)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Homo sapiens)
High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Homo sapiens)
p85-containing Class 1A PI3Ks [cytosol] (Homo sapiens)
PI3K beta [cytosol] (Homo sapiens)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Homo sapiens)
p85-containing Class 1A PI3Ks [cytosol] (Homo sapiens)
PI3K beta [cytosol] (Homo sapiens)
IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Homo sapiens)
p85-containing Class 1A PI3Ks [cytosol] (Homo sapiens)
PI3K beta [cytosol] (Homo sapiens)
IL2:IL2R trimer p(Y338) beta subunit:p-SHC:GRB2:GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Homo sapiens)
p85-containing Class 1A PI3Ks [cytosol] (Homo sapiens)
PI3K beta [cytosol] (Homo sapiens)
p85-containing Class 1A PI3Ks [cytosol] (Homo sapiens)
PI3K beta [cytosol] (Homo sapiens)
Interleukin-3, Interleukin-5 and GM-CSF signaling (Homo sapiens)
14-3-3 zeta binding allows recruitment of PI3K (Homo sapiens)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(S589)-Bc:14-3-3 zeta:p85-containing Class 1A PI3Ks [plasma membrane] (Homo sapiens)
p85-containing Class 1A PI3Ks [cytosol] (Homo sapiens)
PI3K beta [cytosol] (Homo sapiens)
p85-containing Class 1A PI3Ks [cytosol] (Homo sapiens)
PI3K beta [cytosol] (Homo sapiens)
Interleukin receptor SHC signaling (Homo sapiens)
Gab2 binds the p85 subunit of Class 1A PI3 kinases (Homo sapiens)
Interleukin receptor complexes with activated Shc:GRB2:p-GAB2:p85-containing Class 1 PI3Ks [plasma membrane] (Homo sapiens)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Homo sapiens)
High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Homo sapiens)
p85-containing Class 1A PI3Ks [cytosol] (Homo sapiens)
PI3K beta [cytosol] (Homo sapiens)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Homo sapiens)
p85-containing Class 1A PI3Ks [cytosol] (Homo sapiens)
PI3K beta [cytosol] (Homo sapiens)
IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Homo sapiens)
p85-containing Class 1A PI3Ks [cytosol] (Homo sapiens)
PI3K beta [cytosol] (Homo sapiens)
IL2:IL2R trimer p(Y338) beta subunit:p-SHC:GRB2:GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Homo sapiens)
p85-containing Class 1A PI3Ks [cytosol] (Homo sapiens)
PI3K beta [cytosol] (Homo sapiens)
p85-containing Class 1A PI3Ks [cytosol] (Homo sapiens)
PI3K beta [cytosol] (Homo sapiens)
Regulation of signaling by CBL (Homo sapiens)
CBL is tyrosine phosphorylated (Homo sapiens)
FYN-like kinases:CBL:GRB2:p85-containing Class 1A PI3Ks [cytosol] (Homo sapiens)
p85-containing Class 1A PI3Ks [cytosol] (Homo sapiens)
PI3K beta [cytosol] (Homo sapiens)
FYN-like kinases:p(Y731)-CBL:GRB2:p85-containing Class 1A PI3Ks [cytosol] (Homo sapiens)
p85-containing Class 1A PI3Ks [cytosol] (Homo sapiens)
PI3K beta [cytosol] (Homo sapiens)
CBL ubiquitinates PI3K (Homo sapiens)
FYN-like kinases:p(Y731)-CBL:GRB2:p85-containing Class 1A PI3Ks [cytosol] (Homo sapiens)
p85-containing Class 1A PI3Ks [cytosol] (Homo sapiens)
PI3K beta [cytosol] (Homo sapiens)
CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated (Homo sapiens)
FYN-like kinases:CBL:GRB2:p85-containing Class 1A PI3Ks [cytosol] (Homo sapiens)
p85-containing Class 1A PI3Ks [cytosol] (Homo sapiens)
PI3K beta [cytosol] (Homo sapiens)
p85-containing Class 1A PI3Ks [cytosol] (Homo sapiens)
PI3K beta [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
Intracellular signaling by second messengers (Homo sapiens)
PIP3 activates AKT signaling (Homo sapiens)
Negative regulation of the PI3K/AKT network (Homo sapiens)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Homo sapiens)
PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
Activator:PI3K [plasma membrane] (Homo sapiens)
CD28:PI3K [plasma membrane] (Homo sapiens)
Class 1A PI3Ks [cytosol] (Homo sapiens)
PI3K beta [cytosol] (Homo sapiens)
ICOS:PI3K [plasma membrane] (Homo sapiens)
Class 1A PI3Ks [cytosol] (Homo sapiens)
PI3K beta [cytosol] (Homo sapiens)
PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
Activator:PI3K [plasma membrane] (Homo sapiens)
CD28:PI3K [plasma membrane] (Homo sapiens)
Class 1A PI3Ks [cytosol] (Homo sapiens)
PI3K beta [cytosol] (Homo sapiens)
ICOS:PI3K [plasma membrane] (Homo sapiens)
Class 1A PI3Ks [cytosol] (Homo sapiens)
PI3K beta [cytosol] (Homo sapiens)
Participants
components
PI3K-regulatory subunits [cytosol]
(Homo sapiens)
PIK3CB [cytosol]
(Homo sapiens)
Participates
as a member of
p85-containing Class 1A PI3Ks [cytosol] (Homo sapiens)
PI3K alpha, beta, gamma [cytosol] (Homo sapiens)
as an output of
GPVI stimulates PI3K beta, gamma (Homo sapiens)
as a candidate of
Class 1A PI3Ks [cytosol] (Homo sapiens)
Inferred To
PI3K [cytosol]
(Drosophila melanogaster)
PI3K beta [cytosol]
(Bos taurus)
PI3K beta [cytosol]
(Canis familiaris)
PI3K beta [cytosol]
(Danio rerio)
PI3K beta [cytosol]
(Gallus gallus)
PI3K beta [cytosol]
(Mus musculus)
PI3K beta [cytosol]
(Rattus norvegicus)
PI3K beta [cytosol]
(Sus scrofa)
PI3K beta [cytosol]
(Xenopus tropicalis)
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