GPVI stimulates PI3K beta, gamma

Stable Identifier
R-HSA-437118
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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GPVI stimulates PI3K beta, gamma
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GPVI downstream signaling involves PI3K. Mouse knockouts of PI3Kbeta/PI3Kgamma suggest that though both isoforms are required for a full platelet response, only beta is absolutely required for Akt phosphorylation, Rap1 activation, and platelet aggregation downstream. The pathway connecting GPVI to PI3K is unclear. Two possible routes are suggested by interactions of the PI3K p85 regulatory subunit with LAT and with peptides representing the ITAM motif of Fc Epsilon R1 gamma.
Literature References
PubMed ID Title Journal Year
19700402 The role of PI 3-K{beta} in glycoprotein VI-mediated akt activation in platelets

Kim, S, Jackson, SP, Lillian, R, Dangelmaier, C, Mangin, P, Kunapuli, SP, Daniel, JL

J Biol Chem 2009
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Orthologous Events
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Authored
Akkerman, JW  (2009-09-04)
Reviewed
Harper, MT  (2009-11-02)
Poole, AW  (2009-11-02)
Jones, ML  (2009-11-02)
Created
Jupe, S  (2009-09-11)
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