ZnT2 facilitates zinc vesicular sequestration

Stable Identifier
R-HSA-435375
Type
Reaction [transition]
Species
Homo sapiens
Compartment
endosome membrane
ReviewStatus
5/5
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ZnT2 facilitates zinc vesicular sequestration
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The human gene SLC30A2 encodes zinc transporter ZnT2. Its function was first inferred from experiments using rat Znt2 (Palmiter RD et al, 1996). In 2019, Golan et al. showed in human cells that SLC30A2 uses antiport of two protons to achieve electroneutral zinc transport.
Literature References
PubMed ID Title Journal Year
30893306 ZnT2 is an electroneutral proton-coupled vesicular antiporter displaying an apparent stoichiometry of two protons per zinc ion

Golan, Y, Alhadeff, R, Warshel, A, Assaraf, YG

PLoS Comput Biol 2019
8617223 ZnT-2, a mammalian protein that confers resistance to zinc by facilitating vesicular sequestration

Palmiter, RD, Cole, TB, Findley, SD

EMBO J 1996
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Catalyst Activity

zinc ion transmembrane transporter activity of SLC30A2 [endosome membrane]

Physical Entity
SLC30A2 [endosome membrane] (Homo sapiens)
Activity
zinc ion transmembrane transporter activity (GO:0005385)
Inferred From
Znt2 facilitates zinc vesicular sequestration (Rattus norvegicus)
Cross References
RHEA
Authored
Jassal, B  (2009-09-09)
Reviewed
He, L  (2009-11-12)
D'Eustachio, P  (2025-08-12)
Created
Jassal, B  (2009-09-09)
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