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Zinc transporters
Stable Identifier
R-HSA-435354
Type
Pathway
Species
Homo sapiens
ReviewStatus
5/5
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Transport of small molecules (Homo sapiens)
SLC-mediated transmembrane transport (Homo sapiens)
Transport of bile salts and organic acids, metal ions and amine compounds (Homo sapiens)
Metal ion SLC transporters (Homo sapiens)
Zinc transporters (Homo sapiens)
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Zinc is an essential element for all organisms because it serves as a catalytic or structural cofactor for many different proteins. Cellular zinc homoeostasis is co-ordinated through Zn2+-specific transporters which are members of two distinct gene families. Members of the SLC39 gene family (ZRTL-like import proteins1-14, ZIP1-14) are responsible for Zn2+ import into the cytoplasm, either across the plasma membrane or out of intracellular organelles. In contrast, members of the SLC30 gene family (zinc transporters 1-10, ZnT1-10) export Zn2+ from the cytoplasm, either across the plasma membrane into the extracellular space or into intracellular organelles (Murakami M and Hirano T, 2008; Devirgiliis C et al, 2007; Eide DJ, 2006).
Literature References
PubMed ID
Title
Journal
Year
18754861
Intracellular zinc homeostasis and zinc signaling
Murakami, M
,
Hirano, T
Cancer Sci
2008
16675045
Zinc transporters and the cellular trafficking of zinc
Eide, DJ
Biochim Biophys Acta
2006
17374385
Zinc fluxes and zinc transporter genes in chronic diseases
Perozzi, G
,
Murgia, C
,
Devirgiliis, C
,
Zalewski, PD
Mutat Res
2007
Participants
Events
Zinc efflux and compartmentalization by the SLC30 family
(Homo sapiens)
Zinc influx into cells by the SLC39 gene family
(Homo sapiens)
Participates
as an event of
Metal ion SLC transporters (Homo sapiens)
Event Information
Go Biological Process
zinc ion transmembrane transport (0071577)
Orthologous Events
Zinc transporters (Bos taurus)
Zinc transporters (Caenorhabditis elegans)
Zinc transporters (Canis familiaris)
Zinc transporters (Danio rerio)
Zinc transporters (Dictyostelium discoideum)
Zinc transporters (Drosophila melanogaster)
Zinc transporters (Gallus gallus)
Zinc transporters (Mus musculus)
Zinc transporters (Plasmodium falciparum)
Zinc transporters (Rattus norvegicus)
Zinc transporters (Saccharomyces cerevisiae)
Zinc transporters (Schizosaccharomyces pombe)
Zinc transporters (Sus scrofa)
Zinc transporters (Xenopus tropicalis)
Authored
Jassal, B (2009-09-09)
Reviewed
He, L (2009-11-12)
Created
Jassal, B (2009-09-09)
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