Reactome | NR3C2 [nucleoplasm]

NR3C2 [nucleoplasm]

Stable Identifier

R-HSA-4341124

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Mineralocorticoid receptor, MCR_HUMAN

Icon

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:P08235 NR3C2

Gene Names

NR3C2, MCR, MLR

Chain

chain:1-984

Reference Genes

BioGPS Gene:4306 NR3C2

COSMIC (genes):NR3C2 NR3C2

CTD Gene:4306 NR3C2

dbSNP Gene:4306 NR3C2

ENSEMBL:ENSG00000151623 NR3C2

HGNC:7979 NR3C2

KEGG:hsa:4306 NR3C2

Monarch:4306 NR3C2

NCBI Gene:4306 NR3C2

OMIM:600983 NR3C2

UCSC:P08235 NR3C2

Reference Transcript

Participates

as an input of

PIAS1 SUMOylates NR3C2 (Mineralcorticoid Receptor) with SUMO1 (Homo sapiens)

as a component of

NR3C2:NR3C2 ligands [nucleoplasm] (Homo sapiens)

Other forms of this molecule

NR3C2 [cytosol]

monoSUMO1-K89,K399,K428.K494-NR3C2 [nucleoplasm]

Inferred To

Nr3c2 [nucleoplasm] (Mus musculus)

Nr3c2 [nucleoplasm] (Rattus norvegicus)

knrl [nucleoplasm] (Drosophila melanogaster)

Homologues of NR3C2-1 [nucleoplasm] (Drosophila melanogaster)

Ghost homologue of NR3C2 [nucleoplasm] (Plasmodium falciparum)

ERR [nucleoplasm] (Drosophila melanogaster)

NR3C2 [nucleoplasm] (Bos taurus)

NR3C2 [nucleoplasm] (Canis familiaris)

NR3C2 [nucleoplasm] (Gallus gallus)

NR3C2 [nucleoplasm] (Sus scrofa)

kni [nucleoplasm] (Drosophila melanogaster)

nr3c2 [nucleoplasm] (Danio rerio)

nr3c2 [nucleoplasm] (Xenopus tropicalis)

eg [nucleoplasm] (Drosophila melanogaster)

Cross References

RefSeq

XP_016863706.1, XP_011530279.1, XP_047271664.1, NP_001341748.1, XP_011530277.1, NP_001159576.1, XP_047271662.1, XP_011530278.1, NP_000892.2, XP_047271663.1

ZINC - World Drugs

MCR_HUMAN

Guide to Pharmacology - Targets

626

OpenTargets

ENSG00000151623

ENSEMBL

ENSP00000341390, ENSP00000486719, ENSG00000151623, ENST00000358102, ENST00000511528, ENST00000342437, ENST00000344721, ENSP00000343907, ENST00000625323, ENSP00000350815, ENST00000512865, ENSP00000421481, ENSP00000423510

ZINC - FDA approved

MCR_HUMAN

ZINC - Substances

MCR_HUMAN

ZINC - Biogenic

MCR_HUMAN

ZINC target

P08235

PRO

P08235

GlyGen

P08235

PDB

2AA2, 5L7E, 6GG8, 2AA5, 5L7H, 2AA7, 2AA6, 5HCV, 5L7G, 6GGG, 4TNT, 1Y9R, 3VHU, 3WFG, 4PF3, 5MWP, 2OAX, 2ABI, 2AAX, 2AB2, 2A3I, 3WFF, 6GEV, 6L88, 5MWY, 3VHV, 4UDA, 1YA3, 4UDB

ZINC - Investigational

MCR_HUMAN

ZINC - Metabolites

MCR_HUMAN

HPA

ENSG00000151623-NR3C2

GeneCards

NR3C2

Pharos - Targets

P08235

Orphanet

NR3C2

ZINC - Predictions - Purchasable

MCR_HUMAN

HMDB Protein

HMDBP02638

Interactors (4)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9Y4I5 MTL5			0.581	4
UniProt:Q8N4J0 CARNMT1	1	CARNMT1 [cytosol] (R-HSA-8876689)	0.527	3
UniProt:Q9UBK2 PPARGC1A	4	PPARGC1A [nucleoplasm] (R-HSA-442481) p-T178,S539-PPARGC1A [nucleoplasm] (R-HSA-1592204) p-T263,S266,T299-PPARGC1A [nucleoplasm] (R-HSA-1592224) monoSUMO1-K184-PPARGC1A [nucleoplasm] (R-HSA-3903023)	0.508	3
UniProt:Q15788 NCOA1	3	NCOA1 [nucleoplasm] (R-HSA-442496) NCOA1 (868-1441) [nucleoplasm] (R-HSA-5603230) monoSUMO1-K732,K774-NCOA1 [nucleoplasm] (R-HSA-4085291)	0.508	2

Cite Us!