Reactome | PIAS1 SUMOylates NR3C2 (Mineralcorticoid Receptor) with SUMO1

PIAS1 SUMOylates NR3C2 (Mineralcorticoid Receptor) with SUMO1

Stable Identifier

R-HSA-4341016

Type

Reaction [transition]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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PIAS1 SUMOylates NR3C2 (Mineralcorticoid Receptor) with SUMO1

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PIAS1 SUMOylates NR3C2 (Mineralcorticoid receptor, MR) at lysine-89, lysine-399, lysine-428, and lysine 494 with SUMO1 (Tallec et al. 2003, Tirard et al. 2007, Yokota et al. 2007). SUMOylation represses the transcription activation activity of NR3C2.

Literature References

PubMed ID	Title	Journal	Year
17105732	Coactivation of the N-terminal transactivation of mineralocorticoid receptor by Ubc9 Kobayashi, S, Shibata, H, Itoh, H, Suda, N, Murai-Takeda, A, Kurihara, I, Yokota, K, Kitagawa, H, Saruta, T, Kato, S, Saito, I	J. Biol. Chem.	2007
17314004	Sumoylation and proteasomal activity determine the transactivation properties of the mineralocorticoid receptor Tirard, M, Hutzler, P, Melchior, F, Michaelidis, TM, Almeida, OF	Mol. Cell. Endocrinol.	2007
14500761	Protein inhibitor of activated signal transducer and activator of transcription 1 interacts with the N-terminal domain of mineralocorticoid receptor and represses its transcriptional activity: implication of small ubiquitin-related modifier 1 modification Dejean, A, Zennaro, MC, Lecomte, MC, Viengchareun, S, Kirsh, O, Lombès, M, Tallec, LP	Mol. Endocrinol.	2003