PIAS1 SUMOylates NR3C2 (Mineralcorticoid Receptor) with SUMO1

Stable Identifier
Reaction [transition]
Homo sapiens
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PIAS1 SUMOylates NR3C2 (Mineralcorticoid receptor, MR) at lysine-89, lysine-399, lysine-428, and lysine 494 with SUMO1 (Tallec et al. 2003, Tirard et al. 2007, Yokota et al. 2007). SUMOylation represses the transcription activation activity of NR3C2.

Literature References
PubMed ID Title Journal Year
17105732 Coactivation of the N-terminal transactivation of mineralocorticoid receptor by Ubc9

Kobayashi, S, Shibata, H, Itoh, H, Suda, N, Murai-Takeda, A, Kurihara, I, Yokota, K, Kitagawa, H, Saruta, T, Kato, S, Saito, I

J. Biol. Chem. 2007
17314004 Sumoylation and proteasomal activity determine the transactivation properties of the mineralocorticoid receptor

Tirard, M, Hutzler, P, Melchior, F, Michaelidis, TM, Almeida, OF

Mol. Cell. Endocrinol. 2007
14500761 Protein inhibitor of activated signal transducer and activator of transcription 1 interacts with the N-terminal domain of mineralocorticoid receptor and represses its transcriptional activity: implication of small ubiquitin-related modifier 1 modification

Dejean, A, Zennaro, MC, Lecomte, MC, Viengchareun, S, Kirsh, O, Lomb├Ęs, M, Tallec, LP

Mol. Endocrinol. 2003
Catalyst Activity

SUMO transferase activity of PIAS1 [nucleoplasm]

Orthologous Events
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