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monoSUMO1-K89,K399,K428.K494-NR3C2 [nucleoplasm]
Stable Identifier
R-HSA-4341098
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Mineralocorticoid receptor, MCR_HUMAN
Icon
Locations in the PathwayBrowser
Expand all
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
SUMOylation (Homo sapiens)
SUMO E3 ligases SUMOylate target proteins (Homo sapiens)
SUMOylation of intracellular receptors (Homo sapiens)
PIAS1 SUMOylates NR3C2 (Mineralcorticoid Receptor) with SUMO1 (Homo sapiens)
monoSUMO1-K89,K399,K428.K494-NR3C2 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:P08235 NR3C2
Gene Names
NR3C2, MCR, MLR
Chain
chain:1-984
Reference Genes
BioGPS Gene:4306 NR3C2
COSMIC (genes):NR3C2 NR3C2
CTD Gene:4306 NR3C2
dbSNP Gene:4306 NR3C2
ENSEMBL:ENSG00000151623 NR3C2
ENSEMBL_homo_sapiens_GENE:ENSG00000151623.15 NR3C2
HGNC:7979 NR3C2
KEGG Gene (Homo sapiens):4306 NR3C2
Monarch:4306 NR3C2
NCBI Gene:4306 NR3C2
OMIM:600983 NR3C2
UCSC:P08235 NR3C2
Reference Transcript
RefSeq:NM_001166104.1 NR3C2
RefSeq:XM_011531976.2 NR3C2
RefSeq:XM_011531975.1 NR3C2
RefSeq:XM_017008217.1 NR3C2
RefSeq:XM_011531977.2 NR3C2
RefSeq:NM_000901.4 NR3C2
Other Identifiers
11723163_s_at
11746623_a_at
16980470
205259_PM_at
205259_at
2788927
2788928
2788942
2788943
2788950
2788954
2788955
2788956
2788957
2788958
2788973
2788974
2788992
2789010
2789013
2789014
33249_at
4306
8103094
A_23_P392470
GE57845
GO:0000785
GO:0000981
GO:0003677
GO:0003700
GO:0003707
GO:0004879
GO:0005496
GO:0005515
GO:0005634
GO:0005654
GO:0005694
GO:0005737
GO:0005783
GO:0005789
GO:0005829
GO:0006351
GO:0006355
GO:0006357
GO:0007165
GO:0008270
GO:0008289
GO:0016020
GO:0017025
GO:0023052
GO:0030518
GO:0034056
GO:0043226
GO:0043235
GO:0043565
GO:0046872
GO:0060089
GO:0140110
GO:1901224
GO:1990837
HMNXSV003026438
HMNXSV003056648
ILMN_2210934
M16801_at
PH_hs_0023835
TC04001627.hg
g4505198_3p_at
Participates
as an output of
PIAS1 SUMOylates NR3C2 (Mineralcorticoid Receptor) with SUMO1 (Homo sapiens)
Other forms of this molecule
NR3C2 [nucleoplasm]
NR3C2 [cytosol]
Inferred To
monoSUMO1-K89,K399,K428.K494-NR3C2 [nucleoplasm]
(Gallus gallus)
monoSUMO1-K89,K399,K428.K494-NR3C2 [nucleoplasm]
(Mus musculus)
monoSUMO1-K89,K399,K428.K494-NR3C2 [nucleoplasm]
(Rattus norvegicus)
NR3C2 [nucleoplasm]
(Bos taurus)
NR3C2 [nucleoplasm]
(Sus scrofa)
nr3c2 [nucleoplasm]
(Danio rerio)
nr3c2 [nucleoplasm]
(Xenopus tropicalis)
Modified Residues
Name
sumoylated lysine (monoSUMO1 [nucleoplasm]) at 89
Coordinate
89
Modification
monoSUMO1 [nucleoplasm]
PsiMod Name
sumoylated lysine
PsiMod Definition
A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a sumo (Small Ubiquitin-related MOdifier) protein.
Name
sumoylated lysine (monoSUMO1 [nucleoplasm]) at 399
Coordinate
399
Modification
monoSUMO1 [nucleoplasm]
PsiMod Name
sumoylated lysine
PsiMod Definition
A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a sumo (Small Ubiquitin-related MOdifier) protein.
Name
sumoylated lysine (monoSUMO1 [nucleoplasm]) at 428
Coordinate
428
Modification
monoSUMO1 [nucleoplasm]
PsiMod Name
sumoylated lysine
PsiMod Definition
A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a sumo (Small Ubiquitin-related MOdifier) protein.
Name
sumoylated lysine (monoSUMO1 [nucleoplasm]) at 494
Coordinate
494
Modification
monoSUMO1 [nucleoplasm]
PsiMod Name
sumoylated lysine
PsiMod Definition
A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a sumo (Small Ubiquitin-related MOdifier) protein.
Cross References
RefSeq
NP_001159576.1
,
XP_011530277.1
,
XP_011530278.1
,
XP_011530279.1
,
XP_016863706.1
,
NP_000892.2
ZINC - World Drugs
MCR_HUMAN
Guide to Pharmacology - Targets
626
OpenTargets
ENSG00000151623
ZINC - FDA approved
MCR_HUMAN
ZINC - Substances
MCR_HUMAN
ZINC - Biogenic
MCR_HUMAN
ZINC target
P08235
PRO
P08235
PDB
2ABI
,
5MWY
,
6GG8
,
6GEV
,
2A3I
,
3WFF
,
2AB2
,
4TNT
,
5L7E
,
2AA6
,
4PF3
,
3VHU
,
4UDB
,
6L88
,
5HCV
,
3WFG
,
2OAX
,
1YA3
,
5L7G
,
2AA5
,
6GGG
,
4UDA
,
5MWP
,
2AA2
,
5L7H
,
3VHV
,
2AA7
,
1Y9R
,
2AAX
ZINC - Investigational
MCR_HUMAN
ZINC - Metabolites
MCR_HUMAN
GeneCards
P08235
HPA
ENSG00000151623-NR3C2
Ensembl
ENSG00000151623
,
ENSP00000421481
,
ENSP00000486719
,
ENST00000512865
,
ENSP00000341390
,
ENSP00000350815
,
ENST00000625323
,
ENSP00000423510
,
ENST00000342437
,
ENST00000344721
,
ENSP00000343907
,
ENST00000511528
,
ENST00000358102
Pharos - Targets
P08235
ZINC - Predictions - Purchasable
MCR_HUMAN
Orphanet
16573
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