Translocation of Aquaporin-2 from intracellular vesicles to the apical plasma membrane

Stable Identifier
R-HSA-432237
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
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Intracellular vesicles bearing phosphorylated Aquaporin-2 tetramers are transported to the plasma membrane by a mechanism that may involve motor activity of myosin VB (inferred from rat, Nedvetsky et al. 2007) and dynein (inferred from toad bladder, Marples et al. 1996).

Literature References
PubMed ID Title Journal Year
9227644 Protein kinase A phosphorylation is involved in regulated exocytosis of aquaporin-2 in transfected LLC-PK1 cells

Katsura, T, Gustafson, CE, Ausiello, DA, Brown, D

Am J Physiol 1997
11076974 The subcellular localization of an aquaporin-2 tetramer depends on the stoichiometry of phosphorylated and nonphosphorylated monomers

Kamsteeg, EJ, Heijnen, I, van Os, CH, Deen, PM

J Cell Biol 2000
17156409 A Role of myosin Vb and Rab11-FIP2 in the aquaporin-2 shuttle

Nedvetsky, PI, Stefan, E, Frische, S, Santamaria, K, Wiesner, B, Valenti, G, Hammer JA, 3rd, Nielsen, S, Goldenring, JR, Rosenthal, W, Klussmann, E

Traffic 2007
8683474 Effect of a dynein inhibitor on vasopressin action in toad urinary bladder

Marples, D, Barber, B, Taylor, A

J Physiol 1996
12194985 The role of putative phosphorylation sites in the targeting and shuttling of the aquaporin-2 water channel

van Balkom, BW, Savelkoul, PJ, Markovich, D, Hofman, E, Nielsen, S, van der Sluijs, P, Deen, PM

J Biol Chem 2002
16120822 Lack of arginine vasopressin-induced phosphorylation of aquaporin-2 mutant AQP2-R254L explains dominant nephrogenic diabetes insipidus

de Mattia, F, Savelkoul, PJ, Kamsteeg, EJ, Konings, IB, van der Sluijs, P, Mallmann, R, Oksche, A, Deen, PM

J Am Soc Nephrol 2005
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
microfilament motor activity of MYO5B:RABFIP2:RAB11A [cytoplasmic vesicle membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created
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