Reactome | Translocation of Aquaporin-2 from intracellular vesicles to the apical plasma membrane

Translocation of Aquaporin-2 from intracellular vesicles to the apical plasma membrane

Stable Identifier

R-HSA-432237

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

plasma membrane, transport vesicle membrane

ReviewStatus

5/5

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Translocation of Aquaporin-2 from intracellular vesicles to the apical plasma membrane

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Intracellular vesicles bearing phosphorylated Aquaporin-2 tetramers are transported to the plasma membrane by a mechanism that may involve motor activity of myosin VB (inferred from rat, Nedvetsky et al. 2007) and dynein (inferred from toad bladder, Marples et al. 1996).

Literature References

PubMed ID	Title	Journal	Year
11076974	The subcellular localization of an aquaporin-2 tetramer depends on the stoichiometry of phosphorylated and nonphosphorylated monomers Kamsteeg, EJ, Heijnen, I, van Os, CH, Deen, PM	J Cell Biol	2000
9227644	Protein kinase A phosphorylation is involved in regulated exocytosis of aquaporin-2 in transfected LLC-PK1 cells Katsura, T, Gustafson, CE, Ausiello, DA, Brown, D	Am J Physiol	1997
17156409	A Role of myosin Vb and Rab11-FIP2 in the aquaporin-2 shuttle Nedvetsky, PI, Stefan, E, Frische, S, Santamaria, K, Wiesner, B, Valenti, G, Hammer JA, 3rd, Nielsen, S, Goldenring, JR, Rosenthal, W, Klussmann, E	Traffic	2007
8683474	Effect of a dynein inhibitor on vasopressin action in toad urinary bladder Marples, D, Barber, B, Taylor, A	J Physiol	1996
12194985	The role of putative phosphorylation sites in the targeting and shuttling of the aquaporin-2 water channel van Balkom, BW, Savelkoul, PJ, Markovich, D, Hofman, E, Nielsen, S, van der Sluijs, P, Deen, PM	J Biol Chem	2002
16120822	Lack of arginine vasopressin-induced phosphorylation of aquaporin-2 mutant AQP2-R254L explains dominant nephrogenic diabetes insipidus de Mattia, F, Savelkoul, PJ, Kamsteeg, EJ, Konings, IB, van der Sluijs, P, Mallmann, R, Oksche, A, Deen, PM	J Am Soc Nephrol	2005