Reactome | Aquaporin-1 passively transports water out of cell

Aquaporin-1 passively transports water out of cell

Stable Identifier

R-HSA-432054

Type

Reaction [transition]

Species

Homo sapiens

Compartment

plasma membrane, cytosol, extracellular region

ReviewStatus

5/5

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Aquaporin-1 passively transports water out of cell

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Aquaporin-1 (AQP1) passively transports water across the plasma membrane according to the osmotic gradient. In the kidney AQP1 is expressed in endothelial cells of the vasa recta, the proximal tubule, and thin descending limb of Henle, where it functions to recover water from filtrate during urine formation. AQP1 is expressed in many other tissues, such as red blood cells, pancreas, and choroid plexus. AQP1 plays a role in forming cerebrospinal fluid.

Literature References

PubMed ID	Title	Journal	Year
12801959	Distribution of aquaporin water channels AQP1 and AQP5 in the ductal system of the human pancreas Rácz, GZ, Varga, G, Steward, MC, Elkaer, ML, Burghardt, B, Kwon, TH, Nielsen, S	Gut	2003
3049610	Identification, purification, and partial characterization of a novel Mr 28,000 integral membrane protein from erythrocytes and renal tubules Kuhajda, FP, Denker, BM, Agre, P, Smith, BL	J Biol Chem	1988
14701836	Aquaporin-1, nothing but a water channel Tsunoda, SP, Wiesner, B, Lorenz, D, Rosenthal, W, Pohl, P	J Biol Chem	2004
1510932	Reconstitution of functional water channels in liposomes containing purified red cell CHIP28 protein Zeidel, ML, Ambudkar, SV, Agre, P, Smith, BL	Biochemistry	1992
9829975	Bidirectional water fluxes and specificity for small hydrophilic molecules in aquaporins 0-5 Meinild, AK, Zeuthen, T, Klaerke, DA	J Biol Chem	1998
7678419	CHIP28 water channels are localized in constitutively water-permeable segments of the nephron Knepper, MA, Christensen, EI, Nielsen, S, Agre, P, Smith, BL	J Cell Biol	1993
18202181	Mechanism of selectivity in aquaporins and aquaglyceroporins Hub, JS, de Groot, BL	Proc Natl Acad Sci U S A	2008
11034202	Structural determinants of water permeation through aquaporin-1 Heymann, JB, Hirai, T, Mitsuoka, K, Fujiyoshi, Y, Engel, A, Murata, K, Walz, T, Agre, P	Nature	2000
14592814	Expression of the AQP-1 water channel in normal human tissues: a semiquantitative study using tissue microarray technology Marples, D, Mobasheri, A	Am J Physiol Cell Physiol	2004
1373524	Appearance of water channels in Xenopus oocytes expressing red cell CHIP28 protein Preston, GM, Agre, P, Guggino, WB, Carroll, TP	Science	1992
14514735	Aquaporin expression in normal human kidney and in renal disease Walker, RJ, Bedford, JJ, Leader, JP	J Am Soc Nephrol	2003