Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA

Stable Identifier
R-HSA-428359
Type
Pathway
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA
Click the image above or here to open this pathway in the Pathway Browser
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs) bind specific sets of RNA and regulate their translation, stability, and subcellular localization. IGF2BP1, IGF2BP2, and IGF2BP3 bind about 8400 protein-coding transcripts. The target RNAs contain the sequence motif CAUH (where H is A, U, or, C) and binding of IGFBPs increases the stability of the target RNAs.
Literature References
PubMed ID Title Journal Year
9891060 A family of insulin-like growth factor II mRNA-binding proteins represses translation in late development

Nielsen, J, Wewer, UM, Christiansen, J, Johnsen, AH, Lykke-Andersen, J, Nielsen, FC

Mol Cell Biol 1999
11713986 A family of IGF-II mRNA binding proteins (IMP) involved in RNA trafficking

Nielsen, J, Christiansen, J, Nielsen, FC

Scand J Clin Lab Invest Suppl 2001
15601260 VICKZ proteins: a multi-talented family of regulatory RNA-binding proteins

Yisraeli, JK

Biol Cell 2005
17652133 VICKZ proteins mediate cell migration via their RNA binding activity

Rubinstein, AM, Maizels, Y, Oberman, F, Rand, K, Yisraeli, JK

RNA 2007
16541107 RNA-binding IMPs promote cell adhesion and invadopodia formation

Wewer, UM, Hansen, TV, Christiansen, J, Borup, R, Jønson, L, Vikesaa, J, Nielsen, FC

EMBO J 2006
20371350 Transcriptome-wide identification of RNA-binding protein and microRNA target sites by PAR-CLIP

Landthaler, M, Tuschl, T, Ulrich, A, Ascano M, Jr, Hausser, J, Khorshid, M, Dewell, S, Jungkamp, AC, Wardle, GS, Berninger, P, Munschauer, M, Burger, L, Hafner, M, Zavolan, M, Rothballer, A

Cell 2010
Participants
Events
Participates
as an event of
Event Information
Go Biological Process
regulation of mRNA stability (0043488)
Authored
May, B  (2009-07-05)
Reviewed
Chao, JA  (2010-05-30)
Singer, RH  (2010-05-30)
Created
May, B  (2009-07-05)
Cite Us!