IGF2BP1 binds specific RNAs

Stable Identifier
Reaction [binding]
Homo sapiens
Locations in the PathwayBrowser
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Insulin-like Growth Factor mRNA Binding Factor-1 (IGF2BP1, also known as ZBP1, CRD-BP, IMP1, and VICKZ1) binds several specific RNAs containing the sequence motif CAUH (where H is A, C, or U). Binding causes stabilization and subcellular localization of the RNA.
Isoforms of IGF2 mRNA containing leader-3 are bound by IGF2BP1 at the 5' UTR, repressing translation (other isoforms of IGF2 are constitutive).
ZBP1 (IGF2BP1) uses its third and fourth KH domains to recognize the first 28 nts of the 3' UTR of Beta actin mRNA. The KH domains are arranged as an anti-parallel pseudo-dimer that specifically recognize a bipartite element located in this RNA sequence.
MYC (c-MYC) and Beta-TRCP1 mRNAs are bound at sites termed Coding Region Determinants (CDRs) in the open reading frame of the message. Binding of the MYC mRNA shields it from degradation and increases its half-life
The CD44 mRNA is bound at the 3' UTR.
IGF2BP1 also binds the non-coding, imprinted H19 RNA.

Literature References
PubMed ID Title Journal Year
9891060 A family of insulin-like growth factor II mRNA-binding proteins represses translation in late development

Nielsen, J, Wewer, UM, Christiansen, J, Johnsen, AH, Lykke-Andersen, J, Nielsen, FC

Mol Cell Biol 1999
19029303 Control of c-myc mRNA stability by IGF2BP1-associated cytoplasmic RNPs

Weidensdorfer, D, Schierhorn, A, Lederer, M, Hüttelmaier, S, Köhn, M, Baude, A, Stöhr, N, Wahle, E, Buchmeier, S

RNA 2009
12894594 CRD-BP: a c-Myc mRNA stabilizing protein with an oncofetal pattern of expression

Mahaira, L, Teixeira, MR, Trangas, T, Papadopoulou, A, Dafni, U, Ioannidis, P, Pandis, N, Evangelou, E, Heim, S, Andersen, JA

Anticancer Res 2003
11713986 A family of IGF-II mRNA binding proteins (IMP) involved in RNA trafficking

Nielsen, J, Christiansen, J, Nielsen, FC

Scand J Clin Lab Invest Suppl 2001
15601260 VICKZ proteins: a multi-talented family of regulatory RNA-binding proteins

Yisraeli, JK

Biol Cell 2005
10875929 H19 RNA binds four molecules of insulin-like growth factor II mRNA-binding protein

Nielsen, J, Wewer, UM, Christiansen, J, Lykke-Andersen, J, Runge, S, Nielsen, FC

J Biol Chem 2000
16778892 CRD-BP mediates stabilization of betaTrCP1 and c-myc mRNA in response to beta-catenin signalling

Liu, J, Bhatia, N, Fuchs, SY, Elcheva, I, Spiegelman, VS, Minamoto, T, Noubissi, FK, Ougolkov, A, Shakoori, A, Ross, J

Nature 2006
20080952 ZBP1 recognition of beta-actin zipcode induces RNA looping

Singer, RH, Levy, M, Almo, SC, Patel, V, Chao, JA, Patskovsky, Y

Genes Dev 2010
17652133 VICKZ proteins mediate cell migration via their RNA binding activity

Rubinstein, AM, Maizels, Y, Oberman, F, Rand, K, Yisraeli, JK

RNA 2007
16541107 RNA-binding IMPs promote cell adhesion and invadopodia formation

Wewer, UM, Hansen, TV, Christiansen, J, Borup, R, Jønson, L, Vikesaa, J, Nielsen, FC

EMBO J 2006
20371350 Transcriptome-wide identification of RNA-binding protein and microRNA target sites by PAR-CLIP

Landthaler, M, Tuschl, T, Ulrich, A, Ascano M, Jr, Hausser, J, Khorshid, M, Dewell, S, Jungkamp, AC, Wardle, GS, Berninger, P, Munschauer, M, Burger, L, Hafner, M, Zavolan, M, Rothballer, A

Cell 2010
12024010 Regulation of c-myc mRNA decay by translational pausing in a coding region instability determinant

Lemm, I, Ross, J

Mol Cell Biol 2002
Cite Us!