IGF2BP2 binds specific RNAs

Stable Identifier
R-HSA-428293
Type
Reaction [binding]
Species
Homo sapiens
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Insulin-like Growth Factor mRNA Binding Factor-2 (IGF2BP2, also known as IMP2 and VICKZ2) binds several specific RNAs containing the sequence motif CAUH (where H is A, C, or U). Binding causes stabilization and subcellular localization of the RNA.
Isoforms of IGF2 mRNA containing leader-3 are bound by IGF2BP2 at the 5' UTR, repressing translation (Other isoforms of IGF2 are constitutive).
IGF2BP2 may be a causal factor in type 2 diabetes.

Literature References
PubMed ID Title Journal Year
11713986 A family of IGF-II mRNA binding proteins (IMP) involved in RNA trafficking

Nielsen, FC, Nielsen, J, Christiansen, J

Scand J Clin Lab Invest Suppl 2001
9891060 A family of insulin-like growth factor II mRNA-binding proteins represses translation in late development

Nielsen, J, Christiansen, J, Lykke-Andersen, J, Johnsen, AH, Wewer, UM, Nielsen, FC

Mol Cell Biol 1999
15601260 VICKZ proteins: a multi-talented family of regulatory RNA-binding proteins

Yisraeli, JK

Biol Cell 2005
18618095 Variants of CDKAL1 and IGF2BP2 affect first-phase insulin secretion during hyperglycaemic clamps

Groenewoud, MJ, Dekker, JM, Fritsche, A, Reiling, E, Nijpels, G, Heine, RJ, Maassen, JA, Machicao, F, Schäfer, SA, Häring, HU, 't Hart, LM, van Haeften, TW

Diabetologia 2008
19429674 IGF2 mRNA-binding protein 2 - biological function and putative role in type 2 diabetes

Christiansen, J, Kolte, A, Hansen, T, Nielsen, F

J Mol Endocrinol 2009
20371350 Transcriptome-wide identification of RNA-binding protein and microRNA target sites by PAR-CLIP

Hafner, M, Landthaler, M, Burger, L, Khorshid, M, Hausser, J, Berninger, P, Rothballer, A, Ascano M, Jr, Jungkamp, AC, Munschauer, M, Ulrich, A, Wardle, GS, Dewell, S, Zavolan, M, Tuschl, T

Cell 2010
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