Type II Na+/Pi cotransporters

Stable Identifier
R-HSA-427589
Type
Pathway
Species
Homo sapiens
ReviewStatus
5/5
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Type II Na+/Pi cotransporters
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The SLC34 family of type II Na+/Pi cotransporters consist of three members; NaPi-IIa (SLC34A1), NaPi-IIb (SLC34A2) and NaPi-IIc (SLC34A3) (Murer H et al, 2004). They are expressed mainly in the kidney and small intestine, located at the apical sites of epithelial cells although other areas of the body express them to a lesser extent. NaPi-IIa and b cotransports divalent Pi (HPO4[2-]) with three Na+ ions (electrogenic transport) whereas NaPi-IIc cotransports divalent Pi with two Na+ ions (electroneutral transport).
Literature References
PubMed ID Title Journal Year
12750889 The sodium phosphate cotransporter family SLC34

Biber, J, Murer, H, Forster, I

Pflugers Arch 2004
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Orthologous Events
Type II Na+/Pi cotransporters (Bos taurus)
Type II Na+/Pi cotransporters (Caenorhabditis elegans)
Type II Na+/Pi cotransporters (Canis familiaris)
Type II Na+/Pi cotransporters (Danio rerio)
Type II Na+/Pi cotransporters (Gallus gallus)
Type II Na+/Pi cotransporters (Mus musculus)
Type II Na+/Pi cotransporters (Rattus norvegicus)
Type II Na+/Pi cotransporters (Sus scrofa)
Type II Na+/Pi cotransporters (Xenopus tropicalis)
Cross References
BioModels Database
Authored
Jassal, B  (2009-06-23)
Reviewed
He, L  (2009-08-24)
Created
Jassal, B  (2009-06-23)
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