Reactome | Sodium-coupled phosphate cotransporters

Sodium-coupled phosphate cotransporters

Stable Identifier

R-HSA-427652

Type

Pathway

Species

Homo sapiens

ReviewStatus

5/5

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Phosphorus is an essential element that is critical for structural and metabolic roles in all living organisms. Cells obtain phosphorus in the form of negatively-charged inorganic phosphate (Pi). Two SLC families transport phosphate in mammals; SLC34 (Murer H et al, 2004) and SLC20 (Collins JF et al, 2004). Both are secondary-active, Na+-coupled transporter systems which use the inward Na+ gradient (from the Na+-K+-ATPase) to drive phosphate influx into cells (Virkki LV et al, 2007).

Literature References

PubMed ID	Title	Journal	Year
12750889	The sodium phosphate cotransporter family SLC34 Biber, J, Murer, H, Forster, I	Pflugers Arch	2004
17581921	Phosphate transporters: a tale of two solute carrier families Virkki, LV, Forster, IC, Biber, J, Murer, H	Am J Physiol Renal Physiol	2007
12759754	The SLC20 family of proteins: dual functions as sodium-phosphate cotransporters and viral receptors Bai, L, Ghishan, FK, Collins, JF	Pflugers Arch	2004