eNoSC dimethylates histone H3 at lysine-9

Stable Identifier
R-HSA-427527
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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eNoSC dimethylates histone H3 at lysine-9
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The SUV39H1 component of eNoSC dimethylates histone H3 at lysine-9 (Murayama et al. 2008). The reaction depends on the prior deacetylation reaction catalyzed by the SIRT1 component of eNoSC. Histone H3 dimethylated at lysine-9 inhibits expression of rRNA genes.
Literature References
PubMed ID Title Journal Year
18485871 Epigenetic control of rDNA loci in response to intracellular energy status

Fujimura, A, Murayama, A, Minami, H, Nagata, K, Kuroda, T, Kimura, K, Oie, S, Ohmori, K, Yasuzawa-Tanaka, K, Daitoku, H, Yanagisawa, J, Fukamizu, A, Okuwaki, M, Shimizu, T

Cell 2008
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Catalyst Activity

histone H3K9 methyltransferase activity of eNoSC [nucleoplasm]

Physical Entity
eNoSC [nucleoplasm] (Homo sapiens)
Activity
histone H3K9 methyltransferase activity (GO:0046974)
Orthologous Events
eNoSC dimethylates histone H3 at lysine-9 (Bos taurus)
eNoSC dimethylates histone H3 at lysine-9 (Canis familiaris)
eNoSC dimethylates histone H3 at lysine-9 (Dictyostelium discoideum)
eNoSC dimethylates histone H3 at lysine-9 (Drosophila melanogaster)
eNoSC dimethylates histone H3 at lysine-9 (Rattus norvegicus)
eNoSC dimethylates histone H3 at lysine-9 (Saccharomyces cerevisiae)
eNoSC dimethylates histone H3 at lysine-9 (Schizosaccharomyces pombe)
eNoSC dimethylates histone H3 at lysine-9 (Sus scrofa)
Authored
May, B  (2009-06-22)
Reviewed
Voit, R  (2014-01-21)
Grummt, I  (2014-01-21)
Created
May, B  (2009-06-23)
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