Reactome | ST8SIA4 [Golgi membrane]

ST8SIA4 [Golgi membrane]

Stable Identifier

R-HSA-422390

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

Golgi membrane

Synonyms

PST (ST8SIA4), CMP-N-acetylneuraminate-poly-alpha-2,8-sialyltransferase, SIA8D_HUMAN

Locations in the PathwayBrowser

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Developmental Biology (Homo sapiens)

- Nervous system development (Homo sapiens)
  - Axon guidance (Homo sapiens)
    - NCAM signaling for neurite out-growth (Homo sapiens)
      - NCAM1 interactions (Homo sapiens)
        
        Polysialylation of NCAM1 (Homo sapiens)
        
        alpha 2-8 polysialyltransferases [Golgi membrane] (Homo sapiens)
        
        ST8SIA4 [Golgi membrane] (Homo sapiens)

Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - Asparagine N-linked glycosylation (Homo sapiens)
    - Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein (Homo sapiens)
      - Synthesis of substrates in N-glycan biosythesis (Homo sapiens)
        
        Sialic acid metabolism (Homo sapiens)
        
        ST8SIA1-6 transfer Neu5Ac to terminal Neu5Ac residues (Homo sapiens)
        
        ST8SIA1-6 [Golgi membrane] (Homo sapiens)
        
        ST8SIA4 [Golgi membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q92187 ST8SIA4

Gene Names

ST8SIA4, PST, PST1, SIAT8D

Chain

chain:1-359

Reference Genes

BioGPS Gene:7903 ST8SIA4

COSMIC (genes):ST8SIA4 ST8SIA4

CTD Gene:7903 ST8SIA4

dbSNP Gene:7903 ST8SIA4

ENSEMBL:ENSG00000113532.13 ST8SIA4

HGNC:10871 ST8SIA4

KEGG Gene (Homo sapiens):7903 ST8SIA4

Monarch:7903 ST8SIA4

NCBI Gene:7903 ST8SIA4

OMIM:602547 ST8SIA4

UCSC:Q92187 ST8SIA4

Reference Transcript

Other Identifiers

11737405_at

11739521_at

11739522_at

11739523_at

1554460_PM_at

1554460_at

16998532

206925_PM_at

206925_at

230261_PM_at

230261_at

230836_PM_at

230836_at

242943_PM_at

242943_at

2868909

2868910

2868911

2868912

2868913

2868914

2868915

2868916

2868917

2868918

2868938

2868939

2868940

2868943

2868944

2868946

2868951

2868952

2868953

2868954

2868955

33649_at

44207_at

46175_i_at

46176_r_at

7903

80847_at

8113358

A_23_P361984

A_23_P435601

A_33_P3291484

GE57768

GO:0000139

GO:0001574

GO:0003824

GO:0003828

GO:0005794

GO:0005975

GO:0006486

GO:0006491

GO:0006629

GO:0007399

GO:0008373

GO:0009311

GO:0016020

GO:0016740

GO:0016757

GO:0033691

GO:0036211

GO:0043226

GO:0048856

GO:0097503

GO:1901135

HMNXSV003002210

Hs.152049.0.S1_3p_at

Hs.218289.0.A1_3p_at

Hs.61385.0.A1_3p_at

Hs2.170180.2.S1_3p_at

ILMN_1689846

ILMN_1756937

ILMN_2253732

ILMN_2394161

L41680_at

PH_hs_0029716

TC05001638.hg

g5031998_3p_at

Participates

as a member of

Inferred To

ST8SIA4 [Golgi membrane] (Bos taurus)

ST8SIA4 [Golgi membrane] (Canis familiaris)

ST8SIA4 [Golgi membrane] (Gallus gallus)

ST8SIA4 [Golgi membrane] (Mus musculus)

ST8SIA4 [Golgi membrane] (Sus scrofa)

st8sia4 [Golgi membrane] (Xenopus tropicalis)

pst [Golgi membrane] (Danio rerio)

St8sia4 [Golgi membrane] (Rattus norvegicus)

Cross References

RefSeq

NP_778222.1, NP_005659.1

OpenTargets

ENSG00000113532

HPA

ENSG00000113532-ST8SIA4

GeneCards

Q92187

Ensembl

ENSG00000113532, ENSP00000231461, ENST00000451528, ENST00000231461, ENSP00000428914

PRO

Q92187

Pharos - Targets

Q92187

HMDB Protein

HMDBP14324

PDB

5Y22, 6AHZ, 5Y3U