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GABBR1 [plasma membrane]
Stable Identifier
R-HSA-420716
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Gamma-aminobutyric acid type B receptor subunit 1, GABR1_HUMAN
Locations in the PathwayBrowser
Expand all
Neuronal System (Homo sapiens)
Potassium Channels (Homo sapiens)
Inwardly rectifying K+ channels (Homo sapiens)
G protein gated Potassium channels (Homo sapiens)
Activation of G protein gated Potassium channels (Homo sapiens)
Activation of GIRK/Kir3 Channels (Homo sapiens)
GABA B receptor G-protein beta-gamma and Kir3 channel complex [plasma membrane] (Homo sapiens)
GABA B receptor G-protein beta-gamma complex [plasma membrane] (Homo sapiens)
GABBR1:GABBR2:GABA [plasma membrane] (Homo sapiens)
GABBR1:GABBR2 [plasma membrane] (Homo sapiens)
GABBR1 [plasma membrane] (Homo sapiens)
Association of GABA B receptor with G protein beta-gamma subunits (Homo sapiens)
GABA B receptor G-protein beta-gamma complex [plasma membrane] (Homo sapiens)
GABBR1:GABBR2:GABA [plasma membrane] (Homo sapiens)
GABBR1:GABBR2 [plasma membrane] (Homo sapiens)
GABBR1 [plasma membrane] (Homo sapiens)
GABBR1:GABBR2:GABA [plasma membrane] (Homo sapiens)
GABBR1:GABBR2 [plasma membrane] (Homo sapiens)
GABBR1 [plasma membrane] (Homo sapiens)
Binding of Gbeta/gamma to GIRK/Kir3 channels (Homo sapiens)
GABA B receptor G-protein beta-gamma and Kir3 channel complex [plasma membrane] (Homo sapiens)
GABA B receptor G-protein beta-gamma complex [plasma membrane] (Homo sapiens)
GABBR1:GABBR2:GABA [plasma membrane] (Homo sapiens)
GABBR1:GABBR2 [plasma membrane] (Homo sapiens)
GABBR1 [plasma membrane] (Homo sapiens)
GABA B receptor G-protein beta-gamma complex [plasma membrane] (Homo sapiens)
GABBR1:GABBR2:GABA [plasma membrane] (Homo sapiens)
GABBR1:GABBR2 [plasma membrane] (Homo sapiens)
GABBR1 [plasma membrane] (Homo sapiens)
GABBR1:GABBR2:GABA [plasma membrane] (Homo sapiens)
GABBR1:GABBR2 [plasma membrane] (Homo sapiens)
GABBR1 [plasma membrane] (Homo sapiens)
Transmission across Chemical Synapses (Homo sapiens)
Neurotransmitter receptors and postsynaptic signal transmission (Homo sapiens)
GABA receptor activation (Homo sapiens)
GABA B receptor activation (Homo sapiens)
Activation of GABAB receptors (Homo sapiens)
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits (Homo sapiens)
Activation of GIRK/Kir3 Channels (Homo sapiens)
GABA B receptor G-protein beta-gamma and Kir3 channel complex [plasma membrane] (Homo sapiens)
GABA B receptor G-protein beta-gamma complex [plasma membrane] (Homo sapiens)
GABBR1:GABBR2:GABA [plasma membrane] (Homo sapiens)
GABBR1:GABBR2 [plasma membrane] (Homo sapiens)
GABBR1 [plasma membrane] (Homo sapiens)
Association of GABA B receptor with G protein beta-gamma subunits (Homo sapiens)
GABA B receptor G-protein beta-gamma complex [plasma membrane] (Homo sapiens)
GABBR1:GABBR2:GABA [plasma membrane] (Homo sapiens)
GABBR1:GABBR2 [plasma membrane] (Homo sapiens)
GABBR1 [plasma membrane] (Homo sapiens)
GABBR1:GABBR2:GABA [plasma membrane] (Homo sapiens)
GABBR1:GABBR2 [plasma membrane] (Homo sapiens)
GABBR1 [plasma membrane] (Homo sapiens)
Binding of Gbeta/gamma to GIRK/Kir3 channels (Homo sapiens)
GABA B receptor G-protein beta-gamma and Kir3 channel complex [plasma membrane] (Homo sapiens)
GABA B receptor G-protein beta-gamma complex [plasma membrane] (Homo sapiens)
GABBR1:GABBR2:GABA [plasma membrane] (Homo sapiens)
GABBR1:GABBR2 [plasma membrane] (Homo sapiens)
GABBR1 [plasma membrane] (Homo sapiens)
GABA B receptor G-protein beta-gamma complex [plasma membrane] (Homo sapiens)
GABBR1:GABBR2:GABA [plasma membrane] (Homo sapiens)
GABBR1:GABBR2 [plasma membrane] (Homo sapiens)
GABBR1 [plasma membrane] (Homo sapiens)
GABBR1:GABBR2:GABA [plasma membrane] (Homo sapiens)
GABBR1:GABBR2 [plasma membrane] (Homo sapiens)
GABBR1 [plasma membrane] (Homo sapiens)
GABAB heterodimeric receptor binds GABA (Homo sapiens)
GABBR1:GABBR2 [plasma membrane] (Homo sapiens)
GABBR1 [plasma membrane] (Homo sapiens)
GABBR1:GABBR2:GABA [plasma membrane] (Homo sapiens)
GABBR1:GABBR2 [plasma membrane] (Homo sapiens)
GABBR1 [plasma membrane] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (i) signalling events (Homo sapiens)
Liganded Gi-activating GPCR acts as a GEF for Gi (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
GABBR1:GABBR2:GABA [plasma membrane] (Homo sapiens)
GABBR1:GABBR2 [plasma membrane] (Homo sapiens)
GABBR1 [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
GABBR1:GABBR2:GABA [plasma membrane] (Homo sapiens)
GABBR1:GABBR2 [plasma membrane] (Homo sapiens)
GABBR1 [plasma membrane] (Homo sapiens)
Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
GABBR1:GABBR2:GABA [plasma membrane] (Homo sapiens)
GABBR1:GABBR2 [plasma membrane] (Homo sapiens)
GABBR1 [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
GABBR1:GABBR2:GABA [plasma membrane] (Homo sapiens)
GABBR1:GABBR2 [plasma membrane] (Homo sapiens)
GABBR1 [plasma membrane] (Homo sapiens)
The Ligand:GPCR:Gi complex dissociates (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
GABBR1:GABBR2:GABA [plasma membrane] (Homo sapiens)
GABBR1:GABBR2 [plasma membrane] (Homo sapiens)
GABBR1 [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
GABBR1:GABBR2:GABA [plasma membrane] (Homo sapiens)
GABBR1:GABBR2 [plasma membrane] (Homo sapiens)
GABBR1 [plasma membrane] (Homo sapiens)
GPCR ligand binding (Homo sapiens)
Class C/3 (Metabotropic glutamate/pheromone receptors) (Homo sapiens)
GABAB heterodimeric receptor binds GABA (Homo sapiens)
GABBR1:GABBR2 [plasma membrane] (Homo sapiens)
GABBR1 [plasma membrane] (Homo sapiens)
GABBR1:GABBR2:GABA [plasma membrane] (Homo sapiens)
GABBR1:GABBR2 [plasma membrane] (Homo sapiens)
GABBR1 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9UBS5 GABBR1
Gene Names
GABBR1, GPRC3A
Chain
signal peptide:1-19, chain:20-961
Reference Genes
BioGPS Gene:2550 GABBR1
COSMIC (genes):GABBR1 GABBR1
CTD Gene:2550 GABBR1
dbSNP Gene:2550 GABBR1
ENSEMBL:ENSG00000204681 GABBR1
ENSEMBL_homo_sapiens_GENE:ENSG00000204681.11 GABBR1
ENSEMBL_homo_sapiens_GENE:ENSG00000206466.10 GABBR1
ENSEMBL_homo_sapiens_GENE:ENSG00000206511.10 GABBR1
ENSEMBL_homo_sapiens_GENE:ENSG00000232569.8 GABBR1
ENSEMBL_homo_sapiens_GENE:ENSG00000232632.8 GABBR1
ENSEMBL_homo_sapiens_GENE:ENSG00000237051.8 GABBR1
ENSEMBL_homo_sapiens_GENE:ENSG00000237112.8 GABBR1
HGNC:4070 GABBR1
KEGG Gene (Homo sapiens):2550 GABBR1
Monarch:2550 GABBR1
NCBI Gene:2550 GABBR1
OMIM:603540 GABBR1
UCSC:Q9UBS5 GABBR1
Reference Transcript
RefSeq:NM_001319053.1 GABBR1
RefSeq:NM_021903.2 GABBR1
RefSeq:NM_001470.3 GABBR1
RefSeq:NM_021904.3 GABBR1
Other Identifiers
11721552_a_at
11721553_a_at
11723069_at
11730725_a_at
17016692
17016697
17026529
17028593
17031373
17031378
17033830
17036121
17038872
203146_PM_s_at
203146_s_at
205890_PM_s_at
205890_s_at
2550
2947878
2947879
2947880
2947892
2947893
2947894
2947895
2947896
2947897
2947898
2947899
2947900
2947901
2947902
2947903
2947906
2947908
2947912
2947913
2947916
2947917
2947919
2947921
2947922
2947923
2947926
2947928
2947929
2947930
2947931
2947933
2947934
2947935
2947941
2947942
2947943
2947944
2947946
32623_at
3874226
39959_at
8124654
8178298
8179595
82572_at
86077_i_at
A_23_P81898
A_23_P93302
A_33_P3343493
GE55257
GE60282
GE80384
GO:0001649
GO:0004930
GO:0004965
GO:0005515
GO:0005576
GO:0005615
GO:0005737
GO:0005739
GO:0005783
GO:0005789
GO:0005886
GO:0007165
GO:0007186
GO:0007193
GO:0007214
GO:0008021
GO:0008285
GO:0014048
GO:0014049
GO:0014053
GO:0016020
GO:0023052
GO:0030154
GO:0030425
GO:0030673
GO:0031410
GO:0031966
GO:0032811
GO:0033602
GO:0035094
GO:0038037
GO:0038039
GO:0042734
GO:0042995
GO:0043025
GO:0043197
GO:0043198
GO:0043226
GO:0045202
GO:0045211
GO:0045471
GO:0046982
GO:0050805
GO:0050896
GO:0051932
GO:0060078
GO:0060089
GO:0060124
GO:0097060
GO:0098685
GO:0098793
GO:0098978
GO:0098982
GO:0099505
GO:0099579
GO:0150047
GO:0150099
GO:1902710
GO:1902712
GO:1990430
HMNXSV003033652
HMNXSV003033878
HMNXSV003054705
ILMN_1658965
ILMN_1678841
ILMN_2395373
ILMN_2395375
PH_hs_0010040
TC06004112.hg
TC6_apd_hap1000125.hg
TC6_cox_hap2000248.hg
TC6_dbb_hap3000227.hg
TC6_mann_hap4000197.hg
TC6_mcf_hap5000214.hg
TC6_qbl_hap6000226.hg
g10835014_3p_a_at
g5454143_3p_a_at
Participates
as a component of
GABBR1:GABBR2 [plasma membrane] (Homo sapiens)
Inferred To
gbb-1 [plasma membrane]
(Caenorhabditis elegans)
GABBR1 [plasma membrane]
(Bos taurus)
GABBR1 [plasma membrane]
(Canis familiaris)
GABBR1 [plasma membrane]
(Gallus gallus)
GABBR1 [plasma membrane]
(Mus musculus)
GABBR1 [plasma membrane]
(Rattus norvegicus)
GABBR1 [plasma membrane]
(Sus scrofa)
Homologues of GABBR1 [plasma membrane]
(Dictyostelium discoideum)
Ghost homologue of GABBR1 [plasma membrane]
(Xenopus tropicalis)
grlE [plasma membrane]
(Dictyostelium discoideum)
grlP [plasma membrane]
(Dictyostelium discoideum)
grlQ [plasma membrane]
(Dictyostelium discoideum)
GABA-B-R1 [plasma membrane]
(Drosophila melanogaster)
Cross References
RefSeq
NP_068703.1
,
NP_001461.1
,
NP_001305982.1
,
NP_068704.2
ZINC - World Drugs
GABR1_HUMAN
Guide to Pharmacology - Targets
240
OpenTargets
ENSG00000204681
ZINC - FDA approved
GABR1_HUMAN
ZINC - Substances
GABR1_HUMAN
ZINC - Biogenic
GABR1_HUMAN
ZINC target
Q9UBS5
PRO
Q9UBS5
PDB
6W2Y
,
4MS4
,
6W2X
,
4PAS
,
7EB2
,
4MQE
,
6UO9
,
4MR7
,
7C7Q
,
6UO8
,
4MR8
,
4MQF
,
4MRM
,
7CA3
,
6VJM
,
6WIV
,
7CA5
,
7C7S
,
4MR9
,
6UOA
,
6HKC
,
4MS1
,
7CUM
,
4MS3
ZINC - Metabolites
GABR1_HUMAN
GeneCards
Q9UBS5
HPA
ENSG00000204681-GABBR1
Ensembl
ENSP00000408938
,
ENSP00000411263
,
ENSG00000204681
,
ENSP00000366211
,
ENSP00000366215
,
ENSP00000373029
,
ENSP00000449449
,
ENST00000419674
,
ENSP00000391572
,
ENST00000452300
,
ENSP00000373132
,
ENSP00000399861
,
ENST00000494877
,
ENSP00000516435
,
ENSP00000388035
,
ENSG00000206511
,
ENST00000425097
,
ENST00000552399
,
ENSP00000419755
,
ENSP00000373135
,
ENST00000449163
,
ENSP00000373133
,
ENSP00000448531
,
ENSP00000448654
,
ENST00000548767
,
ENST00000377034
,
ENST00000706533
,
ENSP00000348248
,
ENSP00000406499
,
ENST00000546913
,
ENSP00000406285
,
ENST00000439457
,
ENST00000383542
,
ENSP00000399318
,
ENST00000377012
,
ENSP00000419061
,
ENST00000383638
,
ENST00000434660
,
ENST00000383637
,
ENSG00000237112
,
ENST00000462632
,
ENST00000547410
,
ENST00000355973
,
ENSP00000394528
,
ENST00000446436
,
ENSP00000446983
,
ENSP00000448999
,
ENSG00000206466
,
ENST00000458612
,
ENSP00000406066
,
ENST00000551140
,
ENSP00000416903
,
ENSP00000373033
,
ENST00000443440
,
ENST00000383537
,
ENST00000438094
,
ENST00000551423
,
ENSP00000449342
,
ENSP00000373134
,
ENSP00000412167
,
ENSG00000237051
,
ENSG00000232632
,
ENSP00000405709
,
ENSP00000366233
,
ENST00000414980
,
ENST00000448754
,
ENSG00000232569
,
ENST00000423604
,
ENST00000377016
,
ENSP00000373035
,
ENST00000383541
,
ENST00000383543
,
ENSP00000373034
,
ENST00000417759
,
ENSP00000411286
,
ENST00000383639
,
ENST00000383636
Pharos - Targets
Q9UBS5
Orphanet
28458
ZINC - Predictions - Purchasable
GABR1_HUMAN
HMDB Protein
HMDBP02330
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P46459 NSF
1
NSF [cytosol]
(R-HSA-264471)
0.571
3
UniProt:O15354 GPR37
1
GPR37 [plasma membrane]
(R-HSA-5333623)
0.508
2
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