Reactome | GABBR1 [plasma membrane]

GABBR1 [plasma membrane]

Stable Identifier

R-CFA-420716

Type

Protein [EntityWithAccessionedSequence]

Species

Canis familiaris

Compartment

plasma membrane

Synonyms

GABBR1, A0A8I3PDF9

Locations in the PathwayBrowser

Expand all

Neuronal System (Canis familiaris)

- Potassium Channels (Canis familiaris)
  - Inwardly rectifying K+ channels (Canis familiaris)
    - G protein gated Potassium channels (Canis familiaris)
      - Activation of G protein gated Potassium channels (Canis familiaris)
        
        Activation of GIRK/Kir3 Channels (Canis familiaris)
        
        GABA B receptor G-protein beta-gamma and Kir3 channel complex [plasma membrane] (Canis familiaris)
        
        GABA B receptor G-protein beta-gamma complex [plasma membrane] (Canis familiaris)
        
        GABBR1:GABBR2:GABA [plasma membrane] (Canis familiaris)
        
        GABBR1:GABBR2 [plasma membrane] (Canis familiaris)
        
        GABBR1 [plasma membrane] (Canis familiaris)
        
        Association of GABA B receptor with G protein beta-gamma subunits (Canis familiaris)
        
        GABA B receptor G-protein beta-gamma complex [plasma membrane] (Canis familiaris)
        
        GABBR1:GABBR2:GABA [plasma membrane] (Canis familiaris)
        
        GABBR1:GABBR2 [plasma membrane] (Canis familiaris)
        
        GABBR1 [plasma membrane] (Canis familiaris)
        
        GABBR1:GABBR2:GABA [plasma membrane] (Canis familiaris)
        
        GABBR1:GABBR2 [plasma membrane] (Canis familiaris)
        
        GABBR1 [plasma membrane] (Canis familiaris)
        
        Binding of Gbeta/gamma to GIRK/Kir3 channels (Canis familiaris)
        
        GABA B receptor G-protein beta-gamma and Kir3 channel complex [plasma membrane] (Canis familiaris)
        
        GABA B receptor G-protein beta-gamma complex [plasma membrane] (Canis familiaris)
        
        GABBR1:GABBR2:GABA [plasma membrane] (Canis familiaris)
        
        GABBR1:GABBR2 [plasma membrane] (Canis familiaris)
        
        GABBR1 [plasma membrane] (Canis familiaris)
        
        GABA B receptor G-protein beta-gamma complex [plasma membrane] (Canis familiaris)
        
        GABBR1:GABBR2:GABA [plasma membrane] (Canis familiaris)
        
        GABBR1:GABBR2 [plasma membrane] (Canis familiaris)
        
        GABBR1 [plasma membrane] (Canis familiaris)
        
        GABBR1:GABBR2:GABA [plasma membrane] (Canis familiaris)
        
        GABBR1:GABBR2 [plasma membrane] (Canis familiaris)
        
        GABBR1 [plasma membrane] (Canis familiaris)
- Transmission across Chemical Synapses (Canis familiaris)
  - Neurotransmitter receptors and postsynaptic signal transmission (Canis familiaris)
    - GABA receptor activation (Canis familiaris)
      - GABA B receptor activation (Canis familiaris)
        
        Activation of GABAB receptors (Canis familiaris)
        
        Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits (Canis familiaris)
        
        Activation of GIRK/Kir3 Channels (Canis familiaris)
        
        GABA B receptor G-protein beta-gamma and Kir3 channel complex [plasma membrane] (Canis familiaris)
        
        GABA B receptor G-protein beta-gamma complex [plasma membrane] (Canis familiaris)
        
        GABBR1:GABBR2:GABA [plasma membrane] (Canis familiaris)
        
        GABBR1:GABBR2 [plasma membrane] (Canis familiaris)
        
        GABBR1 [plasma membrane] (Canis familiaris)
        
        Association of GABA B receptor with G protein beta-gamma subunits (Canis familiaris)
        
        GABA B receptor G-protein beta-gamma complex [plasma membrane] (Canis familiaris)
        
        GABBR1:GABBR2:GABA [plasma membrane] (Canis familiaris)
        
        GABBR1:GABBR2 [plasma membrane] (Canis familiaris)
        
        GABBR1 [plasma membrane] (Canis familiaris)
        
        GABBR1:GABBR2:GABA [plasma membrane] (Canis familiaris)
        
        GABBR1:GABBR2 [plasma membrane] (Canis familiaris)
        
        GABBR1 [plasma membrane] (Canis familiaris)
        
        Binding of Gbeta/gamma to GIRK/Kir3 channels (Canis familiaris)
        
        GABA B receptor G-protein beta-gamma and Kir3 channel complex [plasma membrane] (Canis familiaris)
        
        GABA B receptor G-protein beta-gamma complex [plasma membrane] (Canis familiaris)
        
        GABBR1:GABBR2:GABA [plasma membrane] (Canis familiaris)
        
        GABBR1:GABBR2 [plasma membrane] (Canis familiaris)
        
        GABBR1 [plasma membrane] (Canis familiaris)
        
        GABA B receptor G-protein beta-gamma complex [plasma membrane] (Canis familiaris)
        
        GABBR1:GABBR2:GABA [plasma membrane] (Canis familiaris)
        
        GABBR1:GABBR2 [plasma membrane] (Canis familiaris)
        
        GABBR1 [plasma membrane] (Canis familiaris)
        
        GABBR1:GABBR2:GABA [plasma membrane] (Canis familiaris)
        
        GABBR1:GABBR2 [plasma membrane] (Canis familiaris)
        
        GABBR1 [plasma membrane] (Canis familiaris)
        
        GABAB heterodimeric receptor binds GABA (Canis familiaris)
        
        GABBR1:GABBR2 [plasma membrane] (Canis familiaris)
        
        GABBR1 [plasma membrane] (Canis familiaris)
        
        GABBR1:GABBR2:GABA [plasma membrane] (Canis familiaris)
        
        GABBR1:GABBR2 [plasma membrane] (Canis familiaris)
        
        GABBR1 [plasma membrane] (Canis familiaris)

Signal Transduction (Canis familiaris)

- Signaling by GPCR (Canis familiaris)
  - GPCR downstream signalling (Canis familiaris)
    - G alpha (i) signalling events (Canis familiaris)
      - Liganded Gi-activating GPCR acts as a GEF for Gi (Canis familiaris)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Canis familiaris)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Canis familiaris)
        
        GABBR1:GABBR2:GABA [plasma membrane] (Canis familiaris)
        
        GABBR1:GABBR2 [plasma membrane] (Canis familiaris)
        
        GABBR1 [plasma membrane] (Canis familiaris)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Canis familiaris)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Canis familiaris)
        
        GABBR1:GABBR2:GABA [plasma membrane] (Canis familiaris)
        
        GABBR1:GABBR2 [plasma membrane] (Canis familiaris)
        
        GABBR1 [plasma membrane] (Canis familiaris)
      - Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Canis familiaris)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Canis familiaris)
        
        GABBR1:GABBR2:GABA [plasma membrane] (Canis familiaris)
        
        GABBR1:GABBR2 [plasma membrane] (Canis familiaris)
        
        GABBR1 [plasma membrane] (Canis familiaris)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Canis familiaris)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Canis familiaris)
        
        GABBR1:GABBR2:GABA [plasma membrane] (Canis familiaris)
        
        GABBR1:GABBR2 [plasma membrane] (Canis familiaris)
        
        GABBR1 [plasma membrane] (Canis familiaris)
      - The Ligand:GPCR:Gi complex dissociates (Canis familiaris)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Canis familiaris)
        
        GABBR1:GABBR2:GABA [plasma membrane] (Canis familiaris)
        
        GABBR1:GABBR2 [plasma membrane] (Canis familiaris)
        
        GABBR1 [plasma membrane] (Canis familiaris)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Canis familiaris)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Canis familiaris)
        
        GABBR1:GABBR2:GABA [plasma membrane] (Canis familiaris)
        
        GABBR1:GABBR2 [plasma membrane] (Canis familiaris)
        
        GABBR1 [plasma membrane] (Canis familiaris)
  - GPCR ligand binding (Canis familiaris)
    - Class C/3 (Metabotropic glutamate/pheromone receptors) (Canis familiaris)
      - GABAB heterodimeric receptor binds GABA (Canis familiaris)
        
        GABBR1:GABBR2 [plasma membrane] (Canis familiaris)
        
        GABBR1 [plasma membrane] (Canis familiaris)
        
        GABBR1:GABBR2:GABA [plasma membrane] (Canis familiaris)
        
        GABBR1:GABBR2 [plasma membrane] (Canis familiaris)
        
        GABBR1 [plasma membrane] (Canis familiaris)

External Reference Information

External Reference

UniProt:A0A8I3PDF9

Gene Names

GABBR1

Reference Genes

ENSEMBL:ENSCAFG00845018375.1

ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00845018375.1 GABBR1

Other Identifiers

488340

CfaAffx.18916.1.S1_s_at

GO:0004930

GO:0004965

GO:0005737

GO:0005886

GO:0007165

GO:0007186

GO:0007193

GO:0007214

GO:0016020

GO:0023052

GO:0038037

GO:0038039

GO:0042734

GO:0045211

GO:0060078

GO:0060089

GO:0098685

GO:0098793

GO:0098982

GO:0099505

GO:0099579

GO:0110165

GO:0150047

GO:1902712

Participates

as a component of

GABBR1:GABBR2 [plasma membrane] (Canis familiaris)

Inferred From

GABBR1 [plasma membrane] (Homo sapiens)

Cross References

OpenTargets

ENSG00000204681

Ensembl

ENSCAFP00845025450, ENSCAFG00845018375, ENSCAFT00845032545

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