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GRM1 [plasma membrane]
Stable Identifier
R-HSA-420521
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Metabotropic glutamate receptor 1, GRM1_HUMAN
Locations in the PathwayBrowser
Expand all
Neuronal System (Homo sapiens)
Protein-protein interactions at synapses (Homo sapiens)
Neurexins and neuroligins (Homo sapiens)
HOMER binds SHANK proteins (Homo sapiens)
2xHOMER1,2,3:GRM1,GRM5 [plasma membrane] (Homo sapiens)
GRM1,GRM5 [plasma membrane] (Homo sapiens)
GRM1 [plasma membrane] (Homo sapiens)
NRXNs:NLGN dimer:PSD-95:GKAP1-4:SHANK1,2,3:2xHOMER1,2,3:GRM1,5 [plasma membrane] (Homo sapiens)
2xHOMER1,2,3:GRM1,GRM5 [plasma membrane] (Homo sapiens)
GRM1,GRM5 [plasma membrane] (Homo sapiens)
GRM1 [plasma membrane] (Homo sapiens)
Homer1,2,3 binds mGluR1a,5 (Homo sapiens)
GRM1,GRM5 [plasma membrane] (Homo sapiens)
GRM1 [plasma membrane] (Homo sapiens)
HOMER1,2,3:GRM1,GRM5 [plasma membrane] (Homo sapiens)
GRM1,GRM5 [plasma membrane] (Homo sapiens)
GRM1 [plasma membrane] (Homo sapiens)
Homer1,2,3 dimerizes (Homo sapiens)
2xHOMER1,2,3:GRM1,GRM5 [plasma membrane] (Homo sapiens)
GRM1,GRM5 [plasma membrane] (Homo sapiens)
GRM1 [plasma membrane] (Homo sapiens)
HOMER1,2,3:GRM1,GRM5 [plasma membrane] (Homo sapiens)
GRM1,GRM5 [plasma membrane] (Homo sapiens)
GRM1 [plasma membrane] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (q) signalling events (Homo sapiens)
Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
Group I Metabotropic glutamate receptors:Glu [plasma membrane] (Homo sapiens)
GRM1,GRM5 [plasma membrane] (Homo sapiens)
GRM1 [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
Group I Metabotropic glutamate receptors:Glu [plasma membrane] (Homo sapiens)
GRM1,GRM5 [plasma membrane] (Homo sapiens)
GRM1 [plasma membrane] (Homo sapiens)
Liganded Gq/11-activating GPCRs act as GEFs for Gq/11 (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
Group I Metabotropic glutamate receptors:Glu [plasma membrane] (Homo sapiens)
GRM1,GRM5 [plasma membrane] (Homo sapiens)
GRM1 [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
Group I Metabotropic glutamate receptors:Glu [plasma membrane] (Homo sapiens)
GRM1,GRM5 [plasma membrane] (Homo sapiens)
GRM1 [plasma membrane] (Homo sapiens)
The Ligand:GPCR:Gq complex dissociates (Homo sapiens)
GPCRs that activate Gq/11 [plasma membrane] (Homo sapiens)
GRM1,GRM5 [plasma membrane] (Homo sapiens)
GRM1 [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
Group I Metabotropic glutamate receptors:Glu [plasma membrane] (Homo sapiens)
GRM1,GRM5 [plasma membrane] (Homo sapiens)
GRM1 [plasma membrane] (Homo sapiens)
GPCR ligand binding (Homo sapiens)
Class C/3 (Metabotropic glutamate/pheromone receptors) (Homo sapiens)
Metabotropic glutamate receptors bind glutamate (Homo sapiens)
GRM1-8 [plasma membrane] (Homo sapiens)
GRM1,GRM5 [plasma membrane] (Homo sapiens)
GRM1 [plasma membrane] (Homo sapiens)
GRM1-8:L-Glu [plasma membrane] (Homo sapiens)
GRM1-8 [plasma membrane] (Homo sapiens)
GRM1,GRM5 [plasma membrane] (Homo sapiens)
GRM1 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q13255 GRM1
Gene Names
GRM1, GPRC1A, MGLUR1
Chain
signal peptide:1-18, chain:19-1194
Reference Genes
BioGPS Gene:2911 GRM1
COSMIC (genes):GRM1 GRM1
CTD Gene:2911 GRM1
dbSNP Gene:2911 GRM1
ENSEMBL:ENSG00000152822 GRM1
HGNC:4593 GRM1
KEGG:hsa:2911 GRM1
Monarch:2911 GRM1
NCBI Gene:2911 GRM1
OMIM:604473 GRM1
UCSC:Q13255 GRM1
Reference Transcript
RefSeq:XM_017010783.1 GRM1
RefSeq:XM_017010785.1 GRM1
RefSeq:XM_017010787.1 GRM1
RefSeq:XM_017010786.1 GRM1
RefSeq:NM_001278064.1 GRM1
RefSeq:NM_001278065.1 GRM1
RefSeq:XM_017010784.1 GRM1
RefSeq:NM_001278067.1 GRM1
RefSeq:XM_011535782.1 GRM1
RefSeq:NM_001278066.1 GRM1
Other Identifiers
11737999_a_at
11741117_a_at
11741118_a_at
17013385
207299_PM_s_at
207299_s_at
210939_PM_s_at
210939_s_at
210940_PM_s_at
210940_s_at
2911
2929582
2929585
2929586
2929587
2929588
2929613
2929614
2929630
2929644
2929645
2929648
2929650
2929652
2929657
2929660
2929661
2929662
2929663
2929664
2929665
2929666
2929667
2929668
2929669
2929670
2929671
2929672
2929673
31468_f_at
33509_at
33510_s_at
8122537
A_14_P101254
A_14_P113431
A_14_P113841
A_23_P30976
A_33_P3271965
GE79002
GO:0001640
GO:0004930
GO:0005515
GO:0005634
GO:0005886
GO:0007186
GO:0007196
GO:0007206
GO:0007216
GO:0007268
GO:0007626
GO:0008066
GO:0014069
GO:0016020
GO:0019233
GO:0023052
GO:0030425
GO:0038037
GO:0038038
GO:0043005
GO:0043226
GO:0043410
GO:0050877
GO:0051930
GO:0051966
GO:0055085
GO:0060078
GO:0060089
GO:0071257
GO:0098685
GO:0098712
GO:0098839
GO:0098872
GO:0098978
GO:0099530
GO:0099566
GO:0099583
HMNXSV003007309
ILMN_1670547
L76627_at
PH_hs_0002770
TC06001063.hg
U31215_s_at
U31216_s_at
g1477389_3p_a_at
g6006005_3p_a_at
g945098_3p_a_at
Participates
as a member of
GRM1,GRM5 [plasma membrane] (Homo sapiens)
Other forms of this molecule
GRM1(410-1194) [plasma membrane]
Inferred To
mgl-2 [plasma membrane]
(Caenorhabditis elegans)
GRM1 [plasma membrane]
(Bos taurus)
GRM1 [plasma membrane]
(Canis familiaris)
GRM1 [plasma membrane]
(Gallus gallus)
GRM1 [plasma membrane]
(Mus musculus)
GRM1 [plasma membrane]
(Rattus norvegicus)
GRM1 [plasma membrane]
(Sus scrofa)
grm1 [plasma membrane]
(Xenopus tropicalis)
grm1b [plasma membrane]
(Danio rerio)
Cross References
RefSeq
NP_001264995.1
,
XP_016866275.1
,
XP_016866274.1
,
NP_001264993.1
,
NP_001264996.1
,
NP_001264994.1
,
XP_016866273.1
,
XP_016866276.1
,
XP_016866272.1
,
XP_011534084.1
ZINC - World Drugs
GRM1_HUMAN
Guide to Pharmacology - Targets
289
OpenTargets
ENSG00000152822
ENSEMBL
ENSP00000516580
,
ENSP00000354896
,
ENST00000507907
,
ENST00000355289
,
ENST00000492807
,
ENST00000361719
,
ENSP00000282753
,
ENST00000282753
,
ENSP00000347437
,
ENSP00000425599
,
ENST00000706835
,
ENSP00000424095
,
ENST00000706834
,
ENST00000706833
,
ENSP00000516579
,
ENSP00000516581
,
ENST00000706836
,
ENSP00000516582
ZINC - FDA approved
GRM1_HUMAN
ZINC - Substances
GRM1_HUMAN
ZINC - Biogenic
GRM1_HUMAN
ZINC target
Q13255
PRO
Q13255
GlyGen
Q13255
PDB
7DGD
,
3KS9
,
7DGE
,
4OR2
ZINC - Investigational
GRM1_HUMAN
ZINC - Metabolites
GRM1_HUMAN
HPA
ENSG00000152822-GRM1
Pharos - Targets
Q13255
Orphanet
GRM1
ZINC - Predictions - Purchasable
GRM1_HUMAN
HMDB Protein
HMDBP02215
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P52294 KPNA1
2
KPNA1 [cytosol]
(R-HSA-180612)
KPNA1 [nucleoplasm]
(R-HSA-188865)
0.524
2
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