Reactome | GRM3 [plasma membrane]

GRM3 [plasma membrane]

Stable Identifier

R-HSA-420509

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Metabotropic glutamate receptor 3, GRM3_HUMAN

Locations in the PathwayBrowser

Expand all

Signal Transduction (Homo sapiens)

- Signaling by GPCR (Homo sapiens)
  - GPCR downstream signalling (Homo sapiens)
    - G alpha (i) signalling events (Homo sapiens)
      - Liganded Gi-activating GPCR acts as a GEF for Gi (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        Group II and III metabotropic gutamate receptors:Glu [plasma membrane] (Homo sapiens)
        
        GRM2,GRM3,GRM4,GRM6,GRM7,GRM8 [plasma membrane] (Homo sapiens)
        
        GRM3 [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        Group II and III metabotropic gutamate receptors:Glu [plasma membrane] (Homo sapiens)
        
        GRM2,GRM3,GRM4,GRM6,GRM7,GRM8 [plasma membrane] (Homo sapiens)
        
        GRM3 [plasma membrane] (Homo sapiens)
      - Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        Group II and III metabotropic gutamate receptors:Glu [plasma membrane] (Homo sapiens)
        
        GRM2,GRM3,GRM4,GRM6,GRM7,GRM8 [plasma membrane] (Homo sapiens)
        
        GRM3 [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        Group II and III metabotropic gutamate receptors:Glu [plasma membrane] (Homo sapiens)
        
        GRM2,GRM3,GRM4,GRM6,GRM7,GRM8 [plasma membrane] (Homo sapiens)
        
        GRM3 [plasma membrane] (Homo sapiens)
      - The Ligand:GPCR:Gi complex dissociates (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        Group II and III metabotropic gutamate receptors:Glu [plasma membrane] (Homo sapiens)
        
        GRM2,GRM3,GRM4,GRM6,GRM7,GRM8 [plasma membrane] (Homo sapiens)
        
        GRM3 [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        Group II and III metabotropic gutamate receptors:Glu [plasma membrane] (Homo sapiens)
        
        GRM2,GRM3,GRM4,GRM6,GRM7,GRM8 [plasma membrane] (Homo sapiens)
        
        GRM3 [plasma membrane] (Homo sapiens)
  - GPCR ligand binding (Homo sapiens)
    - Class C/3 (Metabotropic glutamate/pheromone receptors) (Homo sapiens)
      - Metabotropic glutamate receptors bind glutamate (Homo sapiens)
        
        GRM1-8 [plasma membrane] (Homo sapiens)
        
        GRM2,GRM3,GRM4,GRM6,GRM7,GRM8 [plasma membrane] (Homo sapiens)
        
        GRM3 [plasma membrane] (Homo sapiens)
        
        GRM1-8:L-Glu [plasma membrane] (Homo sapiens)
        
        GRM1-8 [plasma membrane] (Homo sapiens)
        
        GRM2,GRM3,GRM4,GRM6,GRM7,GRM8 [plasma membrane] (Homo sapiens)
        
        GRM3 [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q14832 GRM3

Gene Names

GRM3, GPRC1C, MGLUR3

Chain

signal peptide:1-22, chain:23-879

Reference Genes

BioGPS Gene:2913 GRM3

COSMIC (genes):GRM3 GRM3

CTD Gene:2913 GRM3

dbSNP Gene:2913 GRM3

ENSEMBL:ENSG00000198822 GRM3

HGNC:4595 GRM3

KEGG:hsa:2913 GRM3

Monarch:2913 GRM3

NCBI Gene:2913 GRM3

OMIM:601115 GRM3

UCSC:Q14832 GRM3

Reference Transcript

Other Identifiers

11730172_a_at

17047868

205814_PM_at

205814_at

2913

3011181

3011182

3011183

3011193

3011194

3011195

3011196

3011197

3011198

3011208

3011209

3011213

3011214

3011218

39928_at

8133904

A_14_P100991

A_14_P113254

A_23_P20068

GE60031

GO:0001641

GO:0004930

GO:0005246

GO:0005886

GO:0007165

GO:0007186

GO:0007194

GO:0007196

GO:0007216

GO:0007268

GO:0008066

GO:0010467

GO:0014069

GO:0016020

GO:0023052

GO:0030424

GO:0042734

GO:0043005

GO:0043197

GO:0043226

GO:0045211

GO:0051966

GO:0060089

GO:0097110

GO:0097449

GO:0098772

GO:0098978

GO:0099170

HMNXSV003043266

ILMN_1679532

ILMN_2078975

PH_hs_0026726

TC07000519.hg

X77748_at

g4504138_3p_at

Participates

as a member of

GRM2,GRM3,GRM4,GRM6,GRM7,GRM8 [plasma membrane] (Homo sapiens)

Inferred To

Homologues of GRM3 [plasma membrane] (Caenorhabditis elegans)

GRM3 [plasma membrane] (Bos taurus)

GRM3 [plasma membrane] (Caenorhabditis elegans)

GRM3 [plasma membrane] (Canis familiaris)

GRM3 [plasma membrane] (Drosophila melanogaster)

GRM3 [plasma membrane] (Gallus gallus)

GRM3 [plasma membrane] (Mus musculus)

GRM3 [plasma membrane] (Rattus norvegicus)

GRM3 [plasma membrane] (Sus scrofa)

grm3 [plasma membrane] (Danio rerio)

grm3 [plasma membrane] (Xenopus tropicalis)

Cross References

RefSeq

XP_011514390.1, NP_000831.2

Guide to Pharmacology - Targets

291

OpenTargets

ENSG00000198822

ENSEMBL

ENSG00000198822, ENST00000439827, ENSP00000398767, ENSP00000355316, ENST00000361669

ZINC - FDA approved

GRM3_HUMAN

ZINC - Substances

GRM3_HUMAN

ZINC - Biogenic

GRM3_HUMAN

ZINC target

Q14832

PRO

Q14832

GlyGen

Q14832

PDB

8JCX, 3SM9, 8JCV, 7WI6, 8JCW, 5CNM, 8JCU, 8JD3, 8JCY, 8JCZ, 5CNK, 8JD2, 7WIH, 8JD1, 4XAR, 8JD0, 7WI8, 6B7H

ZINC - Investigational

GRM3_HUMAN

ZINC - Metabolites

GRM3_HUMAN

HPA

ENSG00000198822-GRM3

GeneCards

GRM3

Pharos - Targets

Q14832

ZINC - Predictions - Purchasable

GRM3_HUMAN