Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
SCT [extracellular region]
Stable Identifier
R-HSA-420060
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
extracellular region
Synonyms
Secretin, SECR_HUMAN
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (s) signalling events (Homo sapiens)
Liganded Gs-activating GPCR acts as a GEF for Gs (Homo sapiens)
GPCR:ligand complexes that act on Gs:Heterotrimeric G-protein Gs (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
SCTR:SCT [plasma membrane] (Homo sapiens)
SCT [extracellular region] (Homo sapiens)
Ligand:GPCR complexes that activate Gs:Heterotrimeric G-protein Gs (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
SCTR:SCT [plasma membrane] (Homo sapiens)
SCT [extracellular region] (Homo sapiens)
Liganded Gs-activating GPCRs bind inactive heterotrimeric Gs (Homo sapiens)
Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
SCTR:SCT [plasma membrane] (Homo sapiens)
SCT [extracellular region] (Homo sapiens)
Ligand:GPCR complexes that activate Gs:Heterotrimeric G-protein Gs (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
SCTR:SCT [plasma membrane] (Homo sapiens)
SCT [extracellular region] (Homo sapiens)
The Ligand:GPCR:Gs complex dissociates (Homo sapiens)
GPCR:ligand complexes that act on Gs:Heterotrimeric G-protein Gs (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
SCTR:SCT [plasma membrane] (Homo sapiens)
SCT [extracellular region] (Homo sapiens)
Ligands of GPCRs that activate Gs [extracellular region] (Homo sapiens)
SCT [extracellular region] (Homo sapiens)
GPCR ligand binding (Homo sapiens)
Class B/2 (Secretin family receptors) (Homo sapiens)
Glucagon-type ligand receptors (Homo sapiens)
Secretin receptor binds secretin (Homo sapiens)
SCT [extracellular region] (Homo sapiens)
SCTR:SCT [plasma membrane] (Homo sapiens)
SCT [extracellular region] (Homo sapiens)
External Reference Information
External Reference
UniProt:P09683 SCT
Gene Names
SCT
Chain
signal peptide:1-18, propeptide:19-26, peptide:28-54, propeptide:58-121
Reference Genes
BioGPS Gene:6343 SCT
COSMIC (genes):SCT SCT
CTD Gene:6343 SCT
dbSNP Gene:6343 SCT
ENSEMBL:ENSG00000070031 SCT
HGNC:10607 SCT
KEGG:hsa:6343 SCT
Monarch:6343 SCT
NCBI Gene:6343 SCT
OMIM:182099 SCT
UCSC:P09683 SCT
Reference Transcript
RefSeq:NM_021920.3 SCT
Other Identifiers
11742661_at
16734040
221198_PM_at
221198_at
3358240
3358242
3358243
3358244
3358245
3358246
3358247
6343
7945498
A_23_P104594
GO:0001664
GO:0002024
GO:0005102
GO:0005179
GO:0005515
GO:0005575
GO:0005576
GO:0005615
GO:0007165
GO:0007420
GO:0009992
GO:0021766
GO:0022600
GO:0030157
GO:0031667
GO:0032098
GO:0043950
GO:0046659
GO:0048018
GO:0048167
GO:0048566
GO:0048856
GO:0050996
GO:0090187
GO:0090274
GO:0098772
GO:1903640
HMNXSV003021225
HMNXSV003049746
ILMN_1705763
PH_hs_0029684
TC11001243.hg
g12545379_3p_at
Participates
as an input of
Secretin receptor binds secretin (Homo sapiens)
as a member of
Ligands of GPCRs that activate Gs [extracellular region] (Homo sapiens)
as a component of
SCTR:SCT [plasma membrane] (Homo sapiens)
Inferred To
SCT [extracellular region]
(Bos taurus)
SCT [extracellular region]
(Canis familiaris)
SCT [extracellular region]
(Sus scrofa)
Sct [extracellular region]
(Mus musculus)
Sct [extracellular region]
(Rattus norvegicus)
Cross References
RefSeq
NP_068739.1
ENSEMBL
ENSP00000176195
,
ENST00000176195
,
ENSP00000483559
,
ENST00000622382
OpenTargets
ENSG00000070031
HPA
ENSG00000070031-SCT
PRO
P09683
Pharos - Targets
P09683
PDB
6WI9
,
7D3S
,
6WZG
Interactors (4)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q8N6Y0 USBP1
0.556
3
UniProt:O14770-4 MEIS2
0.556
3
UniProt:O14964 HGS
2
HGS [cytosol]
(R-HSA-182954)
HGS [phagocytic vesicle lumen]
(R-HSA-9635660)
0.556
3
UniProt:P49639 HOXA1
1
HOXA1 [nucleoplasm]
(R-HSA-5617464)
0.556
3
© 2025
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text