Reactome | Secretin receptor binds secretin

Secretin receptor binds secretin

Stable Identifier

R-HSA-420202

Type

Reaction [binding]

Species

Homo sapiens

Compartment

extracellular region, plasma membrane

ReviewStatus

5/5

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Secretin (SCT) (Whitmore TE et al, 2000) is a peptide hormone belonging to the glucagon peptide hormone family and is produced in the duodenum. Its primary effect is to regulate the pH of the duodenal contents via the control of gastric acid secretion and buffering with bicarbonate. These effects are mediated by the SCT receptor (Patel DR et al, 1995). The receptor activity is mediated by coupling to G protein alpha s subunits, which stimulate adenylyl cyclase which increases intracellular cAMP levels (Patel DR et al, 1995).

Literature References

PubMed ID	Title	Journal	Year
11060443	Human secretin (SCT): gene structure, chromosome location, and distribution of mRNA Whitmore, TE, Holloway, JL, Lofton-Day, CE, Maurer, MF, Chen, L, Quinton, TJ, Vincent, JB, Scherer, SW, Lok, S	Cytogenet Cell Genet	2000
7700244	Molecular cloning and expression of a human secretin receptor Patel, DR, Kong, Y, Sreedharan, SP	Mol Pharmacol	1995