Transphosphorylation of pLIMK1

Stable Identifier
R-HSA-419644
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
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Binding of Hsp90 to the LIMK proteins protects them from degradation and promotes their dimer formation and transphosphorylation. It is estimated that LIMK1 contains at least 5 phospho-amino acids primarily phospho-serines, in its kinase domain. The positions of these serine residues are not known. Transphosphorylation of these serine residues in LIMK1 increases its stability.

Literature References
PubMed ID Title Journal Year
7848918 Kiz-1, a protein with LIM zinc finger and kinase domains, is expressed mainly in neurons

Bernard, O, Ganiatsas, S, Kannourakis, G, Dringen, R

Cell Growth Differ 1994
16641196 Hsp90 increases LIM kinase activity by promoting its homo-dimerization

Li, R, Soosairajah, J, Harari, D, Citri, A, Price, J, Ng, HL, Morton, CJ, Parker, MW, Yarden, Y, Bernard, O

FASEB J 2006
17188549 Lim kinases, regulators of actin dynamics

Bernard, O

Int J Biochem Cell Biol 2007
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein serine/threonine kinase activity of pLIMK dimer:HSP-90 [cytosol]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created