Reactome | Transphosphorylation of pLIMK1

Transphosphorylation of pLIMK1

Stable Identifier

R-HSA-419644

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Binding of Hsp90 to the LIMK proteins protects them from degradation and promotes their dimer formation and transphosphorylation. It is estimated that LIMK1 contains at least 5 phospho-amino acids primarily phospho-serines, in its kinase domain. The positions of these serine residues are not known. Transphosphorylation of these serine residues in LIMK1 increases its stability.

Literature References

PubMed ID	Title	Journal	Year
16641196	Hsp90 increases LIM kinase activity by promoting its homo-dimerization Yarden, Y, Soosairajah, J, Morton, CJ, Harari, D, Li, R, Bernard, O, Parker, MW, Ng, HL, Price, J, Citri, A	FASEB J	2006
7848918	Kiz-1, a protein with LIM zinc finger and kinase domains, is expressed mainly in neurons Kannourakis, G, Ganiatsas, S, Dringen, R, Bernard, O	Cell Growth Differ	1994
17188549	Lim kinases, regulators of actin dynamics Bernard, O	Int J Biochem Cell Biol	2007