Sema3A PAK dependent Axon repulsion

Stable Identifier
R-HSA-399954
Type
Pathway
Species
Homo sapiens
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Sema3A PAK dependent Axon repulsion
Click the image above or here to open this pathway in the Pathway Browser
Activated Rac1 bound to plexin-A might modulate actin dynamics through the sequential phosphorylation and activation of PAK, LIMK1 and cofilin.
Literature References
PubMed ID Title Journal Year
11276226 Phosphorylation of cofilin by LIM-kinase is necessary for semaphorin 3A-induced growth cone collapse

Aizawa, H, Wakatsuki, S, Ishii, A, Moriyama, K, Sasaki, Y, Ohashi, K, Sekine-Aizawa, Y, Sehara-Fujisawa, A, Mizuno, K, Goshima, Y, Yahara, I

Nat Neurosci 2001
11604131 Plexin signaling via off-track and rho family GTPases

Whitford, KL, Ghosh, A

Neuron 2001
18374575 Semaphorin signaling: progress made and promises ahead

Zhou, Y, Gunput, RA, Pasterkamp, RJ

Trends Biochem Sci 2008
12593985 Semaphorin junction: making tracks toward neural connectivity

Pasterkamp, RJ, Kolodkin, AL

Curr Opin Neurobiol 2003
Participants
Events
Participates
as an event of
Orthologous Events
Sema3A PAK dependent Axon repulsion (Bos taurus)
Sema3A PAK dependent Axon repulsion (Canis familiaris)
Sema3A PAK dependent Axon repulsion (Danio rerio)
Sema3A PAK dependent Axon repulsion (Dictyostelium discoideum)
Sema3A PAK dependent Axon repulsion (Drosophila melanogaster)
Sema3A PAK dependent Axon repulsion (Gallus gallus)
Sema3A PAK dependent Axon repulsion (Mus musculus)
Sema3A PAK dependent Axon repulsion (Rattus norvegicus)
Sema3A PAK dependent Axon repulsion (Sus scrofa)
Sema3A PAK dependent Axon repulsion (Xenopus tropicalis)
Authored
Garapati, P V  (2009-03-23)
Reviewed
Kumanogoh, A  (2009-09-02)
Kikutani, H  (2009-09-02)
Created
Garapati, P V  (2009-03-23)
Cite Us!