Reactome | p-Y-PLXNA1 [plasma membrane]

p-Y-PLXNA1 [plasma membrane]

Stable Identifier

R-HSA-419614

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

phosphorylated Plexin-A1

Locations in the PathwayBrowser

Expand all

Developmental Biology (Homo sapiens)

- Nervous system development (Homo sapiens)
  - Axon guidance (Homo sapiens)
    - Semaphorin interactions (Homo sapiens)
      - CRMPs in Sema3A signaling (Homo sapiens)
        
        Tyrosine phosphorylation of CRMPs by Fes (Homo sapiens)
        
        Sema3A:NP-1:Plexin-A:Fes:CRMP [plasma membrane] (Homo sapiens)
        
        Sema3A:NRP-1:pPlexin-A:Fyn:Fes [plasma membrane] (Homo sapiens)
        
        Sema3A:NRP-1:pPlexin-A:fyn [plasma membrane] (Homo sapiens)
        
        NRP1:p-Plexin-A1-4:FYN [plasma membrane] (Homo sapiens)
        
        p-Plexin-A1-4 [plasma membrane] (Homo sapiens)
        
        p-Y-PLXNA1 [plasma membrane] (Homo sapiens)
        
        Sema3A:NRP-1:pPlexin-A:Fyn:Fes [plasma membrane] (Homo sapiens)
        
        Sema3A:NRP-1:pPlexin-A:fyn [plasma membrane] (Homo sapiens)
        
        NRP1:p-Plexin-A1-4:FYN [plasma membrane] (Homo sapiens)
        
        p-Plexin-A1-4 [plasma membrane] (Homo sapiens)
        
        p-Y-PLXNA1 [plasma membrane] (Homo sapiens)
      - SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion (Homo sapiens)
        
        Inactivation of R-Ras by Sema3A-Plexin-A GAP activity (Homo sapiens)
        
        Sema3A:Nrp-1:pPlexinA:Fyn:Fes:Rac-1-GTP:Rnd1 [plasma membrane] (Homo sapiens)
        
        Sema3A:Nrp-1:pPlexinA:Fyn:Fes:Rac-1-GTP [plasma membrane] (Homo sapiens)
        
        Sema3A:NRP-1:pPlexin-A:Fyn:Fes [plasma membrane] (Homo sapiens)
        
        Sema3A:NRP-1:pPlexin-A:fyn [plasma membrane] (Homo sapiens)
        
        NRP1:p-Plexin-A1-4:FYN [plasma membrane] (Homo sapiens)
        
        p-Plexin-A1-4 [plasma membrane] (Homo sapiens)
        
        p-Y-PLXNA1 [plasma membrane] (Homo sapiens)
        
        Phosphorylation of Plexin-A (Homo sapiens)
        
        Sema3A:NRP-1:pPlexin-A:Fyn:Fes [plasma membrane] (Homo sapiens)
        
        Sema3A:NRP-1:pPlexin-A:fyn [plasma membrane] (Homo sapiens)
        
        NRP1:p-Plexin-A1-4:FYN [plasma membrane] (Homo sapiens)
        
        p-Plexin-A1-4 [plasma membrane] (Homo sapiens)
        
        p-Y-PLXNA1 [plasma membrane] (Homo sapiens)
        
        Rac1 binds PlexinA (Homo sapiens)
        
        Sema3A:NRP-1:pPlexin-A:Fyn:Fes [plasma membrane] (Homo sapiens)
        
        Sema3A:NRP-1:pPlexin-A:fyn [plasma membrane] (Homo sapiens)
        
        NRP1:p-Plexin-A1-4:FYN [plasma membrane] (Homo sapiens)
        
        p-Plexin-A1-4 [plasma membrane] (Homo sapiens)
        
        p-Y-PLXNA1 [plasma membrane] (Homo sapiens)
        
        Sema3A:Nrp-1:pPlexinA:Fyn:Fes:Rac-1-GTP [plasma membrane] (Homo sapiens)
        
        Sema3A:NRP-1:pPlexin-A:Fyn:Fes [plasma membrane] (Homo sapiens)
        
        Sema3A:NRP-1:pPlexin-A:fyn [plasma membrane] (Homo sapiens)
        
        NRP1:p-Plexin-A1-4:FYN [plasma membrane] (Homo sapiens)
        
        p-Plexin-A1-4 [plasma membrane] (Homo sapiens)
        
        p-Y-PLXNA1 [plasma membrane] (Homo sapiens)
        
        Recruitment of Rnd1 to Plexin A (Homo sapiens)
        
        Sema3A:Nrp-1:pPlexinA:Fyn:Fes:Rac-1-GTP [plasma membrane] (Homo sapiens)
        
        Sema3A:NRP-1:pPlexin-A:Fyn:Fes [plasma membrane] (Homo sapiens)
        
        Sema3A:NRP-1:pPlexin-A:fyn [plasma membrane] (Homo sapiens)
        
        NRP1:p-Plexin-A1-4:FYN [plasma membrane] (Homo sapiens)
        
        p-Plexin-A1-4 [plasma membrane] (Homo sapiens)
        
        p-Y-PLXNA1 [plasma membrane] (Homo sapiens)
        
        Sema3A:Nrp-1:pPlexinA:Fyn:Fes:Rac-1-GTP:Rnd1 [plasma membrane] (Homo sapiens)
        
        Sema3A:Nrp-1:pPlexinA:Fyn:Fes:Rac-1-GTP [plasma membrane] (Homo sapiens)
        
        Sema3A:NRP-1:pPlexin-A:Fyn:Fes [plasma membrane] (Homo sapiens)
        
        Sema3A:NRP-1:pPlexin-A:fyn [plasma membrane] (Homo sapiens)
        
        NRP1:p-Plexin-A1-4:FYN [plasma membrane] (Homo sapiens)
        
        p-Plexin-A1-4 [plasma membrane] (Homo sapiens)
        
        p-Y-PLXNA1 [plasma membrane] (Homo sapiens)
      - Sema3A PAK dependent Axon repulsion (Homo sapiens)
        
        Activation of PAK by Rac1 (Homo sapiens)
        
        Sema3A:Nrp-1:PlexinA:Rac1-GTP:PAK [plasma membrane] (Homo sapiens)
        
        Sema3A:Nrp-1:pPlexinA:Fyn:Fes:Rac-1-GTP [plasma membrane] (Homo sapiens)
        
        Sema3A:NRP-1:pPlexin-A:Fyn:Fes [plasma membrane] (Homo sapiens)
        
        Sema3A:NRP-1:pPlexin-A:fyn [plasma membrane] (Homo sapiens)
        
        NRP1:p-Plexin-A1-4:FYN [plasma membrane] (Homo sapiens)
        
        p-Plexin-A1-4 [plasma membrane] (Homo sapiens)
        
        p-Y-PLXNA1 [plasma membrane] (Homo sapiens)
        
        Sema3A:Nrp-1:pPlexinA:Fyn:Fes:Rac-1-GTP [plasma membrane] (Homo sapiens)
        
        Sema3A:NRP-1:pPlexin-A:Fyn:Fes [plasma membrane] (Homo sapiens)
        
        Sema3A:NRP-1:pPlexin-A:fyn [plasma membrane] (Homo sapiens)
        
        NRP1:p-Plexin-A1-4:FYN [plasma membrane] (Homo sapiens)
        
        p-Plexin-A1-4 [plasma membrane] (Homo sapiens)
        
        p-Y-PLXNA1 [plasma membrane] (Homo sapiens)
        
        Autophosphorylation of PAK (Homo sapiens)
        
        Sema3A:Nrp-1:PlexinA:Rac1-GTP:PAK [plasma membrane] (Homo sapiens)
        
        Sema3A:Nrp-1:pPlexinA:Fyn:Fes:Rac-1-GTP [plasma membrane] (Homo sapiens)
        
        Sema3A:NRP-1:pPlexin-A:Fyn:Fes [plasma membrane] (Homo sapiens)
        
        Sema3A:NRP-1:pPlexin-A:fyn [plasma membrane] (Homo sapiens)
        
        NRP1:p-Plexin-A1-4:FYN [plasma membrane] (Homo sapiens)
        
        p-Plexin-A1-4 [plasma membrane] (Homo sapiens)
        
        p-Y-PLXNA1 [plasma membrane] (Homo sapiens)
        
        Sema3A:Nrp-1:PlexinA:Rac1-GTP:pPAK [plasma membrane] (Homo sapiens)
        
        Sema3A:Nrp-1:pPlexinA:Fyn:Fes:Rac-1-GTP [plasma membrane] (Homo sapiens)
        
        Sema3A:NRP-1:pPlexin-A:Fyn:Fes [plasma membrane] (Homo sapiens)
        
        Sema3A:NRP-1:pPlexin-A:fyn [plasma membrane] (Homo sapiens)
        
        NRP1:p-Plexin-A1-4:FYN [plasma membrane] (Homo sapiens)
        
        p-Plexin-A1-4 [plasma membrane] (Homo sapiens)
        
        p-Y-PLXNA1 [plasma membrane] (Homo sapiens)
        
        Phosphorylation of LIMK-1 by PAK (Homo sapiens)
        
        Sema3A:Nrp-1:PlexinA:Rac1-GTP:pPAK [plasma membrane] (Homo sapiens)
        
        Sema3A:Nrp-1:pPlexinA:Fyn:Fes:Rac-1-GTP [plasma membrane] (Homo sapiens)
        
        Sema3A:NRP-1:pPlexin-A:Fyn:Fes [plasma membrane] (Homo sapiens)
        
        Sema3A:NRP-1:pPlexin-A:fyn [plasma membrane] (Homo sapiens)
        
        NRP1:p-Plexin-A1-4:FYN [plasma membrane] (Homo sapiens)
        
        p-Plexin-A1-4 [plasma membrane] (Homo sapiens)
        
        p-Y-PLXNA1 [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9UIW2 PLXNA1

Gene Names

PLXNA1, NOV, PLXN1

Chain

signal peptide:1-26, chain:27-1896

Reference Genes

BioGPS Gene:5361 PLXNA1

COSMIC (genes):PLXNA1 PLXNA1

CTD Gene:5361 PLXNA1

dbSNP Gene:5361 PLXNA1

ENSEMBL:ENSG00000114554 PLXNA1

HGNC:9099 PLXNA1

KEGG:hsa:5361 PLXNA1

Monarch:5361 PLXNA1

NCBI Gene:5361 PLXNA1

OMIM:601055 PLXNA1

UCSC:Q9UIW2 PLXNA1

Reference Transcript

RefSeq:NM_032242.3 PLXNA1

Other Identifiers

11719639_a_at

11719640_a_at

1558140_PM_at

1558140_at

16945051

221537_PM_at

221537_at

221538_PM_s_at

221538_s_at

2640580

2640581

2640582

2640583

2640584

2640585

2640587

2640600

2640601

2640602

2640603

2640604

2640606

2640607

2640608

2640609

2640610

2640611

2640612

2640613

2640614

2640615

2640616

2640617

2640619

2640621

2640623

2640624

2640625

2640627

2640628

2640630

2640632

2640633

2640635

2640636

2640637

2640638

2640639

2640642

2640643

2640646

2640647

2640648

2640649

2640651

2640652

46601_at

5361

8082314

A_14_P138535

A_23_P57667

A_23_P69068

GE87012

GO:0002116

GO:0002291

GO:0002376

GO:0005515

GO:0005654

GO:0005829

GO:0005886

GO:0007162

GO:0008360

GO:0014910

GO:0016020

GO:0017154

GO:0021628

GO:0021828

GO:0030334

GO:0043226

GO:0045202

GO:0048870

GO:0050772

GO:0060089

GO:0060666

GO:0070062

GO:0071526

GO:0097485

GO:0098978

GO:1990138

HMNXSV003001330

Hs.322844.0.S1_3p_at

Hs.322844.0.S1_3p_x_at

Hs2.398130.1.S1_3p_s_at

ILMN_1791569

PH_hs_0026963

PH_hs_0033303

PH_hs_0041172

TC03000661.hg

TC03002520.hg

g12052849_3p_a_at

Participates

as a member of

p-Plexin-A1-4 [plasma membrane] (Homo sapiens)

Other forms of this molecule

PLXNA1 [plasma membrane]

Inferred To

phospho-Plxna1 [plasma membrane] (Mus musculus)

phospho-Plxna1 [plasma membrane] (Rattus norvegicus)

phospho-PlexA [plasma membrane] (Drosophila melanogaster)

phospho-plxna1 [plasma membrane] (Xenopus tropicalis)

phospho-plxna1b [plasma membrane] (Danio rerio)

phospho-plx-1 [plasma membrane] (Caenorhabditis elegans)

phospho-p-Y-PLXNA1 [plasma membrane] (Gallus gallus)

phospho-PLXNA1 [plasma membrane] (Bos taurus)

phospho-PLXNA1 [plasma membrane] (Canis familiaris)

phospho-PLXNA1 [plasma membrane] (Sus scrofa)

Modified Residues

Name

O4'-phospho-L-tyrosine at unknown position

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Cross References

RefSeq

NP_115618.3

ENSEMBL

ENSP00000377061, ENST00000393409

OpenTargets

ENSG00000114554

HPA

ENSG00000114554-PLXNA1

PRO

Q9UIW2

Pharos - Targets

Q9UIW2

GlyGen

Q9UIW2

Orphanet

PLXNA1

PDB

7Y4P, 7Y4Q

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P59665 DEFA1	9	DEFA1(20-94) [Golgi lumen] (R-HSA-1467282) DEFA1(66-94) [Golgi lumen] (R-HSA-975663) DEFA1(20-65) [Golgi lumen] (R-HSA-8864970) DEFA1(1-94) [Golgi lumen] (R-HSA-1467215) DEFA1(66-94) [extracellular region] (R-HSA-1461998) DEFA1(66-94) [azurophil granule lumen] (R-HSA-1470038) DEFA1(65-94) [extracellular region] (R-HSA-1462022) omega-N-(ADP-ribosyl)-L-arginine-DEFA1(65-94) [extracellular region] (R-HSA-1972397) DEFA1(65-94) [azurophil granule lumen] (R-HSA-1470053)	0.527	2
UniProt:Q01523 DEFA5	5	DEFA5(1-94) [Golgi lumen] (R-HSA-1467267) DEFA5(20-94) [Golgi lumen] (R-HSA-1467208) DEFA5(20-94) [secretory granule lumen] (R-HSA-1471358) DEFA5(20-94) [extracellular region] (R-HSA-1471344) DEFA5(?-94) [extracellular region] (R-HSA-1462017)	0.527	2

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