FADK1 interacts with the C-terminal P3 domain of DCC complexed with Netrin-1, and undergoes tyrosine phosphorylation and activation. Netrin-1-DCC binding thus leads to the autophosphorylation of tyrosine 393 in FADK1.
Chen, ZF, Wang, Q, Xie, Y, Ming, GL, Feng, Z, Sun, DM, Mei, L, Zhao, ZQ, Hong, Y, Song, HJ, Ren, XR, Xiong, WC, Shim, S
protein tyrosine kinase activity of Focal adhesion kinase 1 [cytosol]
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