Phosphorylation of FADK1

Stable Identifier
R-MMU-421694
Type
Reaction [transition]
Species
Mus musculus
Compartment
cytosol, plasma membrane
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Phosphorylation of FADK1
FADK1 interacts with the C-terminal P3 domain of DCC complexed with Netrin-1, and undergoes tyrosine phosphorylation and activation. Netrin-1-DCC binding thus leads to the autophosphorylation of tyrosine 393 in FADK1.
Literature References
PubMed ID Title Journal Year
15494733 Focal adhesion kinase in netrin-1 signaling

Chen, ZF, Wang, Q, Xie, Y, Ming, GL, Feng, Z, Sun, DM, Mei, L, Zhao, ZQ, Hong, Y, Song, HJ, Ren, XR, Xiong, WC, Shim, S

Nat Neurosci 2004
Participants
Input
Output
Catalyst Activity

protein tyrosine kinase activity of Focal adhesion kinase 1 [cytosol]

Physical Entity
Focal adhesion kinase 1 [cytosol] (Mus musculus)
Activity
protein tyrosine kinase activity (GO:0004713)
Orthologous Events
Phosphorylation of FADK1 (Homo sapiens)
Authored
Garapati, P V  (2008-07-30)
Reviewed
Cooper, HM  (2010-02-16)
Created
Garapati, P V  (2009-05-19)
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