Phosphorylation of FADK1

Stable Identifier
R-MMU-421694
Type
Reaction [transition]
Species
Mus musculus
Compartment
cytosol, plasma membrane
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Phosphorylation of FADK1
FADK1 interacts with the C-terminal P3 domain of DCC complexed with Netrin-1, and undergoes tyrosine phosphorylation and activation. Netrin-1-DCC binding thus leads to the autophosphorylation of tyrosine 393 in FADK1.
Literature References
PubMed ID Title Journal Year
15494733 Focal adhesion kinase in netrin-1 signaling

Ren, XR, Ming, GL, Xie, Y, Hong, Y, Sun, DM, Zhao, ZQ, Feng, Z, Wang, Q, Shim, S, Chen, ZF, Song, HJ, Mei, L, Xiong, WC

Nat Neurosci 2004
Participants
Input
Output
Catalyst Activity

protein tyrosine kinase activity of Focal adhesion kinase 1 [cytosol]

Physical Entity
Focal adhesion kinase 1 [cytosol] (Mus musculus)
Activity
protein tyrosine kinase activity (GO:0004713)
Orthologous Events
Phosphorylation of FADK1 (Homo sapiens)
Authored
Garapati, P V  (2008-07-30)
Reviewed
Cooper, HM  (2010-02-16)
Created
Garapati, P V  (2009-05-19)
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