Phosphorylation of Unc5C

Stable Identifier
R-HSA-418859
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Multiple sites on UNC5C are phosphorylated after NTN1 (netrin-1) stimulation. An activated SRC tyrosine kinase induces phosphorylation of UNC5C at multiple cytoplasmic tyrosine residues including highly-conserved residues 449, 454, 568, 649 and 667. Phosphorylation of these residues creates potential binding sites for cytoplasmic signaling proteins.

Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein tyrosine kinase activity of MyrG-p-Y419-SRC [plasma membrane]
Physical Entity
Activity
Inferred From
Authored
Reviewed
Created
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