Phosphorylation of Unc5C

Stable Identifier
R-HSA-418859
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
ReviewStatus
5/5
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Phosphorylation of Unc5C
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Multiple sites on UNC5C are phosphorylated after NTN1 (netrin-1) stimulation. An activated SRC tyrosine kinase induces phosphorylation of UNC5C at multiple cytoplasmic tyrosine residues including highly-conserved residues 449, 454, 568, 649 and 667. Phosphorylation of these residues creates potential binding sites for cytoplasmic signaling proteins.
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Catalyst Activity

protein tyrosine kinase activity of MyrG-p-Y419-SRC [plasma membrane]

Physical Entity
MyrG-p-Y419-SRC [plasma membrane] (Homo sapiens)
Activity
protein tyrosine kinase activity (GO:0004713)
Inferred From
Phosphorylation of Unc5C (Mus musculus)
Authored
Garapati, P V  (2008-07-16)
Reviewed
Cooper, HM  (2010-02-16)
Created
Garapati, P V  (2009-04-27)
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