Phosphorylation of Unc5C

Stable Identifier
R-MMU-418870
Type
Reaction [transition]
Species
Mus musculus
Compartment
General
SVG |   | PPTX  | SBGN
Phosphorylation of Unc5C

Multiple sites on UNC5C are phosphorylated after NTN1 (netrin-1) stimulation. An activated SRC tyrosine kinase induces phosphorylation of UNC5C at multiple cytoplasmic tyrosine residues including highly-conserved residues 449, 454, 568, 649 and 667. Phosphorylation of these residues creates potential binding sites for cytoplasmic signaling proteins.

Literature References
PubMed ID Title Journal Year
11533026 Netrin stimulates tyrosine phosphorylation of the UNC-5 family of netrin receptors and induces Shp2 binding to the RCM cytodomain

Tong, J, Killeen, M, Steven, R, Binns, KL, Culotti, J, Pawson, T

J Biol Chem 2001
17254765 Netrin signaling leading to directed growth cone steering

Round, J, Stein, E

Curr Opin Neurobiol 2007
Participants
Catalyst Activity
Catalyst Activity
Title
protein tyrosine kinase activity of Src [cytosol]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created