Reactome | PDE5A [cytosol]

PDE5A [cytosol]

Stable Identifier

R-HSA-418508

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Phosphodiesterase 5A, cGMP-specific 3',5'-cyclic phosphodiesterase 5A, PDE5A_HUMAN

Locations in the PathwayBrowser

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Hemostasis (Homo sapiens)

- Platelet homeostasis (Homo sapiens)
  - Nitric oxide stimulates guanylate cyclase (Homo sapiens)
    - cGMP effects (Homo sapiens)
      - cGMP is degraded by PDEs (Homo sapiens)
        
        cGMP phosphodiesterases [cytosol] (Homo sapiens)
        
        Phosphodiesterases, cyclic GMP-selective [cytosol] (Homo sapiens)
        
        PDE5A [cytosol] (Homo sapiens)

Signal Transduction (Homo sapiens)

- Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Homo sapiens)
  - Signaling by Rho GTPases (Homo sapiens)
    - RHO GTPase cycle (Homo sapiens)
      - RHOBTB GTPase Cycle (Homo sapiens)
        
        RHOBTB1 GTPase cycle (Homo sapiens)
        
        RHOBTB1 binds interacting proteins at the endosome membrane (Homo sapiens)
        
        RHOBTB1 interacting proteins [cytosol] (Homo sapiens)
        
        PDE5A [cytosol] (Homo sapiens)
        
        RHOBTB1:GTP:RHOBTB1 interacting proteins [endosome membrane] (Homo sapiens)
        
        RHOBTB1 interacting proteins [cytosol] (Homo sapiens)
        
        PDE5A [cytosol] (Homo sapiens)

General

cGMP selective hydrolase

External Reference Information

External Reference

UniProt:O76074 PDE5A

Gene Names

PDE5A, PDE5

Chain

chain:1-875

Reference Genes

BioGPS Gene:8654 PDE5A

COSMIC (genes):PDE5A PDE5A

CTD Gene:8654 PDE5A

dbSNP Gene:8654 PDE5A

ENSEMBL:ENSG00000138735 PDE5A

ENSEMBL_homo_sapiens_GENE:ENSG00000138735.16 PDE5A

HGNC:8784 PDE5A

KEGG Gene (Homo sapiens):8654 PDE5A

Monarch:8654 PDE5A

NCBI Gene:8654 PDE5A

OMIM:603310 PDE5A

UCSC:O76074 PDE5A

Reference Transcript

Other Identifiers

11720578_a_at

11720579_a_at

1553175_PM_s_at

1553175_s_at

1562227_PM_at

1562227_at

1562228_PM_s_at

1562228_s_at

16979339

206757_PM_at

206757_at

227088_PM_at

227088_at

2783597

2783598

2783599

2783600

2783601

2783605

2783608

2783610

2783612

2783614

2783615

2783616

2783623

2783626

2783629

2783633

2783637

2783638

2783644

2783646

2783650

2783651

2783652

2783653

2783654

2783659

2783662

2783663

2783665

2783666

2783667

2783668

2783669

2783670

2783671

34953_i_at

34954_r_at

54668_at

70665_at

8102532

84162_at

8654

A_24_P911678

A_33_P3378514

GE79789

GE88689

GE88690

GO:0000166

GO:0002376

GO:0003012

GO:0003013

GO:0003824

GO:0004112

GO:0004114

GO:0005515

GO:0005575

GO:0005829

GO:0007155

GO:0007165

GO:0008081

GO:0008152

GO:0010613

GO:0010749

GO:0016787

GO:0022414

GO:0023052

GO:0030154

GO:0030553

GO:0042098

GO:0042130

GO:0046068

GO:0046069

GO:0046872

GO:0047555

GO:0048599

GO:0048856

GO:0055086

GO:0055118

GO:0055119

GO:0060282

GO:1901135

HMNXSV003046265

Hs.16578.0.A1_3p_at

Hs2.121852.1.S1_3p_s_at

Hs2.121852.4.S1_3p_s_at

ILMN_1695288

ILMN_1723230

ILMN_1810836

ILMN_2282729

ILMN_2294653

ILMN_2408024

PH_hs_0024726

TC04001504.hg

TC04002693.hg

g4505666_3p_at

Participates

as a member of

as a component of

PDE5A dimer [cytosol] (Homo sapiens)

Inferred To

PDE5A [cytosol] (Bos taurus)

PDE5A [cytosol] (Canis familiaris)

PDE5A [cytosol] (Drosophila melanogaster)

PDE5A [cytosol] (Gallus gallus)

PDE5A [cytosol] (Mus musculus)

PDE5A [cytosol] (Rattus norvegicus)

PDE5A [cytosol] (Sus scrofa)

PDE5A [cytosol] (Xenopus tropicalis)

Homologues of PDE5A [cytosol] (Canis familiaris)

Cross References

RefSeq

NP_001074.2, NP_246273.2, NP_236914.2

ZINC - World Drugs

PDE5A_HUMAN

Guide to Pharmacology - Targets

1304

OpenTargets

ENSG00000138735

ZINC - FDA approved

PDE5A_HUMAN

ZINC - Substances

PDE5A_HUMAN

ZINC - Biogenic

PDE5A_HUMAN

ZINC target

O76074

PRO

O76074

PDB

4G2Y, 3SIE, 3HC8, 7FAR, 4IA0, 3SHZ, 6VBI, 3B2R, 3MF0, 1T9S, 1T9R, 5ZZ2, 3TGE, 1TBF, 3HDZ, 6ACB, 1XOZ, 5JO3, 3LFV, 4I9Z, 4MD6, 3TGG, 3JWQ, 1RKP, 3BJC, 2CHM, 1XP0, 3JWR, 2H40, 7FAQ, 4G2W, 2H44, 1UHO, 3SHY, 4OEX, 6L6E, 4OEW, 2XSS, 2H42, 1UDU, 6IWI, 1UDT

ZINC - Investigational

PDE5A_HUMAN

HPA

ENSG00000138735-PDE5A

GeneCards

O76074

Ensembl

ENSG00000138735, ENST00000354960, ENSP00000264805, ENST00000264805, ENSP00000347046

Pharos - Targets

O76074

ZINC - Predictions - Purchasable

PDE5A_HUMAN

HMDB Protein

HMDBP00655