Reactome | PDE5A [cytosol]

PDE5A [cytosol]

Stable Identifier

R-HSA-418508

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Phosphodiesterase 5A, cGMP-specific 3',5'-cyclic phosphodiesterase 5A, PDE5A_HUMAN

Locations in the PathwayBrowser

Expand all

Hemostasis (Homo sapiens)

- Platelet homeostasis (Homo sapiens)
  - Nitric oxide stimulates guanylate cyclase (Homo sapiens)
    - cGMP effects (Homo sapiens)
      - cGMP is degraded by PDEs (Homo sapiens)
        
        cGMP phosphodiesterases [cytosol] (Homo sapiens)
        
        Phosphodiesterases, cyclic GMP-selective [cytosol] (Homo sapiens)
        
        PDE5A [cytosol] (Homo sapiens)

Signal Transduction (Homo sapiens)

- Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Homo sapiens)
  - Signaling by Rho GTPases (Homo sapiens)
    - RHO GTPase cycle (Homo sapiens)
      - RHOBTB GTPase Cycle (Homo sapiens)
        
        RHOBTB1 GTPase cycle (Homo sapiens)
        
        RHOBTB1 binds interacting proteins at the endosome membrane (Homo sapiens)
        
        RHOBTB1 interacting proteins [cytosol] (Homo sapiens)
        
        PDE5A [cytosol] (Homo sapiens)
        
        RHOBTB1:GTP:RHOBTB1 interacting proteins [endosome membrane] (Homo sapiens)
        
        RHOBTB1 interacting proteins [cytosol] (Homo sapiens)
        
        PDE5A [cytosol] (Homo sapiens)

General

cGMP selective hydrolase

External Reference Information

External Reference

UniProt:O76074 PDE5A

Gene Names

PDE5A, PDE5

Chain

chain:1-875

Reference Genes

BioGPS Gene:8654 PDE5A

COSMIC (genes):PDE5A PDE5A

CTD Gene:8654 PDE5A

dbSNP Gene:8654 PDE5A

ENSEMBL:ENSG00000138735 PDE5A

HGNC:8784 PDE5A

KEGG Gene (Homo sapiens):8654 PDE5A

Monarch:8654 PDE5A

NCBI Gene:8654 PDE5A

OMIM:603310 PDE5A

UCSC:O76074 PDE5A

Reference Transcript

Other Identifiers

0002810093

11720578_a_at

11720579_a_at

1553175_s_at

1562227_at

1562228_s_at

16979339

206757_at

227088_at

2783597

2783598

2783599

2783600

2783601

2783605

2783608

2783610

2783612

2783614

2783615

2783616

2783623

2783626

2783629

2783633

2783637

2783638

2783644

2783646

2783650

2783651

2783652

2783653

2783654

2783659

2783662

2783663

2783665

2783666

2783667

2783668

2783669

2783670

2783671

34953_i_at

34954_r_at

54668_at

70665_at

8102532

84162_at

8654

A_23_P500844

A_24_P911678

A_33_P3378514

GE79789

GE88689

GE88690

GO:0000166

GO:0003674

GO:0003824

GO:0004114

GO:0005515

GO:0005575

GO:0005622

GO:0005737

GO:0005829

GO:0007165

GO:0008081

GO:0008150

GO:0008152

GO:0009056

GO:0009058

GO:0016787

GO:0030553

GO:0034641

GO:0034655

GO:0043167

GO:0044281

GO:0046069

GO:0046872

GO:0047555

HMNXSV003046265

Hs.16578.0.A1_3p_at

Hs2.121852.1.S1_3p_s_at

Hs2.121852.4.S1_3p_s_at

ILMN_1695288

ILMN_1723230

ILMN_1730241

ILMN_1810836

ILMN_2282729

ILMN_2294653

ILMN_2408024

PH_hs_0024726

TC04001504.hg

TC04002693.hg

g4505666_3p_at

Participates

as a member of

Inferred To

pde5ab [cytosol] (Danio rerio)

Pde6 [cytosol] (Drosophila melanogaster)

pde3 [cytosol] (Dictyostelium discoideum)

PDE5A [cytosol] (Canis familiaris)

PDE5A [cytosol] (Gallus gallus)

PDE5A [cytosol] (Sus scrofa)

Pde5a [cytosol] (Mus musculus)

Pde5a [cytosol] (Rattus norvegicus)

pde5a [cytosol] (Xenopus tropicalis)

PDE2 [cytosol] (Saccharomyces cerevisiae)

Cross References

RefSeq

NP_236914.2, NP_001074.2, NP_246273.2

ZINC - World Drugs

PDE5A_HUMAN

Guide to Pharmacology - Targets

1304

OpenTargets

ENSG00000138735

ZINC - FDA approved

PDE5A_HUMAN

ZINC - Substances

PDE5A_HUMAN

ZINC target

O76074

ZINC - Biogenic

PDE5A_HUMAN

PRO

O76074

PDB

2H42, 1RKP, 1XOZ, 2XSS, 6ACB, 6IWI, 2H44, 5JO3, 4MD6, 1TBF, 4I9Z, 1XP0, 3LFV, 3BJC, 2CHM, 2H40, 3JWR, 3TGG, 3TGE, 3JWQ, 5ZZ2, 3HDZ, 1T9R, 3SIE, 1T9S, 1UDU, 4G2Y, 3SHZ, 4G2W, 1UHO, 3MF0, 4IA0, 3HC8, 6VBI, 4OEX, 3SHY, 1UDT, 4OEW, 3B2R, 6L6E

ZINC - Investigational

PDE5A_HUMAN

GeneCards

O76074

HPA

ENSG00000138735-PDE5A

Ensembl

ENST00000354960, ENSP00000264805, ENSP00000347046, ENST00000264805, ENSG00000138735

Pharos - Targets

O76074

ZINC - Predictions - Purchasable

PDE5A_HUMAN

HMDB Protein

HMDBP00655