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P2RY11 [plasma membrane]
Stable Identifier
R-HSA-417837
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
P2Y purinoceptor 11, P2Y11_HUMAN
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Infectious disease (Homo sapiens)
Leishmania infection (Homo sapiens)
Leishmania parasite growth and survival (Homo sapiens)
Anti-inflammatory response favouring Leishmania parasite infection (Homo sapiens)
ADORA2B mediated anti-inflammatory cytokines production (Homo sapiens)
ADORA2B (in Ade-Rib:ADORA2B:Heterotrimeric G-protein Gs) exchanges GDP for GTP on Gs (Homo sapiens)
Ligand:GPCR complexes that activate Gs:Heterotrimeric G-protein Gs (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
P2RY11 :ATP [plasma membrane] (Homo sapiens)
P2RY11 [plasma membrane] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (q) signalling events (Homo sapiens)
Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
P2RY11 :ATP [plasma membrane] (Homo sapiens)
P2RY11 [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
P2RY11 :ATP [plasma membrane] (Homo sapiens)
P2RY11 [plasma membrane] (Homo sapiens)
Liganded Gq/11-activating GPCRs act as GEFs for Gq/11 (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
P2RY11 :ATP [plasma membrane] (Homo sapiens)
P2RY11 [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
P2RY11 :ATP [plasma membrane] (Homo sapiens)
P2RY11 [plasma membrane] (Homo sapiens)
The Ligand:GPCR:Gq complex dissociates (Homo sapiens)
GPCRs that activate Gq/11 [plasma membrane] (Homo sapiens)
P2RY11 [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
P2RY11 :ATP [plasma membrane] (Homo sapiens)
P2RY11 [plasma membrane] (Homo sapiens)
G alpha (s) signalling events (Homo sapiens)
Liganded Gs-activating GPCR acts as a GEF for Gs (Homo sapiens)
GPCR:ligand complexes that act on Gs:Heterotrimeric G-protein Gs (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
P2RY11 :ATP [plasma membrane] (Homo sapiens)
P2RY11 [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gs:Heterotrimeric G-protein Gs (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
P2RY11 :ATP [plasma membrane] (Homo sapiens)
P2RY11 [plasma membrane] (Homo sapiens)
Liganded Gs-activating GPCRs bind inactive heterotrimeric Gs (Homo sapiens)
Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
P2RY11 :ATP [plasma membrane] (Homo sapiens)
P2RY11 [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gs:Heterotrimeric G-protein Gs (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
P2RY11 :ATP [plasma membrane] (Homo sapiens)
P2RY11 [plasma membrane] (Homo sapiens)
The Ligand:GPCR:Gs complex dissociates (Homo sapiens)
GPCR:ligand complexes that act on Gs:Heterotrimeric G-protein Gs (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
P2RY11 :ATP [plasma membrane] (Homo sapiens)
P2RY11 [plasma membrane] (Homo sapiens)
GPCRs that activate Gs [plasma membrane] (Homo sapiens)
P2RY11 [plasma membrane] (Homo sapiens)
GPCR ligand binding (Homo sapiens)
Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
Nucleotide-like (purinergic) receptors (Homo sapiens)
P2Y receptors (Homo sapiens)
P2Y11 receptor can bind to ATP (Homo sapiens)
P2RY11 :ATP [plasma membrane] (Homo sapiens)
P2RY11 [plasma membrane] (Homo sapiens)
P2RY11 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q96G91 P2RY11
Gene Names
P2RY11
Chain
chain:1-374
Reference Genes
BioGPS Gene:5032 P2RY11
COSMIC (genes):P2RY11 P2RY11
CTD Gene:5032 P2RY11
dbSNP Gene:5032 P2RY11
ENSEMBL:ENSG00000244165 P2RY11
HGNC:8540 P2RY11
KEGG Gene (Homo sapiens):5032 P2RY11
Monarch:5032 P2RY11
NCBI Gene:5032 P2RY11
OMIM:602697 P2RY11
UCSC:Q96G91 P2RY11
Reference Transcript
RefSeq:NM_002566.4 P2RY11
Other Identifiers
0003140113
11728963_a_at
11754955_a_at
214546_s_at
33633_at
3820373
3820374
3820375
5032
A_23_P4696
A_33_P3239759
GE54234
GO:0003674
GO:0004930
GO:0005575
GO:0005886
GO:0005887
GO:0006950
GO:0006952
GO:0007165
GO:0007186
GO:0007190
GO:0007200
GO:0008150
GO:0016020
GO:0016021
GO:0019722
GO:0023041
GO:0030594
GO:0035589
GO:0038023
GO:0045031
GO:0071318
Hs.166168.0.S1_3p_s_at
ILMN_1752226
PH_hs_0031955
Participant Of
input
P2Y11 receptor can bind to ATP
hasMember
GPCRs that activate Gq/11 [plasma membrane]
GPCRs that activate Gs [plasma membrane]
hasComponent
P2RY11 :ATP [plasma membrane]
Inferred To
P2RY11 [plasma membrane] (Bos taurus)
P2RY11 [plasma membrane] (Sus scrofa)
tapbp [plasma membrane] (Xenopus tropicalis)
p2ry11 [plasma membrane] (Danio rerio)
Cross References
RefSeq
NP_002557.2
ZINC - World Drugs
P2Y11_HUMAN
OpenTargets
ENSG00000244165
ZINC - Substances
P2Y11_HUMAN
ZINC target
Q96G91
ZINC - Biogenic
P2Y11_HUMAN
PRO
Q96G91
PDB
2B6S
ZINC - Metabolites
P2Y11_HUMAN
GeneCards
Q96G91
HPA
ENSG00000244165-P2RY11
Ensembl
ENSP00000323872
,
ENSG00000244165
,
ENST00000321826
ZINC - Predictions - Purchasable
P2Y11_HUMAN
Orphanet
22534
HMDB Protein
HMDBP07862
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