Reactome | GPS1 [cytosol]

GPS1 [cytosol]

Stable Identifier

R-HSA-416972

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

COP9 signalosome complex subunit 1, CSN1_HUMAN

Locations in the PathwayBrowser

Expand all

Signal Transduction (Homo sapiens)

- Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Homo sapiens)
  - Signaling by Rho GTPases (Homo sapiens)
    - RHO GTPase cycle (Homo sapiens)
      - RHOBTB GTPase Cycle (Homo sapiens)
        
        RHOBTB1 GTPase cycle (Homo sapiens)
        
        RHOBTB1 binds interacting proteins at the endosome membrane (Homo sapiens)
        
        RHOBTB1 interacting proteins [cytosol] (Homo sapiens)
        
        GPS1 [cytosol] (Homo sapiens)
        
        RHOBTB1:GTP:RHOBTB1 interacting proteins [endosome membrane] (Homo sapiens)
        
        RHOBTB1 interacting proteins [cytosol] (Homo sapiens)
        
        GPS1 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q13098 GPS1

Gene Names

GPS1, COPS1, CSN1

Chain

initiator methionine:, chain:2-491

Reference Genes

BioGPS Gene:2873 GPS1

COSMIC (genes):GPS1 GPS1

CTD Gene:2873 GPS1

dbSNP Gene:2873 GPS1

ENSEMBL:ENSG00000169727 GPS1

ENSEMBL_homo_sapiens_GENE:ENSG00000169727.14 GPS1

HGNC:4549 GPS1

KEGG Gene (Homo sapiens):2873 GPS1

Monarch:2873 GPS1

NCBI Gene:2873 GPS1

OMIM:601934 GPS1

UCSC:Q13098 GPS1

Reference Transcript

Other Identifiers

11715535_a_at

16838988

217782_3p_s_at

217782_PM_s_at

217782_s_at

2873

3738493

3738494

3738495

3738496

3738497

3738498

3738501

3738502

3738503

3738504

3738505

3738507

3738508

3738509

3738511

3738513

3738515

3738517

3738519

3738520

3738521

3738522

3738523

73190_at

78787_at

8010747

A_23_P158662

GO:0000338

GO:0005095

GO:0005515

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0007254

GO:0008180

GO:0023052

GO:0032991

GO:0036211

GO:0043226

GO:0045116

GO:0098772

GO:2000434

HMNXSV003008519

ILMN_1769960

ILMN_1795876

PH_hs_0026722

TC17000945.hg

U20285_at

g13435380_3p_a_at

g13435380_3p_at

g13435380_3p_x_at

Participates

as a candidate of

RHOBTB1 interacting proteins [cytosol] (Homo sapiens)

as a component of

COP9 [cytosol] (Homo sapiens)

Other forms of this molecule

GPS1 [nucleoplasm]

Inferred To

GPS1 [cytosol] (Bos taurus)

GPS1 [cytosol] (Canis familiaris)

GPS1 [cytosol] (Gallus gallus)

GPS1 [cytosol] (Sus scrofa)

CSN1b [cytosol] (Drosophila melanogaster)

csn1 [cytosol] (Dictyostelium discoideum)

Gps1 [cytosol] (Mus musculus)

Gps1 [cytosol] (Rattus norvegicus)

Ghost homologue of GPS1 [cytosol] (Danio rerio)

csn-1 [cytosol] (Caenorhabditis elegans)

gps1 [cytosol] (Xenopus tropicalis)

Cross References

RefSeq

NP_997657.1, XP_016880023.1, NP_001308021.1, NP_004118.3

OpenTargets

ENSG00000169727

GeneCards

Q13098

HPA

ENSG00000169727-GPS1

Ensembl

ENSP00000376167, ENST00000578552, ENSG00000169727, ENST00000306823, ENST00000392358, ENSP00000302873, ENSP00000462265

PRO

Q13098

Pharos - Targets

Q13098

PDB

8H3A, 8H3F, 4D18, 6R6H, 6R7H, 8H38, 6R7N, 4D10, 4WSN, 6R7F, 6R7I

Interactors (3)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q15843 NEDD8	8	C111-AcM-UBE2M-G76-NEDD8 [nucleoplasm] (R-HSA-8952504) NEDD8 [nucleoplasm] (R-HSA-8955926) C116-AcM-UBE2F-G76-NEDD8 [cytosol] (R-HSA-8951739) NEDD8(77-81) [cytosol] (R-HSA-6782654) NEDD8(1-81) [cytosol] (R-HSA-5690794) C237-UBA3-G76-NEDD8 [cytosol] (R-HSA-8951647) NEDD8 [cytosol] (R-HSA-416969) C111-AcM-UBE2M-G76-NEDD8 [cytosol] (R-HSA-4419895)	0.592	6
UniProt:Q15831 STK11	2	STK11 [cytosol] (R-HSA-380954) STK11 [nucleoplasm] (R-HSA-164119)	0.527	2
UniProt:Q13616 CUL1	3	G76-NEDD8-K720-CUL1 [cytosol] (R-HSA-8952519) CUL1 [nucleoplasm] (R-HSA-187551) CUL1 [cytosol] (R-HSA-174230)	0.462	5