Reactome | NANS [cytosol]

NANS [cytosol]

Stable Identifier

R-HSA-4085396

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Sialic acid synthase, SIAS_HUMAN

Locations in the PathwayBrowser

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Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - Asparagine N-linked glycosylation (Homo sapiens)
    - Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein (Homo sapiens)
      - Synthesis of substrates in N-glycan biosythesis (Homo sapiens)
        
        Sialic acid metabolism (Homo sapiens)
        
        NANS converts ManNAc-6-P to Neu5Ac-9-P (Homo sapiens)
        
        NANS [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9NR45 NANS

Gene Names

NANS, SAS

Chain

initiator methionine:1, chain:2-359

Reference Genes

BioGPS Gene:54187 NANS

COSMIC (genes):NANS NANS

CTD Gene:54187 NANS

dbSNP Gene:54187 NANS

ENSEMBL:ENSG00000095380 NANS

HGNC:19237 NANS

KEGG Gene (Homo sapiens):54187 NANS

Monarch:54187 NANS

NCBI Gene:54187 NANS

OMIM:605202 NANS

UCSC:Q9NR45 NANS

Reference Transcript

RefSeq:NM_018946.3 NANS

Other Identifiers

0004590082

11716951_at

218189_s_at

3181465

3181466

3181467

3181474

3181476

3181477

3181478

3181481

3181482

3181483

54187

8156761

A_14_P110779

A_23_P9214

A_33_P3291776

GE62856

GO:0003674

GO:0003824

GO:0005575

GO:0005576

GO:0005615

GO:0005622

GO:0005737

GO:0005829

GO:0005975

GO:0006055

GO:0008150

GO:0008781

GO:0009058

GO:0016051

GO:0016740

GO:0016765

GO:0016779

GO:0034641

GO:0043226

GO:0044281

GO:0047444

GO:0050462

GO:0070062

GO:0070085

ILMN_1815874

PH_hs_0014165

TC09000497.hg

TC09002131.hg

g12056472_3p_at

Inferred To

Nans [cytosol] (Mus musculus)

Nans [cytosol] (Rattus norvegicus)

NANS [cytosol] (Bos taurus)

NANS [cytosol] (Canis familiaris)

NANS [cytosol] (Drosophila melanogaster)

NANS [cytosol] (Gallus gallus)

NANS [cytosol] (Sus scrofa)

nansa [cytosol] (Danio rerio)

nans [cytosol] (Xenopus tropicalis)

Cross References

RefSeq

NP_061819.2

OpenTargets

ENSG00000095380

HPA

ENSG00000095380-NANS

GeneCards

Q9NR45

Ensembl

ENSP00000210444, ENSG00000095380, ENST00000210444

PRO

Q9NR45

Orphanet

23779

HMDB Protein

HMDBP00333

PDB

1WVO

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