Signal peptidase hydrolyzes preproGLP-1 to proGLP-1

Stable Identifier
R-HSA-400459
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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The GCG (Proglucagon) mRNA is translated by ribosomes at the outer surface of the rough endoplasmic reticulum. The nascent peptide enters the endoplasmic reticulum through the translocon complex and the signal peptide is cleaved by the signal peptidase.

Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
serine-type endopeptidase activity of Signal Peptidase [endoplasmic reticulum membrane]
Physical Entity
Activity
Inferred From
Authored
Reviewed
Created
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