Signal peptidase hydrolyzes preproGLP-1 to proGLP-1

Stable Identifier
R-HSA-400459
Type
Reaction [transition]
Species
Homo sapiens
Compartment
endoplasmic reticulum lumen, endoplasmic reticulum membrane
ReviewStatus
5/5
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Signal peptidase hydrolyzes preproGLP-1 to proGLP-1
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The GCG (Proglucagon) mRNA is translated by ribosomes at the outer surface of the rough endoplasmic reticulum. The nascent peptide enters the endoplasmic reticulum through the translocon complex and the signal peptide is cleaved by the signal peptidase.
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Output
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as an event of
Catalyst Activity

serine-type endopeptidase activity of Signal Peptidase [endoplasmic reticulum membrane]

Physical Entity
Signal Peptidase [endoplasmic reticulum membrane] (Homo sapiens)
Activity
serine-type endopeptidase activity (GO:0004252)
Inferred From
Signal Peptidase (Canis) hydrolyzes the signal peptide of Preprolactin (Bos taurus)
Authored
May, B  (2009-05-19)
Reviewed
Bloom, SR  (2010-06-25)
Created
May, B  (2009-03-24)
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