Reactome | WNT5A and WNT11 bind FZD receptors to initiate Ca2+ signaling

WNT5A and WNT11 bind FZD receptors to initiate Ca2+ signaling

Stable Identifier

R-HSA-3965446

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane, extracellular region

ReviewStatus

5/5

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WNT5A and WNT11 bind FZD receptors to initiate Ca2+ signaling

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Binding of a number of 'non-canonical' WNT ligands, notably WNT5a and WNT11, to select FZD receptors has been shown to activate PLC and stimulate release of intracellular calcium stores (reviewed in De, 2011; Kuhl et al, 2000b). This WNT/Ca2+ pathway, which was first demonstrated in zebrafish and has subsequently been identified in Xenopus and human cells as well, activates CaMKII, PKC and calcineurin signaling (Slusarski et al, 1997a, b; Kuhl et al, 2000a, b; reviewed in Angers and Moon, 2009; Niehrs, 2012).

Literature References

PubMed ID	Title	Journal	Year
19536106	Proximal events in Wnt signal transduction Angers, S, Moon, RT	Nat Rev Mol Cell Biol	2009
9389482	Interaction of Wnt and a Frizzled homologue triggers G-protein-linked phosphatidylinositol signalling Slusarski, DC, Corces, VG, Moon, RT	Nature	1997
21903638	Wnt/Ca2+ signaling pathway: a brief overview De, A	Acta Biochim. Biophys. Sin. (Shanghai)	2011
10858654	The Wnt/Ca2+ pathway: a new vertebrate Wnt signaling pathway takes shape Kühl, M, Sheldahl, LC, Park, M, Miller, JR, Moon, RT	Trends Genet.	2000
9073455	Modulation of embryonic intracellular Ca2+ signaling by Wnt-5A Slusarski, DC, Yang-Snyder, J, Busa, WB, Moon, RT	Dev. Biol.	1997
23151663	The complex world of WNT receptor signalling Niehrs, C	Nat. Rev. Mol. Cell Biol.	2012