WNT5A and WNT11 bind FZD receptors to initiate Ca2+ signaling

Stable Identifier
R-HSA-3965446
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane, extracellular region
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WNT5A and WNT11 bind FZD receptors to initiate Ca2+ signaling
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Binding of a number of 'non-canonical' WNT ligands, notably WNT5a and WNT11, to select FZD receptors has been shown to activate PLC and stimulate release of intracellular calcium stores (reviewed in De, 2011; Kuhl et al, 2000b). This WNT/Ca2+ pathway, which was first demonstrated in zebrafish and has subsequently been identified in Xenopus and human cells as well, activates CaMKII, PKC and calcineurin signaling (Slusarski et al, 1997a, b; Kuhl et al, 2000a, b; reviewed in Angers and Moon, 2009; Niehrs, 2012).

Literature References
PubMed ID Title Journal Year
9389482 Interaction of Wnt and a Frizzled homologue triggers G-protein-linked phosphatidylinositol signalling

Slusarski, DC, Corces, VG, Moon, RT

Nature 1997
19536106 Proximal events in Wnt signal transduction

Angers, S, Moon, RT

Nat Rev Mol Cell Biol 2009
21903638 Wnt/Ca2+ signaling pathway: a brief overview

De, A

Acta Biochim. Biophys. Sin. (Shanghai) 2011
10858654 The Wnt/Ca2+ pathway: a new vertebrate Wnt signaling pathway takes shape

Kühl, M, Sheldahl, LC, Park, M, Miller, JR, Moon, RT

Trends Genet. 2000
9073455 Modulation of embryonic intracellular Ca2+ signaling by Wnt-5A

Slusarski, DC, Yang-Snyder, J, Busa, WB, Moon, RT

Dev. Biol. 1997
23151663 The complex world of WNT receptor signalling

Niehrs, C

Nat. Rev. Mol. Cell Biol. 2012
Participants
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Participant Of
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Inferred From
Wnt5a/11b bind Ca2+ Fzd receptors (Homo sapiens)
Authored
Rothfels, K  (2013-07-10)
Reviewed
Kikuchi, A  (2013-11-13)
Created
Rothfels, K  (2013-07-23)