WNT5A and WNT11 bind FZD receptors to initiate Ca2+ signaling

Stable Identifier
Reaction [binding]
Homo sapiens
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Binding of a number of 'non-canonical' WNT ligands, notably WNT5a and WNT11, to select FZD receptors has been shown to activate PLC and stimulate release of intracellular calcium stores (reviewed in De, 2011; Kuhl et al, 2000b). This WNT/Ca2+ pathway, which was first demonstrated in zebrafish and has subsequently been identified in Xenopus and human cells as well, activates CaMKII, PKC and calcineurin signaling (Slusarski et al, 1997a, b; Kuhl et al, 2000a, b; reviewed in Angers and Moon, 2009; Niehrs, 2012).

Literature References
PubMed ID Title Journal Year
19536106 Proximal events in Wnt signal transduction

Angers, S, Moon, RT

Nat Rev Mol Cell Biol 2009
9389482 Interaction of Wnt and a Frizzled homologue triggers G-protein-linked phosphatidylinositol signalling

Corces, VG, Slusarski, DC, Moon, RT

Nature 1997
21903638 Wnt/Ca2+ signaling pathway: a brief overview

De, A

Acta Biochim. Biophys. Sin. (Shanghai) 2011
10858654 The Wnt/Ca2+ pathway: a new vertebrate Wnt signaling pathway takes shape

Sheldahl, LC, Kühl, M, Moon, RT, Miller, JR, Park, M

Trends Genet. 2000
9073455 Modulation of embryonic intracellular Ca2+ signaling by Wnt-5A

Yang-Snyder, J, Busa, WB, Moon, RT, Slusarski, DC

Dev. Biol. 1997
23151663 The complex world of WNT receptor signalling

Niehrs, C

Nat. Rev. Mol. Cell Biol. 2012
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