Binding of a number of 'non-canonical' WNT ligands, notably WNT5a and WNT11, to select FZD receptors has been shown to activate PLC and stimulate release of intracellular calcium stores (reviewed in De, 2011; Kuhl et al, 2000b). This WNT/Ca2+ pathway, which was first demonstrated in zebrafish and has subsequently been identified in Xenopus and human cells as well, activates CaMKII, PKC and calcineurin signaling (Slusarski et al, 1997a, b; Kuhl et al, 2000a, b; reviewed in Angers and Moon, 2009; Niehrs, 2012).
Slusarski, DC, Corces, VG, Moon, RT
Angers, S, Moon, RT
De, A
Kühl, M, Sheldahl, LC, Park, M, Miller, JR, Moon, RT
Slusarski, DC, Yang-Snyder, J, Busa, WB, Moon, RT
Niehrs, C
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