Wnt5a/11b bind Ca2+ Fzd receptors

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Homo sapiens
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Wnt5a/11b bind Ca2+ Fzd receptors

Stimulation of intracellular calcium release has been demonstrated in Xenopus embryos expressing rat Fzd2 and mouse Fzd 3, 4 and 6 in response to XWnt5a and XWnt11 (Kuhl et al, 2000a, b), as well as in a variety of human cancer and immune cell lines in response to FZD5 (Blumenthal et al, 2006; Pereira et al, 2008; Dissanayake et al, 2007; Weeraratna et al, 2002, Demjek et al, 2006).

Literature References
PubMed ID Title Journal Year
16601243 The Wingless homolog WNT5A and its receptor Frizzled-5 regulate inflammatory responses of human mononuclear cells induced by microbial stimulation

Blumenthal, A, Ehlers, S, Lauber, J, Buer, J, Lange, C, Goldmann, T, Heine, H, Brandt, E, Reiling, N

Blood 2006
16880514 Wnt-5a/Ca2+-induced NFAT activity is counteracted by Wnt-5a/Yes-Cdc42-casein kinase 1alpha signaling in human mammary epithelial cells

Dejmek, J, Säfholm, A, Kamp Nielsen, C, Andersson, T, Leandersson, K

Mol. Cell. Biol. 2006
18174455 Wnt5A/CaMKII signaling contributes to the inflammatory response of macrophages and is a target for the antiinflammatory action of activated protein C and interleukin-10

Pereira, C, Schaer, DJ, Bachli, EB, Kurrer, MO, Schoedon, G

Arterioscler. Thromb. Vasc. Biol. 2008
17426020 The Wnt5A/protein kinase C pathway mediates motility in melanoma cells via the inhibition of metastasis suppressors and initiation of an epithelial to mesenchymal transition

Dissanayake, SK, Wade, M, Johnson, CE, O'Connell, MP, Leotlela, PD, French, AD, Shah, KV, Hewitt, KJ, Rosenthal, DT, Indig, FE, Jiang, Y, Nickoloff, BJ, Taub, DD, Trent, JM, Moon, RT, Bittner, M, Weeraratna, AT

J. Biol. Chem. 2007
12086864 Wnt5a signaling directly affects cell motility and invasion of metastatic melanoma

Weeraratna, AT, Jiang, Y, Hostetter, G, Rosenblatt, K, Duray, P, Bittner, M, Trent, JM

Cancer Cell 2002
10777564 Ca(2+)/calmodulin-dependent protein kinase II is stimulated by Wnt and Frizzled homologs and promotes ventral cell fates in Xenopus

Kühl, M, Sheldahl, LC, Malbon, CC, Moon, RT

J. Biol. Chem. 2000
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