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p-S154,T436-PAK3 [plasma membrane]
Stable Identifier
R-HSA-3928479
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
phospho-PAK3, p-PAK3
Locations in the PathwayBrowser
Expand all
Developmental Biology (Homo sapiens)
Nervous system development (Homo sapiens)
Axon guidance (Homo sapiens)
EPH-Ephrin signaling (Homo sapiens)
Ephrin signaling (Homo sapiens)
PAKs autophosphorylate (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP:p-PAK1,3 [plasma membrane] (Homo sapiens)
p-PAK1/3, 2 [plasma membrane] (Homo sapiens)
p-S154,T436-PAK3 [plasma membrane] (Homo sapiens)
PAKs phosphorylate MLC (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP:p-PAK1,3 [plasma membrane] (Homo sapiens)
p-PAK1/3, 2 [plasma membrane] (Homo sapiens)
p-S154,T436-PAK3 [plasma membrane] (Homo sapiens)
p-PAK1/3, 2 [plasma membrane] (Homo sapiens)
p-S154,T436-PAK3 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:O75914 PAK3
Gene Names
PAK3, OPHN3
Chain
chain:1-559
Reference Genes
BioGPS Gene:5063 PAK3
COSMIC (genes):PAK3 PAK3
CTD Gene:5063 PAK3
dbSNP Gene:5063 PAK3
ENSEMBL:ENSG00000077264 PAK3
HGNC:8592 PAK3
KEGG:hsa:5063 PAK3
Monarch:5063 PAK3
NCBI Gene:5063 PAK3
OMIM:300142 PAK3
UCSC:O75914 PAK3
Reference Transcript
RefSeq:NM_002578.5 PAK3
RefSeq:NM_001324330.2 PAK3
RefSeq:NM_001128168.3 PAK3
RefSeq:NM_001324327.2 PAK3
RefSeq:NM_001324325.2 PAK3
RefSeq:NM_001324332.2 PAK3
RefSeq:NM_001128172.2 PAK3
RefSeq:NM_001324334.2 PAK3
RefSeq:XM_017029557.2 PAK3
RefSeq:NM_001324326.2 PAK3
RefSeq:XM_047442148.1 PAK3
RefSeq:NM_001324328.2 PAK3
RefSeq:XM_047442149.1 PAK3
RefSeq:NM_001128167.3 PAK3
RefSeq:NM_001324329.2 PAK3
RefSeq:NM_001324331.2 PAK3
RefSeq:NM_001324333.2 PAK3
RefSeq:NM_001128173.3 PAK3
RefSeq:XM_054327159.1 PAK3
RefSeq:XM_054327152.1 PAK3
RefSeq:NM_001128166.3 PAK3
RefSeq:XM_054327162.1 PAK3
RefSeq:XM_054327160.1 PAK3
RefSeq:XM_017029561.1 PAK3
RefSeq:XM_017029563.2 PAK3
Other Identifiers
11732741_a_at
11741759_a_at
17106214
214607_PM_at
214607_at
229201_PM_at
229201_at
33073_at
33074_g_at
3987234
3987246
3987263
3987265
3987266
3987267
3987268
3987269
3987274
3987275
3987276
3987277
3987278
3987279
3987283
3987284
3987291
3987292
3987306
3987308
3987309
3987310
3987311
3987312
3987316
3987317
3987318
3987325
3987327
3987328
3987330
3987332
3987339
3987343
3987344
3987345
3987347
3987349
3987351
3987353
3987355
47494_at
5063
72624_at
8169389
A_14_P104145
A_14_P139885
A_23_P346813
A_32_P212483
A_33_P3384337
GE492007
GE54615
GO:0000165
GO:0002223
GO:0002376
GO:0003824
GO:0004672
GO:0004674
GO:0004676
GO:0004677
GO:0004679
GO:0004694
GO:0004708
GO:0004711
GO:0005515
GO:0005524
GO:0005737
GO:0005829
GO:0005886
GO:0006325
GO:0006338
GO:0006468
GO:0007409
GO:0009267
GO:0014069
GO:0016358
GO:0016477
GO:0016740
GO:0017124
GO:0030833
GO:0031267
GO:0032956
GO:0034330
GO:0035175
GO:0035402
GO:0035403
GO:0035556
GO:0035979
GO:0043226
GO:0043408
GO:0044022
GO:0044023
GO:0044024
GO:0044025
GO:0046872
GO:0048013
GO:0048856
GO:0048870
GO:0050770
GO:0050808
GO:0060996
GO:0060997
GO:0072354
GO:0072371
GO:0072518
GO:0098978
GO:0099175
GO:0106310
GO:0140096
GO:0140823
GO:0140855
GO:0140857
GO:1990244
HMNXSV003000905
HMNXSV003046757
Hs.13326.0.A1_3p_at
Hs.152663.0.S2_3p_at
ILMN_1743358
ILMN_2130218
PH_hs_0019287
TC0X000543.hg
Participates
as a member of
p-PAK1/3, 2 [plasma membrane] (Homo sapiens)
Other forms of this molecule
PAK3 [cytosol]
p-S154,T436-PAK3 [cytosol]
Inferred To
phospho-PAK3 [plasma membrane]
(Bos taurus)
phospho-PAK3 [plasma membrane]
(Canis familiaris)
phospho-PAK3 [plasma membrane]
(Gallus gallus)
phospho-pak3 [plasma membrane]
(Xenopus tropicalis)
phospho-max-2 [plasma membrane]
(Caenorhabditis elegans)
phospho-Pak3 [plasma membrane]
(Drosophila melanogaster)
phospho-Pak3 [plasma membrane]
(Mus musculus)
phospho-Pak3 [plasma membrane]
(Rattus norvegicus)
Homologues of p-S154,T436-PAK3 [plasma membrane]
(Caenorhabditis elegans)
Homologues of p-S154,T436-PAK3 [plasma membrane]
(Drosophila melanogaster)
phospho-Pak [plasma membrane]
(Drosophila melanogaster)
phospho-pak-1 [plasma membrane]
(Caenorhabditis elegans)
Modified Residues
Name
O-phospho-L-serine at 154
Coordinate
154
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-threonine at 436
Coordinate
436
PsiMod Name
O-phospho-L-threonine [MOD:00047]
PsiMod Definition
A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.
Cross References
RefSeq
XP_047298104.1
,
NP_001311254.1
,
NP_001311256.1
,
XP_016885050.1
,
XP_047298105.1
,
NP_001311255.1
,
NP_001121640.1
,
XP_016885046.1
,
NP_001311259.1
,
NP_001311257.1
,
XP_016885052.1
,
NP_001121644.1
,
NP_001121645.1
,
NP_001311258.1
,
XP_054183127.1
,
XP_054183137.1
,
NP_002569.1
,
NP_001311263.1
,
NP_001311261.1
,
NP_001311262.1
,
NP_001311260.1
,
XP_054183134.1
,
NP_001121638.1
,
XP_054183135.1
,
NP_001121639.1
ZINC - World Drugs
PAK3_HUMAN
Guide to Pharmacology - Targets
2135
OpenTargets
ENSG00000077264
ENSEMBL
ENST00000446737
,
ENST00000360648
,
ENST00000417227
,
ENSP00000262836
,
ENST00000518291
,
ENST00000519681
,
ENST00000372010
,
ENSP00000389172
,
ENSP00000428921
,
ENSP00000401982
,
ENSP00000361080
,
ENSP00000429113
,
ENSP00000361077
,
ENST00000425146
,
ENSP00000353864
,
ENST00000262836
,
ENSP00000410853
,
ENST00000372007
,
ENSG00000077264
ZINC - FDA approved
PAK3_HUMAN
ZINC - Substances
PAK3_HUMAN
ZINC - Biogenic
PAK3_HUMAN
ZINC target
O75914
PRO
O75914
GlyGen
O75914
PDB
6FD3
ZINC - Investigational
PAK3_HUMAN
HPA
ENSG00000077264-PAK3
GeneCards
PAK3
Pharos - Targets
O75914
Orphanet
PAK3
ZINC - Predictions - Purchasable
PAK3_HUMAN
HMDB Protein
HMDBP01400
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O14907 TAX1BP3
1
TAX1BP3 [cytosol]
(R-HSA-5666217)
0.527
3
UniProt:P60953-2 CDC42
0.508
2
UniProt:P63000 RAC1
6
RAC1 [plasma membrane]
(R-HSA-351141)
RAC1 [cytosol]
(R-HSA-442615)
GGC-PalmC-RAC1 [plasma membrane]
(R-HSA-2316446)
RAC1 [secretory granule membrane]
(R-HSA-6804770)
RAC1 [ficolin-1-rich granule membrane]
(R-HSA-6804802)
RAC1 [endoplasmic reticulum membrane]
(R-HSA-5672076)
0.471
2
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