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PTGFR [plasma membrane]
Stable Identifier
R-HSA-391826
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
FP receptor, RecName: Full=Prostaglandin F2-alpha receptor; Short=PGF2 alpha receptor; AltName: Full=Prostanoid FP receptor; AltName: Full=PGF receptor;
GN Name=PTGFR;
OS Homo sapiens, PF2R_HUMAN
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (q) signalling events (Homo sapiens)
Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
PTGFR:PGF2a [plasma membrane] (Homo sapiens)
PTGFR [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
PTGFR:PGF2a [plasma membrane] (Homo sapiens)
PTGFR [plasma membrane] (Homo sapiens)
Liganded Gq/11-activating GPCRs act as GEFs for Gq/11 (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
PTGFR:PGF2a [plasma membrane] (Homo sapiens)
PTGFR [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
PTGFR:PGF2a [plasma membrane] (Homo sapiens)
PTGFR [plasma membrane] (Homo sapiens)
The Ligand:GPCR:Gq complex dissociates (Homo sapiens)
GPCRs that activate Gq/11 [plasma membrane] (Homo sapiens)
PTGFR [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
PTGFR:PGF2a [plasma membrane] (Homo sapiens)
PTGFR [plasma membrane] (Homo sapiens)
GPCR ligand binding (Homo sapiens)
Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
Eicosanoid ligand-binding receptors (Homo sapiens)
Prostanoid ligand receptors (Homo sapiens)
PTGFR binds PGF2a (Homo sapiens)
PTGFR [plasma membrane] (Homo sapiens)
PTGFR:PGF2a [plasma membrane] (Homo sapiens)
PTGFR [plasma membrane] (Homo sapiens)
PTGFR binds PTGFR agonists (Homo sapiens)
PTGFR [plasma membrane] (Homo sapiens)
PTGFR:PTGFR agonists [plasma membrane] (Homo sapiens)
PTGFR [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P43088 PTGFR
Gene Names
PTGFR
Chain
chain:1-359
Reference Genes
BioGPS Gene:5737 PTGFR
COSMIC - genes:PTGFR PTGFR
CTD Gene:5737 PTGFR
dbSNP Gene:5737 PTGFR
ENSEMBL:ENSG00000122420 PTGFR
HGNC:9600 PTGFR
KEGG:hsa:5737 PTGFR
Monarch:5737 PTGFR
NCBI Gene:5737 PTGFR
OMIM:600563 PTGFR
UCSC:P43088 PTGFR
Reference Transcript
RefSeq:XM_047426085.1 PTGFR
RefSeq:NM_001039585.2 PTGFR
RefSeq:NM_000959.4 PTGFR
RefSeq:XM_054337810.1 PTGFR
RefSeq:XM_054337809.1 PTGFR
RefSeq:XM_017001873.1 PTGFR
Other Identifiers
11734179_a_at
11734180_a_at
11740585_a_at
11740586_a_at
1555097_PM_a_at
1555097_a_at
16666471
207177_PM_at
207177_at
2343287
2343288
2343419
2343420
2343421
2343422
2343423
2343424
2343425
2343426
2343427
2343428
2343434
2343435
2343436
2343437
2343438
2343439
2343455
2343456
2343457
34015_at
5737
7902527
A_23_P11674
A_24_P302172
A_33_P3358183
A_33_P3376546
A_33_P3376551
GE54054
GO:0004930
GO:0004958
GO:0005576
GO:0005737
GO:0005886
GO:0006954
GO:0007165
GO:0007186
GO:0007189
GO:0007204
GO:0007567
GO:0008284
GO:0010628
GO:0016020
GO:0022414
GO:0032355
GO:0032496
GO:0033993
GO:0043066
GO:0071799
HMNXSV003028222
HMNXSV003048331
Hs2.89418.2.S1_3p_s_at
ILMN_1813341
ILMN_2395652
L24470_at
TC01000792.hg
g4506260_3p_at
Participates
as an input of
PTGFR binds PGF2a (Homo sapiens)
PTGFR binds PTGFR agonists (Homo sapiens)
as a component of
PTGFR:PTGFR agonists [plasma membrane] (Homo sapiens)
PTGFR:PGF2a [plasma membrane] (Homo sapiens)
as a member of
GPCRs that activate Gq/11 [plasma membrane] (Homo sapiens)
Inferred To
PTGFR [plasma membrane]
(Bos taurus)
PTGFR [plasma membrane]
(Canis familiaris)
PTGFR [plasma membrane]
(Gallus gallus)
PTGFR [plasma membrane]
(Sus scrofa)
ptgfr [plasma membrane]
(Danio rerio)
ptgfr [plasma membrane]
(Xenopus tropicalis)
Pgr [plasma membrane]
(Drosophila melanogaster)
Ptgfr [plasma membrane]
(Mus musculus)
Ptgfr [plasma membrane]
(Rattus norvegicus)
Cross References
RefSeq
NP_000950.1
,
XP_054193784.1
,
XP_047282041.1
,
NP_001034674.1
,
XP_054193785.1
,
XP_016857362.1
ZINC - World Drugs
PF2R_HUMAN
Guide to Pharmacology - Targets
344
OpenTargets
ENSG00000122420
ENSEMBL
ENSG00000122420
,
ENST00000370757
,
ENST00000370758
,
ENSP00000359794
,
ENSP00000359793
,
ENSP00000359792
,
ENST00000370756
ZINC - Substances
PF2R_HUMAN
ZINC - Biogenic
PF2R_HUMAN
ZINC target
P43088
PRO
P43088
GlyGen
P43088
PDB
8IQ6
,
8IUK
,
8IUM
,
8XJK
,
8XJM
,
8IUL
,
8XJL
,
8IQ4
ZINC - Metabolites
PF2R_HUMAN
HPA
ENSG00000122420-PTGFR
GeneCards
PTGFR
Pharos - Targets
P43088
ZINC - Predictions - Purchasable
PF2R_HUMAN
HMDB Protein
HMDBP01950
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9BT67 NFIP1
0.527
2
UniProt:Q08357 SLC20A2
7
SLC20A2 [plasma membrane]
(R-HSA-427661)
SLC20A2 G498R [plasma membrane]
(R-HSA-5625140)
SLC20A2 S601L [plasma membrane]
(R-HSA-5625095)
SLC20A2 T595M [plasma membrane]
(R-HSA-5625111)
SLC20A2 S610Afs*17 [plasma membrane]
(R-HSA-5625137)
SLC20A2 L170* [plasma membrane]
(R-HSA-5625074)
SLC20A2 V195Lfs*61 [plasma membrane]
(R-HSA-5625150)
0.527
2
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