Reactome | PTGFR binds PTGFR agonists

PTGFR binds PTGFR agonists

Stable Identifier

R-HSA-9718020

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane, extracellular region

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

Signal Transduction (Homo sapiens)

- Signaling by GPCR (Homo sapiens)
  - GPCR ligand binding (Homo sapiens)
    - Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
      - Eicosanoid ligand-binding receptors (Homo sapiens)
        
        Prostanoid ligand receptors (Homo sapiens)
        
        PTGFR binds PTGFR agonists (Homo sapiens)

General

SBML | | PDF

SVG | | PPTX | SBGN

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

The prostaglandin F receptor (PTGFR) is a prostenoid receptor based on its ability, upon activation by prostaglandin F2α, to contract certain smooth muscle and smooth muscle-containing tissues such as those of the uterus and the eye. PTGFR is highly expressed in the uterine myometrium, the eye and the ovaries. PTGFR agonists (Abramovitz et al. 2000, Sharif et al. 2001, 2002, Neuschäfer-Rube et al. 2003) are primarily used to treat ocular hypertension and gluacoma, as well as eyelash hypotrichosis due to the autoimmune disease alopecia areata. The free acid forms of bimatoprost, latanoprost, tafluprost and travoprost (fluprostenol) are the active forms which are indicated for glaucoma and ocular hypertension. Latanoprostene bunod is a NO-donating analogue of the prostaglandin F2α agonist latanoprost (isopropyl ester) and benefits from the additive hypotensive actions of both the prostaglandin agonist and NO (determined in preclinical models, Kraus et al. 2011). Latanoprostene bunod is the first NO-donating prostaglandin analogue to be granted FDA marketing approval (Kaufman 2017, Fingeret et al. 2019).

Literature References

PubMed ID	Title	Journal	Year
11740958	Bimatoprost and its free acid are prostaglandin FP receptor agonists Kelly, CR, Williams, GW, Sharif, NA	Eur J Pharmacol	2001
12222762	Agonist activity of bimatoprost, travoprost, latanoprost, unoprostone isopropyl ester and other prostaglandin analogs at the cloned human ciliary body FP prostaglandin receptor Crider, JY, Kelly, CR, Sharif, NA	J Ocul Pharmacol Ther	2002
12519077	Identification by site-directed mutagenesis of amino acids contributing to ligand-binding specificity or signal transduction properties of the human FP prostanoid receptor Böer, U, Koch, S, Püschel, GP, Engemaier, E, Neuschäfer-Rube, F	Biochem. J.	2003
10634944	The utilization of recombinant prostanoid receptors to determine the affinities and selectivities of prostaglandins and related analogs Adam, M, Labelle, M, Abramovitz, M, Gareau, Y, Sawyer, N, Denis, D, Belley, M, Lamontagne, S, Boie, Y, Metters, KM, Godbout, C, Rochette, C, Tremblay, NM, Dufresne, C, Ouimet, N, Gallant, M, Ruel, R, Carrière, M, Juteau, H	Biochim. Biophys. Acta	2000