Reactome | PTGFR binds PGF2a

PTGFR binds PGF2a

Stable Identifier

R-HSA-416929

Type

Reaction [binding]

Species

Homo sapiens

Compartment

extracellular region, plasma membrane

ReviewStatus

5/5

Locations in the PathwayBrowser

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Signal Transduction (Homo sapiens)

- Signaling by GPCR (Homo sapiens)
  - GPCR ligand binding (Homo sapiens)
    - Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
      - Eicosanoid ligand-binding receptors (Homo sapiens)
        
        Prostanoid ligand receptors (Homo sapiens)
        
        PTGFR binds PGF2a (Homo sapiens)

General

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Prostaglandin F receptor (FP) is a GPCR for Prostaglandin F2alpha and is encoded by the PTGFR gene (Abramovitz M et al, 1994). Main effects of prostaglandin binding to the receptor are uterine contraction and bronchoconstriction. These effects are mediated by coupling with the G protein alpha q/11 subunit which activates a phosphatidylinositol-calcium second messenger system (Carrasco MP et al, 1997).

Literature References

PubMed ID	Title	Journal	Year
9462300	Activation of the prostaglandin FP receptor in human granulosa cells Carrasco, MP, López Bernal, A, Asbóth, G, Phaneuf, S	J Reprod Fertil	1997
8300593	Cloning and expression of a cDNA for the human prostanoid FP receptor Rushmore, TH, Nguyen, T, Slipetz, DM, Boie, Y, Bayne, MA, Abramovitz, M, Grygorczyk, R, Metters, KM	J Biol Chem	1994