FP receptor can bind PGF2-alpha

Stable Identifier
Reaction [binding]
Homo sapiens
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Prostaglandin F receptor (FP) is a GPCR for Prostaglandin F2alpha and is encoded by the PTGFR gene (Abramovitz M et al, 1994). Main effects of prostaglandin binding to the receptor are uterine contraction and bronchoconstriction. These effects are mediated by coupling with the G protein alpha q/11 subunit which activates a phosphatidylinositol-calcium second messenger system (Carrasco MP et al, 1997).

Literature References
PubMed ID Title Journal Year
8300593 Cloning and expression of a cDNA for the human prostanoid FP receptor

Abramovitz, M, Boie, Y, Nguyen, T, Rushmore, TH, Bayne, MA, Metters, KM, Slipetz, DM, Grygorczyk, R

J Biol Chem 1994
9462300 Activation of the prostaglandin FP receptor in human granulosa cells

Carrasco, MP, Asbóth, G, Phaneuf, S, López Bernal, A

J Reprod Fertil 1997
Participant Of
Orthologous Events
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