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OPN4 [photoreceptor disc membrane]
Stable Identifier
R-HSA-391825
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
photoreceptor disc membrane
Synonyms
Melanopsin, Opsin-4, RecName: Full=Melanopsin; AltName: Full=Opsin-4;
GN Name=OPN4; Synonyms=MOP;
OS Homo sapiens, OPN4_HUMAN
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (q) signalling events (Homo sapiens)
Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
Melanospin:photon [photoreceptor disc membrane] (Homo sapiens)
OPN4 [photoreceptor disc membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
Melanospin:photon [photoreceptor disc membrane] (Homo sapiens)
OPN4 [photoreceptor disc membrane] (Homo sapiens)
Liganded Gq/11-activating GPCRs act as GEFs for Gq/11 (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
Melanospin:photon [photoreceptor disc membrane] (Homo sapiens)
OPN4 [photoreceptor disc membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
Melanospin:photon [photoreceptor disc membrane] (Homo sapiens)
OPN4 [photoreceptor disc membrane] (Homo sapiens)
The Ligand:GPCR:Gq complex dissociates (Homo sapiens)
GPCRs that activate Gq/11 [plasma membrane] (Homo sapiens)
OPN4 [photoreceptor disc membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
Melanospin:photon [photoreceptor disc membrane] (Homo sapiens)
OPN4 [photoreceptor disc membrane] (Homo sapiens)
GPCR ligand binding (Homo sapiens)
Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
Opsins (Homo sapiens)
Melanospin is stimulated by light (Homo sapiens)
Melanospin:photon [photoreceptor disc membrane] (Homo sapiens)
OPN4 [photoreceptor disc membrane] (Homo sapiens)
OPN4 [photoreceptor disc membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9UHM6 OPN4
Gene Names
OPN4, MOP
Chain
chain:1-478
Reference Genes
BioGPS Gene:94233 OPN4
COSMIC (genes):OPN4 OPN4
CTD Gene:94233 OPN4
dbSNP Gene:94233 OPN4
ENSEMBL:ENSG00000122375.13 OPN4
HGNC:14449 OPN4
KEGG Gene (Homo sapiens):94233 OPN4
Monarch:94233 OPN4
NCBI Gene:94233 OPN4
OMIM:606665 OPN4
UCSC:Q9UHM6 OPN4
Reference Transcript
RefSeq:NM_001030015.2 OPN4
RefSeq:NM_033282.3 OPN4
Other Identifiers
0001780601
11740783_a_at
16706835
234226_PM_at
234226_at
3255939
3255940
3255944
3255946
3255947
3255948
3255950
3255951
3255953
3255954
3255955
3255958
3255960
3255961
3255965
3255966
3255967
3255968
3255969
7928823
94233
A_14_P102051
A_23_P24234
GE83638
GO:0004930
GO:0005502
GO:0005515
GO:0005886
GO:0005887
GO:0005929
GO:0007165
GO:0007186
GO:0007601
GO:0007602
GO:0007634
GO:0008020
GO:0008289
GO:0009584
GO:0009881
GO:0016020
GO:0016021
GO:0023052
GO:0030424
GO:0030425
GO:0042752
GO:0042995
GO:0043052
GO:0043204
GO:0043226
GO:0048511
GO:0048856
GO:0050877
GO:0050896
GO:0050960
GO:0060089
GO:0071482
GO:0097381
GO:1990384
GO:1990913
HMNXSV003045197
Hs.283922.0.S1_3p_at
ILMN_1713029
ILMN_2394106
PH_hs_0014700
TC10002187.hg
TC10002926.hg
Participates
as an input of
Melanospin is stimulated by light (Homo sapiens)
as a member of
GPCRs that activate Gq/11 [plasma membrane] (Homo sapiens)
as a component of
Melanospin:photon [photoreceptor disc membrane] (Homo sapiens)
Inferred To
OPN4 [photoreceptor disc membrane]
(Bos taurus)
OPN4 [photoreceptor disc membrane]
(Caenorhabditis elegans)
OPN4 [photoreceptor disc membrane]
(Canis familiaris)
OPN4 [photoreceptor disc membrane]
(Gallus gallus)
OPN4 [photoreceptor disc membrane]
(Sus scrofa)
Opn4 [photoreceptor disc membrane]
(Mus musculus)
Opn4 [photoreceptor disc membrane]
(Rattus norvegicus)
opn4a [photoreceptor disc membrane]
(Danio rerio)
Rh3 [photoreceptor disc membrane]
(Drosophila melanogaster)
opn4 [photoreceptor disc membrane]
(Xenopus tropicalis)
Cross References
RefSeq
NP_001025186.1
,
NP_150598.1
Guide to Pharmacology - Targets
2758
OpenTargets
ENSG00000122375
GeneCards
Q9UHM6
HPA
ENSG00000122375-OPN4
Ensembl
ENST00000241891
,
ENSG00000122375
,
ENST00000372071
,
ENSP00000361141
,
ENSP00000241891
PRO
Q9UHM6
Pharos - Targets
Q9UHM6
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9UHD9 UBQLN2
1
UBQLN2 [cytosol]
(R-HSA-8866007)
0.556
3
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