Melanospin is stimulated by light

Stable Identifier
R-HSA-419861
Type
Reaction [binding]
Species
Homo sapiens
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Melanopsin (Opsin-4) (Provencio I et al, 2000) is a member of the opsin family encoded by the OPN4 gene. It is found in specialized photosensitive ganglion cells of the retina that are involved in the regulation of circadian rhythms, pupillary light reflex, and other non-visual responses to light. Melanopsin is expressed only in the retina and there, only in 1-2% of the ganglion cells. The effects of melanopsin are mediated by coupling to Gq/11 proteins which results in increased intracellular calcium levels (Qiu X et al, 2005).

Literature References
PubMed ID Title Journal Year
15674243 Induction of photosensitivity by heterologous expression of melanopsin

Qiu, X, Kumbalasiri, T, Carlson, SM, Wong, KY, Krishna, V, Provencio, I, Berson, DM

Nature 2005
10632589 A novel human opsin in the inner retina

Provencio, I, Rodriguez, IR, Jiang, G, Hayes, WP, Moreira, EF, Rollag, MD

J Neurosci 2000
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