Reactome | Melanospin is stimulated by light

Melanospin is stimulated by light

Stable Identifier

R-HSA-419861

Type

Reaction [binding]

Species

Homo sapiens

Compartment

extracellular region, plasma membrane

ReviewStatus

5/5

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Melanopsin (Opsin-4) (Provencio I et al, 2000) is a member of the opsin family encoded by the OPN4 gene. It is found in specialized photosensitive ganglion cells of the retina that are involved in the regulation of circadian rhythms, pupillary light reflex, and other non-visual responses to light. Melanopsin is expressed only in the retina and there, only in 1-2% of the ganglion cells. The effects of melanopsin are mediated by coupling to Gq/11 proteins which results in increased intracellular calcium levels (Qiu X et al, 2005).

Literature References

PubMed ID	Title	Journal	Year
10632589	A novel human opsin in the inner retina Provencio, I, Rodriguez, IR, Jiang, G, Hayes, WP, Moreira, EF, Rollag, MD	J Neurosci	2000
15674243	Induction of photosensitivity by heterologous expression of melanopsin Qiu, X, Kumbalasiri, T, Carlson, SM, Wong, KY, Krishna, V, Provencio, I, Berson, DM	Nature	2005