Gonadotropin-releasing hormone receptors can bind GNRH I and II

Stable Identifier
Reaction [binding]
Homo sapiens
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Luteinizing hormone releasing hormone (LHRH, also termed gonadotropin releasing hormone GnRH), is a decapeptide involved in the control of human reproduction. There are two genes, LHRH I and II which encode two hormones (Seeburg PH and Adelman JP, 1984; White RB et al, 1998). They are produced by hypothalamic neurones and mediates the release of luteinizing hormone (LH) and follicle stimulating hormone (FSH) from gonadotropic cells in the anterior pituitary. Their effects are mediated by binding to the gonadotropin-releasing hormone receptors 1 and 2 (GnRHR) (Kakar SS et al, 1992; Faurholm B et al, 2001) which couple with the G protein alpha-q/11 subunit.

Literature References
PubMed ID Title Journal Year
1333190 Cloning, sequencing, and expression of human gonadotropin releasing hormone (GnRH) receptor

Kakar, SS, Musgrove, LC, Devor, DC, Sellers, JC, Neill, JD

Biochem Biophys Res Commun 1992
6090951 Characterization of cDNA for precursor of human luteinizing hormone releasing hormone

Seeburg, PH, Adelman, JP

Nature 1984
9419371 Second gene for gonadotropin-releasing hormone in humans

White, RB, Eisen, JA, Kasten, TL, Fernald, RD

Proc Natl Acad Sci U S A 1998
11707068 The genes encoding the type II gonadotropin-releasing hormone receptor and the ribonucleoprotein RBM8A in humans overlap in two genomic loci

Faurholm, B, Millar, RP, Katz, AA

Genomics 2001
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Orthologous Events
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