Reactome | GNRHR binds GNRH1,2

GNRHR binds GNRH1,2

Stable Identifier

R-HSA-391372

Type

Reaction [binding]

Species

Homo sapiens

Compartment

extracellular region, plasma membrane

Synonyms

Gonadotropin-releasing hormone receptor 1 can bind GNRH ligands

ReviewStatus

5/5

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Luteinizing hormone releasing hormone (LHRH, also termed gonadotropin releasing hormone GnRH), is a decapeptide involved in the control of human reproduction. There are two genes, LHRH I and II which encode two hormones (Seeburg & Adelman 1984, White et al. 1998). They are produced by hypothalamic neurones and mediates the release of luteinizing hormone (LH) and follicle stimulating hormone (FSH) from gonadotropic cells in the anterior pituitary. Their effects are mediated by binding to the gonadotropin-releasing hormone receptor 1 (GNRHR) (Kakar et al. 1992) which couples with the G protein alpha-q/11 subunit.

Literature References

PubMed ID	Title	Journal	Year
6090951	Characterization of cDNA for precursor of human luteinizing hormone releasing hormone Adelman, JP, Seeburg, PH	Nature	1984
1333190	Cloning, sequencing, and expression of human gonadotropin releasing hormone (GnRH) receptor Neill, JD, Kakar, SS, Sellers, JC, Musgrove, LC, Devor, DC	Biochem Biophys Res Commun	1992
9419371	Second gene for gonadotropin-releasing hormone in humans Eisen, JA, White, RB, Kasten, TL, Fernald, RD	Proc Natl Acad Sci U S A	1998