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GNRHR [plasma membrane]
Stable Identifier
R-HSA-391370
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
GnRH1 receptor, RecName: Full=Gonadotropin-releasing hormone receptor; Short=GnRH receptor; Short=GnRH-R;
GN Name=GNRHR; Synonyms=GRHR;
OS Homo sapiens, GNRHR_HUMAN
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (q) signalling events (Homo sapiens)
Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
GNRHR:GNRH1,2 [plasma membrane] (Homo sapiens)
GNRHR [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
GNRHR:GNRH1,2 [plasma membrane] (Homo sapiens)
GNRHR [plasma membrane] (Homo sapiens)
Liganded Gq/11-activating GPCRs act as GEFs for Gq/11 (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
GNRHR:GNRH1,2 [plasma membrane] (Homo sapiens)
GNRHR [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
GNRHR:GNRH1,2 [plasma membrane] (Homo sapiens)
GNRHR [plasma membrane] (Homo sapiens)
The Ligand:GPCR:Gq complex dissociates (Homo sapiens)
GPCRs that activate Gq/11 [plasma membrane] (Homo sapiens)
GNRHRs [plasma membrane] (Homo sapiens)
GNRHR [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
GNRHR:GNRH1,2 [plasma membrane] (Homo sapiens)
GNRHR [plasma membrane] (Homo sapiens)
GPCR ligand binding (Homo sapiens)
Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
Hormone ligand-binding receptors (Homo sapiens)
GNRHR binds GNRH1,2 (Homo sapiens)
GNRHR [plasma membrane] (Homo sapiens)
GNRHR:GNRH1,2 [plasma membrane] (Homo sapiens)
GNRHR [plasma membrane] (Homo sapiens)
GNRHR binds GNRHR peptide agonists (Homo sapiens)
GNRHR [plasma membrane] (Homo sapiens)
GNRHR:GNRHR peptide agonists [plasma membrane] (Homo sapiens)
GNRHR [plasma membrane] (Homo sapiens)
GNRHR binds GNRHR peptide antagonists (Homo sapiens)
GNRHR [plasma membrane] (Homo sapiens)
GNRHR:GNRHR peptide antagonists [plasma membrane] (Homo sapiens)
GNRHR [plasma membrane] (Homo sapiens)
GNRHR binds chemical antagonists (Homo sapiens)
GNRHR [plasma membrane] (Homo sapiens)
GNRHR:GNRHR chemical antagonists [plasma membrane] (Homo sapiens)
GNRHR [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P30968 GNRHR
Gene Names
GNRHR, GRHR
Chain
chain:1-328
Reference Genes
BioGPS Gene:2798 GNRHR
COSMIC (genes):GNRHR GNRHR
CTD Gene:2798 GNRHR
dbSNP Gene:2798 GNRHR
ENSEMBL:ENSG00000109163.7 GNRHR
HGNC:4421 GNRHR
KEGG Gene (Homo sapiens):2798 GNRHR
Monarch:2798 GNRHR
NCBI Gene:2798 GNRHR
OMIM:138850 GNRHR
UCSC:P30968 GNRHR
Reference Transcript
RefSeq:NM_001012763.1 GNRHR
RefSeq:NM_000406.2 GNRHR
Other Identifiers
0004810465
11740454_a_at
11740455_a_at
11740456_a_at
16976430
211522_PM_s_at
211522_s_at
211523_PM_at
211523_at
216341_PM_s_at
216341_s_at
2771822
2771823
2771824
2771825
2771826
2771827
2771830
2771831
2798
655_at
8100655
A_23_P155796
A_23_P155804
A_33_P3419006
GE557532
GO:0004930
GO:0004968
GO:0005886
GO:0005887
GO:0007165
GO:0007186
GO:0016020
GO:0016021
GO:0016500
GO:0023052
GO:0032274
GO:0042277
GO:0050886
GO:0060089
GO:0097211
HMNXSV003025469
Hs.73064.1.S1_3p_a_at
ILMN_1723999
ILMN_1755310
ILMN_2385918
L07949_at
PH_hs_0004199
TC04001251.hg
TC04002576.hg
g183421_3p_a_at
g292052_3p_at
Participates
as a component of
GNRHR:GNRHR chemical antagonists [plasma membrane] (Homo sapiens)
GNRHR:GNRHR peptide antagonists [plasma membrane] (Homo sapiens)
GNRHR:GNRHR peptide agonists [plasma membrane] (Homo sapiens)
GNRHR:GNRH1,2 [plasma membrane] (Homo sapiens)
as an input of
GNRHR binds chemical antagonists (Homo sapiens)
GNRHR binds GNRHR peptide antagonists (Homo sapiens)
GNRHR binds GNRHR peptide agonists (Homo sapiens)
GNRHR binds GNRH1,2 (Homo sapiens)
as a member of
GNRHRs [plasma membrane] (Homo sapiens)
Inferred To
Homologues of GNRHR [plasma membrane]
(Danio rerio)
GNRHR [plasma membrane]
(Bos taurus)
GNRHR [plasma membrane]
(Canis familiaris)
GNRHR [plasma membrane]
(Danio rerio)
GNRHR [plasma membrane]
(Sus scrofa)
gnrhr [plasma membrane]
(Xenopus tropicalis)
gnrr-1 [plasma membrane]
(Caenorhabditis elegans)
si:dkeyp-84g1.5 [plasma membrane]
(Danio rerio)
Gnrhr [plasma membrane]
(Mus musculus)
Gnrhr [plasma membrane]
(Rattus norvegicus)
AkhR [plasma membrane]
(Drosophila melanogaster)
Cross References
RefSeq
NP_001012781.1
,
NP_000397.1
Guide to Pharmacology - Targets
256
OpenTargets
ENSG00000109163
ZINC - Substances
GNRHR_HUMAN
ZINC target
P30968
PRO
P30968
PDB
7BR3
ZINC - Investigational
GNRHR_HUMAN
GeneCards
P30968
HPA
ENSG00000109163-GNRHR
Ensembl
ENSG00000109163
,
ENSP00000397561
,
ENST00000420975
,
ENSP00000226413
,
ENST00000226413
Pharos - Targets
P30968
Orphanet
16154
ZINC - Predictions - Purchasable
GNRHR_HUMAN
HMDB Protein
HMDBP02806
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